{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T07:05:49Z","timestamp":1762067149907},"reference-count":23,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2006,7,12]],"date-time":"2006-07-12T00:00:00Z","timestamp":1152662400000},"content-version":"vor","delay-in-days":6889,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostic Cytopathology"],"published-print":{"date-parts":[[1987,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The cytologic diagnosis of cervical condyloma is based on criteria developed over the last 10 years. It has now become possible to document the presence of human papilloma virus (HPV) DNA directly in cervical swabs by the highly sensitive technique of DNA filter hybridization in situ. The purpose of this article is to evaluate critically the empirically established cytologic criteria of condyloma by comparing them with HPV\u2010DNA hybridization studies in the same material. The results of this study indicate that \u2018classic\u2019 koilocytosis and dyskeratocytosis are not highly sensitive criteria for the presence of HPV infection, identifying only 15% of the HPV\u2010DNA\u2010positive cases correctly. In an attempt to improve the sensitivity of the cytologic diagnosis of HPV infections, a panel of nine \u2018nonclassic\u2019 criteria was evaluated. The five most valuable signs were \u2018mild koilocytosis,\u2019 mild dyskeratocytosis, hyperchromatic nuclei, bi\u2010 and multinucleation, and cleared cytoplasm. Using these criteria in combination, statistically discriminant analysis could correctly identify 84% of the HPV\u2010positive group.<\/jats:p>","DOI":"10.1002\/dc.2840030315","type":"journal-article","created":{"date-parts":[[2007,2,22]],"date-time":"2007-02-22T01:41:07Z","timestamp":1172108467000},"page":"250-255","source":"Crossref","is-referenced-by-count":68,"title":["Sensitivity of the cytologic diagnosis of cervical condyloma in comparison with HPV\u2010DNA hybridization studies"],"prefix":"10.1002","volume":"3","author":[{"given":"Achim","family":"Schneider","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriele","family":"Meinhardt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ethel\u2010Michele","family":"De\u2010Villiers","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lutz","family":"Gissmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,12]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1984.tb01944.x"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.80.12.3812"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.79.14.4437"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/0090-8258(81)90066-4"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910350405"},{"key":"e_1_2_1_7_2","first-page":"235","article-title":"An international agreement on histological terminology for lesions of the uterine cervix","volume":"6","author":"Wied G","year":"1962","journal-title":"Acta Cytol"},{"key":"e_1_2_1_8_2","first-page":"767","article-title":"Prognostic evaluation of different human papillomavirus types in early cervical neoplasia\u2013a cytologic\u2010virologic correlation study","volume":"64","author":"Wagner D","year":"1984","journal-title":"Obstet Gynecol"},{"key":"e_1_2_1_9_2","first-page":"1043","volume-title":"Origins of human cancer","author":"Orth G","year":"1977"},{"key":"e_1_2_1_10_2","first-page":"43","volume-title":"Clinics in dermatology","author":"Croissant O","year":"1985"},{"key":"e_1_2_1_11_2","first-page":"383","article-title":"Origin of the koilocyte in condylomata of the human cervix","volume":"25","author":"Casas\u2010Cordero M","year":"1981","journal-title":"Acta Cytol"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1097\/00004347-198302000-00007"},{"key":"e_1_2_1_13_2","first-page":"53","article-title":"Electron microscopic detection of papilloma virus particles in selected koilocytotic cells in a routine cervical smear","volume":"1","author":"Hills E","year":"1979","journal-title":"Acta Cytol"},{"key":"e_1_2_1_14_2","first-page":"82","article-title":"Human papillomavirus infection of the uterine cervix","volume":"24","author":"Morin SC","year":"1980","journal-title":"Acta Cytol"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(49)90804-2"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/76.3.255"},{"key":"e_1_2_1_17_2","first-page":"26","article-title":"Cytology of gynecologic condyloma acuminatum","volume":"221","author":"Purola E","year":"1977","journal-title":"Acta Cytol"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2008-1036449"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00446848"},{"key":"e_1_2_1_20_2","first-page":"554","article-title":"Prevalence of genital tract papillomaviruses in U.S. and West German women with cervical atypia as detected by filter in situ hybridization of exfoliated cells","volume":"69","author":"Schneider A","year":"1987","journal-title":"Obstet Gynecol"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12506324"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00403798"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1956.tb32134.x"},{"key":"e_1_2_1_24_2","first-page":"505","article-title":"Condylomatous lesions of the cervix and vagina. 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