{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,15]],"date-time":"2025-08-15T00:22:46Z","timestamp":1755217366696,"version":"3.43.0"},"reference-count":9,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2025,6,9]],"date-time":"2025-06-09T00:00:00Z","timestamp":1749427200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diagnostic Cytopathology"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>While the Paris system for reporting urinary cytology states that cells with well\u2010recognized and typical changes of polyoma virus (PV) infection should not lead to a diagnosis of \u2018atypia, the prognostic significance of PV\u2010like features is unknown.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Included were 284 urine cytology cases with PV or PV\u2010like changes. Four cell types were identified. Cell A was typical of PV infection, cell B had a spider\u2010web chromatin pattern, and cells C and D were degenerated cells with clumpy chromatin or homogeneous severely hyperchromatic nuclei, respectively. Events were correlated with a subsequent histological diagnosis of high\u2010grade urothelial carcinoma (HGUC).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>47% of cases had more than one cell type. The most common cell was D (64%) and the least common was A (27%). The most common cell to be present in isolation was D (<jats:italic>n<\/jats:italic>\u2009=\u2009109, 60%). 92% of cases with cell A had other cell types. Overall, the presence of cell A was associated with a benign follow\u2010up (1.2% association with HGUC). There was a gradual increase in the association with a HGUC diagnosis in cases with cells B (PPV\u2009=\u20098%), C (PPV\u2009=\u200915.5%), and D (PPV\u2009=\u200944%). The presence of only cells B, C, or D was predictive of HGUC in 22.4%, 33.3%, and 61.5%, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Cases with cell type A can be confidently diagnosed as \u2018negative for HGUC\u2019, even in the presence of associated cells with PV\u2010like changes. Cases with cells displaying PV\u2010like features (cell type B, C, or D) in the absence of type A features may represent degenerated HGUC cells.<\/jats:p><\/jats:sec>","DOI":"10.1002\/dc.25494","type":"journal-article","created":{"date-parts":[[2025,6,9]],"date-time":"2025-06-09T06:23:54Z","timestamp":1749450234000},"page":"447-453","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Spectrum of Polyoma Virus and Polyoma Virus\u2010Like Changes in Urine Cytology: When Should an Atypical Diagnosis Be Considered"],"prefix":"10.1002","volume":"53","author":[{"given":"Yaogong","family":"Li","sequence":"first","affiliation":[{"name":"University Hospital of Northern British Columbia  Prince George British Columbia Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yonca","family":"Kanber","sequence":"additional","affiliation":[{"name":"Department of Pathology McGill University and McGill University Health Center  Montreal Quebec Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Derin","family":"Caglar","sequence":"additional","affiliation":[{"name":"Department of Pathology McGill University and McGill University Health Center  Montreal Quebec Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wassim","family":"Kassouf","sequence":"additional","affiliation":[{"name":"Department of Surgery (Urology) McGill University Health Center  Montreal Quebec Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manon","family":"Auger","sequence":"additional","affiliation":[{"name":"Department of Pathology McGill University and McGill University Health Center  Montreal Quebec Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fadi","family":"Brimo","sequence":"additional","affiliation":[{"name":"Department of Pathology McGill University and McGill University Health Center  Montreal Quebec Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,6,9]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/medsci8010015"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2012.09.078"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncy.21700"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-22864-8"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-030-88686-8"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncy.21705"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jasc.2019.10.003"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6604711"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.5414\/CN108410"}],"container-title":["Diagnostic Cytopathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/dc.25494","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,5]],"date-time":"2025-08-05T12:39:48Z","timestamp":1754397588000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/dc.25494"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,9]]},"references-count":9,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2025,9]]}},"alternative-id":["10.1002\/dc.25494"],"URL":"https:\/\/doi.org\/10.1002\/dc.25494","archive":["Portico"],"relation":{},"ISSN":["8755-1039","1097-0339"],"issn-type":[{"type":"print","value":"8755-1039"},{"type":"electronic","value":"1097-0339"}],"subject":[],"published":{"date-parts":[[2025,6,9]]},"assertion":[{"value":"2024-12-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-05-28","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-06-09","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}