{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,31]],"date-time":"2025-08-31T10:20:36Z","timestamp":1756635636017,"version":"3.41.0"},"reference-count":12,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2025,5,3]],"date-time":"2025-05-03T00:00:00Z","timestamp":1746230400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diagnostic Cytopathology"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Human Herpesvirus 6 (HHV\u20106) is a ubiquitous virus that remains latent after primary infection but can reactivate in immunocompromised patients, leading to severe complications. Early detection of HHV\u20106 in respiratory samples is critical for timely intervention. We describe a 61\u2010year\u2010old immunocompromised woman who presented with pneumonitis and encephalopathy. Initial testing confirmed COVID\u201019, and worsening respiratory symptoms prompted bronchoalveolar lavage (BAL). Cytologic analysis of the BAL revealed epithelial cells with viral cytopathic effects, including multinucleation, chromatin margination, and nuclear inclusions. Plasma polymerase chain reaction (PCR) detected a high HHV\u20106 viral load, confirming HHV\u20106 pneumonitis and encephalitis. Despite antiviral treatment with Foscarnet and Ganciclovir, the patient's condition deteriorated, ultimately leading to her passing. This case highlights the importance of recognizing differential diagnoses of cytopathic effects in BAL specimens. Pathologists are crucial in identifying viral, infectious, or inflammatory conditions in BAL fluid, aiding in prompt diagnosis and management to improve patient care and prevent severe outcomes.<\/jats:p>","DOI":"10.1002\/dc.25481","type":"journal-article","created":{"date-parts":[[2025,5,3]],"date-time":"2025-05-03T09:39:39Z","timestamp":1746265179000},"page":"357-360","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Identifying <scp>HHV<\/scp>\u20106 Induced Cytopathic Effects in Bronchoalveolar Lavage Fluid Preparations to Enhance Care in Immunocompromised Patients"],"prefix":"10.1002","volume":"53","author":[{"given":"Komal","family":"Ijaz","sequence":"first","affiliation":[{"name":"Section of Cytopathology, Department of Anatomic Pathology, Division of Pathology and Laboratory Medicine The University of Texas MD Anderson Cancer Center  Houston Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4817-458X","authenticated-orcid":false,"given":"Gloria Hopkins","family":"Sura","sequence":"additional","affiliation":[{"name":"Section of Cytopathology, Department of Anatomic Pathology, Division of Pathology and Laboratory Medicine The University of Texas MD Anderson Cancer Center  Houston Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,5,3]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1086\/322691"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/v9070194"},{"volume-title":"Herpes Virus Type 6","year":"2025","author":"King O.","key":"e_1_2_8_4_1"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12985-017-0917-z"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1017\/CBO9780511545313.047"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1177\/09636897221119734"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1128\/9781555815974.ch4"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.3390\/v16040498"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2012.05.012"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2018.04.021"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/bmt.2017.175"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/ctr.13518"}],"container-title":["Diagnostic Cytopathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/dc.25481","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,4]],"date-time":"2025-06-04T04:16:56Z","timestamp":1749010616000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/dc.25481"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,3]]},"references-count":12,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2025,7]]}},"alternative-id":["10.1002\/dc.25481"],"URL":"https:\/\/doi.org\/10.1002\/dc.25481","archive":["Portico"],"relation":{},"ISSN":["8755-1039","1097-0339"],"issn-type":[{"type":"print","value":"8755-1039"},{"type":"electronic","value":"1097-0339"}],"subject":[],"published":{"date-parts":[[2025,5,3]]},"assertion":[{"value":"2025-03-04","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-04-26","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-05-03","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}