{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T18:51:53Z","timestamp":1788634313051,"version":"build-2803163510"},"reference-count":16,"publisher":"Wiley","license":[{"start":{"date-parts":[[2025,7,4]],"date-time":"2025-07-04T00:00:00Z","timestamp":1751587200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diagnostic Cytopathology"],"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Salivary duct carcinoma is a rare, high\u2010grade malignancy of the salivary glands, most commonly arising in the parotid. This review highlights recent advancements in the cytologic, immunophenotypic, and molecular characterization of salivary duct carcinoma, emphasizing the central role of biomarkers such as androgen receptor (AR) overexpression and <jats:italic>ERBB2<\/jats:italic> (HER2) amplification in diagnosis, prognosis, and therapeutic decision\u2010making. These principles are illustrated through the case of a 55\u2010year\u2010old male with AR\u2010positive, HER2\u2010amplified salivary duct carcinoma of the right parotid gland with nodal and osseous metastases. Diagnosis was established via fine\u2010needle aspiration (FNA) cytology, immunocytochemistry, and molecular profiling. The patient underwent androgen deprivation therapy followed by treatment with a HER2 targeted antibody\u2010drug conjugate, achieving disease stability. This case exemplifies how molecular diagnostics inform personalized treatment strategies in salivary duct carcinoma and underscores the need for standardized testing protocols and greater awareness of precision oncology approaches in salivary gland malignancies.<\/jats:p>","DOI":"10.1002\/dc.25501","type":"journal-article","created":{"date-parts":[[2025,7,4]],"date-time":"2025-07-04T11:40:54Z","timestamp":1751629254000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Targetable Molecular Profiles in Salivary Duct Carcinoma: A Review and Case Study of Molecular Diagnostic and Therapeutic Implications"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4817-458X","authenticated-orcid":false,"given":"Gloria Hopkins","family":"Sura","sequence":"first","affiliation":[{"name":"Sections of Cytopathology and Molecular Diagnostic Laboratory, Department of Anatomic Pathology, Division of Pathology and Laboratory Medicine The University of Texas MD Anderson Cancer Center  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,7,4]]},"reference":[{"issue":"4","key":"e_1_2_6_2_1","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1007\/s12105-022-01459-0","article-title":"Distribution and Frequency of Salivary Gland Tumours: An International Multicenter Study","volume":"16","author":"Alsanie I.","year":"2022","journal-title":"Head and Neck Pathology"},{"issue":"1","key":"e_1_2_6_3_1","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1007\/s12105-022-01420-1","article-title":"Update From the 5th Edition of the World Health Organization Classification of Head and Neck Tumors: Salivary Glands","volume":"16","author":"Skalova A.","year":"2022","journal-title":"Head and Neck Pathology"},{"key":"e_1_2_6_4_1","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1159\/000442120","article-title":"Frequency and Histopathology by Site, Major Pathologies, Symptoms and Signs of Salivary Gland Neoplasms","volume":"78","author":"Bradley P. 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