{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T18:09:59Z","timestamp":1780337399241,"version":"3.54.1"},"reference-count":20,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2025,5,31]],"date-time":"2025-05-31T00:00:00Z","timestamp":1748649600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diagnostic Cytopathology"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>The present study analyzed typical ultrasound manifestations and fine\u2010needle aspiration thyroglobulin (FNA\u2010Tg) levels to investigate their association with cervical lymph node metastasis in patients with papillary thyroid carcinoma (PTC).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The data of 139 PTC patients with ultrasonically suspected cervical lymph node metastasis treated in our hospital from December 2022 to November 2023 were retrospectively analyzed. All included patients underwent ultrasound examination of cervical lymph nodes, fine needle aspiration cytology (FNA\u2010C) examination, and ultrasound\u2010guided lymph node aspiration eluent thyroglobulin (FNA\u2010Tg). Typical ultrasound signs for diagnosing cervical lymph node metastasis (US\u2010M) and ultrasound\u2010guided FNA\u2010Tg for diagnosing cervical lymph node metastasis were compared and analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Results indicate that 71 patients were diagnosed with cervical lymph node metastasis through surgery and subsequently included in the metastatic group; the remaining 68 patients were included in the nonmetastatic group. The FNA\u2010Tg value in the metastatic group was higher than that in the nonmetastatic group; the difference was significant (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). The AUC values for diagnosing cervical lymph node metastasis in PTC patients using US\u2010M, FNA\u2010Tg, and US\u2010M+FNA\u2010Tg were 0.854, 0.927, and 0.952. When the cut\u2010off value of FNA\u2010Tg was 229.1\u2009ng\/mL, the sensitivity and specificity for diagnosing cervical lymph node metastasis in PTC patients were 84.5% and 89.5%.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Ultrasound\u2010guided FNA\u2010Tg level is closely related to cervical lymph node metastasis in patients with PTC. The combination of ultrasound examination and FNA\u2010Tg testing significantly enhances the accuracy of predicting lateral cervical lymph node metastasis in patients with PTC.<\/jats:p><\/jats:sec>","DOI":"10.1002\/dc.25489","type":"journal-article","created":{"date-parts":[[2025,5,31]],"date-time":"2025-05-31T14:18:57Z","timestamp":1748701137000},"page":"421-426","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Ultrasound Combined With <scp>FNA<\/scp>\u2010Tg Predicts the Lateral Cervical Lymph Node Metastasis in Papillary Thyroid Carcinoma"],"prefix":"10.1002","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4191-7400","authenticated-orcid":false,"given":"Yan","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Radiology University Kebangsaan Malaysia  Cheras Kuala Lumpur Malaysia"},{"name":"Department of Ultrasound Affiliated Hospital of Panzhihua University  Panzhihua China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Xiang","sequence":"additional","affiliation":[{"name":"Department of Ultrasound Affiliated Hospital of Panzhihua University  Panzhihua China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Thyroid Gland Breast Surgery Affiliated Hospital of Panzhihua University  Panzhihua China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noorazrul Azmie","family":"Yahya","sequence":"additional","affiliation":[{"name":"Diagnostic Imaging &amp; Radiotherapy Program, School of Diagnostic &amp; Applied Health Sciences, Faculty of Health Sciences National University of Malaysia  Kuala Lumpur Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing\u2010kun","family":"Yin","sequence":"additional","affiliation":[{"name":"Department of Ultrasound Affiliated Hospital of Panzhihua University  Panzhihua China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Ultrasound Affiliated Hospital of Panzhihua University  Panzhihua China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hamzaini Bin Abdul","family":"Hamid","sequence":"additional","affiliation":[{"name":"Department of Radiology University Kebangsaan Malaysia  Cheras Kuala Lumpur Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia\u2010ning","family":"Chai","sequence":"additional","affiliation":[{"name":"Department of Radiology University Kebangsaan Malaysia  Cheras Kuala Lumpur Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanani Abdul","family":"Manan","sequence":"additional","affiliation":[{"name":"Department of Radiology University Kebangsaan Malaysia  Cheras Kuala Lumpur Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,5,31]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejrad.2012.01.015"},{"issue":"6","key":"e_1_2_10_3_1","first-page":"1401","article-title":"Detection of Thyroglobulin in Fine Needle Aspirates of Nonthyroidal Neck Masses: A Clue to the Diagnosis of Metastatic Differentiated Thyroid Cancer","volume":"74","author":"Pacini F.","year":"1992","journal-title":"Journal of Clinical Endocrinology and 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Practice"},{"issue":"7","key":"e_1_2_10_13_1","first-page":"743","article-title":"Diagnostic Value of Chinese Thyroid Imaging Reporting and Data System in Thyroid Nodules With Different Sizes (in Chinese)","volume":"20","author":"Li W.","year":"2023","journal-title":"Chinese Journal of Medical Ultrasound (Electronic Edition)"},{"issue":"12","key":"e_1_2_10_14_1","first-page":"1060","article-title":"Values of Contrast\u2010Enhanced Ultrasound and Thyroglobulin Measurement in Fine\u2010Needle Aspiration for Detecting Lateral Cervical Lymph Node Metastasis of Papillary Thyroid Carcinoma","volume":"29","author":"Liu N.","year":"2020","journal-title":"Chinese Journal of Ultrasonography"},{"key":"e_1_2_10_15_1","volume-title":"The Influence of Thyroid Tissue Status on the Fna\u2010Tg Diagnostic Cutoff Value of Cervical Metastatic Lymph Nodes in Papillary Thyroid Carcinoma (in Chinese)","author":"Zhai L.","year":"2021"},{"key":"e_1_2_10_16_1","volume-title":"Clinical Characteristics Analysis and Ultrasound Diagnostic Evaluation of Cervical Lymph Node Metastasis in Papillary Thyroid Carcinoma (in Chinese)","author":"Geng Y.","year":"2021"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1177\/15330338221127605"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-15-0344"},{"issue":"4","key":"e_1_2_10_19_1","first-page":"455","article-title":"Ultrasound\u2010Related Risk Factors for Cervical Lymph Node Metastasis of Papillary Thyroid Microcarcinoma With Extracapsular Invasion","volume":"20","author":"Li S.","year":"2023","journal-title":"Chinese Journal of Medical Ultrasound (Electronic Edition)"},{"issue":"3","key":"e_1_2_10_20_1","first-page":"251","article-title":"Application of Contrast\u2010Enhanced Ultrasound Combined With Fine Needle Aspiration Biopsy and Thyroglobulin in Eluate in the Diagnosis of Lateral Cervical Lymph Node Metastasis in Papillary Thyroid Carcinoma (in Chinese)","volume":"39","author":"Lu J.","year":"2023","journal-title":"Chinese Journal of Ultrasound in Medicine"},{"issue":"4","key":"e_1_2_10_21_1","first-page":"313","article-title":"Application of Thyroglobulin Measurement in Fine\u2010Needle Aspiration for Detecting Lymph Node Metastasis in Papillary Thyroid Carcinoma (in Chinese)","volume":"28","author":"Ji L.","year":"2019","journal-title":"Chinese Journal of Ultrasonography"}],"container-title":["Diagnostic 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