{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,22]],"date-time":"2023-10-22T21:44:38Z","timestamp":1698011078875},"reference-count":7,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2006,7,12]],"date-time":"2006-07-12T00:00:00Z","timestamp":1152662400000},"content-version":"vor","delay-in-days":6585,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostic Cytopathology"],"published-print":{"date-parts":[[1988,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The distinction between repair atypia and carcinoma in esophageal brushings is often difficult. To establish criteria for making this distinction, the cytologic smears from 121 consecutive esophageal brushings and the companion biopsies were reviewed. The most reliable criteria for malignancy included sharply angulated nuclear rims, a high nuclear\/cytoplasmic ratio, and coarsely granular chromatin. Nuclei bearing these features were not numerous and had to be carefully sought. Nuclear pleomorphism was a more consistent feature, but it showed considerable overlap with epithelial repair. Cytologic features of multiple nucleoli, macronucleoli, and loss of polarity were common to both repair and carcinoma. Adherence to the criteria established in this study permits the distinction between repair atypia and carcinoma in almost all cases; however, there are lesions of the esophagus with such overlap between the features of repair and carcinoma that it may not be possible to reach a definitive diagnosis. Specific examples, with illustrations, are discussed as diagnostic guides.<\/jats:p>","DOI":"10.1002\/dc.2840040308","type":"journal-article","created":{"date-parts":[[2007,2,22]],"date-time":"2007-02-22T01:38:14Z","timestamp":1172108294000},"page":"217-223","source":"Crossref","is-referenced-by-count":6,"title":["Epithelial repair versus carcinoma in esophageal brush cytology"],"prefix":"10.1002","volume":"4","author":[{"given":"Lola","family":"Hoover","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jules J.","family":"Berman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,12]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"133","article-title":"The cytologic diagnosis of tissue repair in the female genital tract","volume":"15","author":"Bibbo M","year":"1971","journal-title":"Acta Cytol"},{"key":"e_1_2_1_3_2","first-page":"371","article-title":"Epithelial repair and regeneration in the uterine cervix. I. An analysis of the cells","volume":"21","author":"Geirsson G","year":"1977","journal-title":"Acta Cytol"},{"key":"e_1_2_1_4_2","first-page":"439","article-title":"Analytical study of repair cells","volume":"26","author":"Sugimori H","year":"1982","journal-title":"Acta Cytol"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/dc.2840010204"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0074-7696(08)61833-1"},{"key":"e_1_2_1_7_2","first-page":"313","article-title":"Endoscopic brush border cytology and biopsy in the diagnosis of cancer of the upper gastrointestinal tract","volume":"24","author":"Qizilbash AH","year":"1980","journal-title":"Acta Cytol"},{"key":"e_1_2_1_8_2","first-page":"219","article-title":"Brushing cytology of the esophagus and stomach under direct vision by fiberscopes","volume":"14","author":"Kobayashi S","year":"1970","journal-title":"Acta Cytol"}],"container-title":["Diagnostic Cytopathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fdc.2840040308","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/dc.2840040308","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,22]],"date-time":"2023-10-22T21:00:59Z","timestamp":1698008459000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/dc.2840040308"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1988,7]]},"references-count":7,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1988,7]]}},"alternative-id":["10.1002\/dc.2840040308"],"URL":"https:\/\/doi.org\/10.1002\/dc.2840040308","archive":["Portico"],"relation":{},"ISSN":["8755-1039","1097-0339"],"issn-type":[{"value":"8755-1039","type":"print"},{"value":"1097-0339","type":"electronic"}],"subject":[],"published":{"date-parts":[[1988,7]]}}}