{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T11:22:26Z","timestamp":1790335346394,"version":"4.1.0"},"reference-count":14,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2006,7,12]],"date-time":"2006-07-12T00:00:00Z","timestamp":1152662400000},"content-version":"vor","delay-in-days":6707,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostic Cytopathology"],"published-print":{"date-parts":[[1988,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The cytologic features of fine\u2010needle aspirates (FNA) of two hepatoblastomas (HBs) and a liver\u2010cell carcinoma (LCC) occurring in three children, ages 1, 3, and 14 yr, are presented. Electron microscopic features of one of the HBs and the LCC are also included. The HBs displayed single or small aggregates or larger clusters of cells with a high nuclear\u2010cytoplasmic ratio and usually round, hyperchromatic nuclei with single, and occasionally double, prominent nucleoli. In addition, one patient had extramedullary hematopoiesis; both had osteoid\u2010like material. These findings were very helpful in differentiating the HB cases from the LCC case, which had features similar to those of adult hepatocytes, including the presence of abundant, finely granular cytoplasm. Ultrastructural studies showed an absence of differentiation into adult hepatocytes in the HB, with scant organelles, rare bile canaliculi, lakes of glycogen, and rare lysosomal bodies. In contrast, the LCC showed features similar to adult hepatocytes, such as abundant cytoplasmic organelles, lysosomes, and bile canaliculi. In addition, intranuclear pseudoinclusions caused by cytoplasmic invagination were present in the LCC but not in the HB. Fine\u2010needle aspiration of hepatic masses in children is a useful technique for rendering a diagnosis, especially in unresectable tumors. Ultrastructural studies on FNA material may be important in differentiating hepatoblastoma from hepatocellular carcinoma.<\/jats:p>","DOI":"10.1002\/dc.2840040219","type":"journal-article","created":{"date-parts":[[2007,2,22]],"date-time":"2007-02-22T01:38:21Z","timestamp":1172108301000},"page":"162-168","source":"Crossref","is-referenced-by-count":30,"title":["Fine\u2010needle aspiration cytology of pediatric patients with primary hepatic tumors: A comparative study of two hepatoblastomas and a liver\u2010cell carcinoma"],"prefix":"10.1002","volume":"4","author":[{"given":"Roupen","family":"Dekmezian","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nour","family":"Sneige","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven","family":"Popok","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nelson G.","family":"Ord\u00f3\u00f1ez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,7,12]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/path.1711030202"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(1967)20:3<396::AID-CNCR2820200308>3.0.CO;2-O"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0046-8177(80)80108-0"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197003)25:3<551::AID-CNCR2820250309>3.0.CO;2-5"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.3109\/01913128309141840"},{"key":"e_1_2_1_7_2","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1093\/ajcp\/60.4.512","article-title":"Primary hepatic tumors in infancy and childhood","volume":"60","author":"Pollice L","year":"1970","journal-title":"Am J Clin Pathol"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(196901)23:1<191::AID-CNCR2820230125>3.0.CO;2-6"},{"issue":"5","key":"e_1_2_1_9_2","first-page":"1087","article-title":"Primary carcinoma of the liver in childhood: an epidemiologic study","volume":"40","author":"Fraumeni FJ","year":"1968","journal-title":"JNCI"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-3468(71)90467-2"},{"issue":"4","key":"e_1_2_1_11_2","first-page":"439","article-title":"Fine needle aspiration cytology in a case of hepatoblastoma","volume":"30","author":"Bhatia A","year":"1986","journal-title":"Acta Cytol"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1177\/29.4.6166661"},{"issue":"6","key":"e_1_2_1_13_2","first-page":"1275","article-title":"Primary carcinoma of the liver in infancy and childhood: report of 21 cases, with resection in 6 cases","volume":"60","author":"Lin TY","year":"1966","journal-title":"Surgery"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197912)44:6<2184::AID-CNCR2820440631>3.0.CO;2-U"},{"key":"e_1_2_1_15_2","first-page":"259","article-title":"Hepatoblastoma and hepatoma in infancy and childhood. Light and electron microscopic studies","volume":"87","author":"Ito J","year":"1969","journal-title":"Arch Pathol"}],"container-title":["Diagnostic Cytopathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fdc.2840040219","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/dc.2840040219","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,21]],"date-time":"2023-10-21T09:23:24Z","timestamp":1697880204000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/dc.2840040219"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1988,3]]},"references-count":14,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1988,3]]}},"alternative-id":["10.1002\/dc.2840040219"],"URL":"https:\/\/doi.org\/10.1002\/dc.2840040219","archive":["Portico"],"relation":{},"ISSN":["8755-1039","1097-0339"],"issn-type":[{"value":"8755-1039","type":"print"},{"value":"1097-0339","type":"electronic"}],"subject":[],"published":{"date-parts":[[1988,3]]}}}