{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T03:36:50Z","timestamp":1784259410786,"version":"3.55.0"},"reference-count":26,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2006,7,12]],"date-time":"2006-07-12T00:00:00Z","timestamp":1152662400000},"content-version":"vor","delay-in-days":6401,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostic Cytopathology"],"published-print":{"date-parts":[[1989,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Lipoidpneumonia (LP) is an uncommon entity with the characteristic radiographic features and histologic findings of alveoli filled with vacuolated, lipid\u2010laden histiocytes. We questioned whether bronchoalveolar lavage (BAL) could be useful in the confirmation of LP. We examined lipid stains (oil\u2010red O) in BAL specimens from 18 cases, representing a variety of pulmonary disease states, and compared them with an index case of confirmed LP. The index case of LP had a history of chronic intranasal use of mentholated petrolatum with subsequent x\u2010ray findings of progressive air bronchograms. Positive histochemical confirmation (oil\u2010red O) performed on frozen sections of transbronchial lung biopsy was obtained. Eleven of the non\u2010LP cases had no intracellular staining of BAL macrophages with oil\u2010red O stain, whereas the index case of LP exhibited markedly positive intracytoplasmic staining of macrophages for lipid. The remaining seven cases showed minimal to mild lipid staining with only one other case having moderate staining. This study demonstrates that BAL macrophages from patients with a variety of pulmonary states and without suspected LP do not demonstrate significant staining for intracellular lipids, in contrast with the expected strong positivity of LP. Lipid staining of BAL specimens, although not entirely specific may be a preferred method for confirming the diagnosis of LP. thereby avoiding more invasive procedures.<\/jats:p>","DOI":"10.1002\/dc.2840050103","type":"journal-article","created":{"date-parts":[[2007,2,22]],"date-time":"2007-02-22T01:38:09Z","timestamp":1172108289000},"page":"3-8","source":"Crossref","is-referenced-by-count":45,"title":["Bronchoalveolar lavage in the diagnosis of lipoid pneumonia"],"prefix":"10.1002","volume":"5","author":[{"given":"Jan F.","family":"Silverman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert C.","family":"Turner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. Lee","family":"West","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas A.","family":"Dillard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,7,12]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"383","volume-title":"Major problems in pathology","author":"Katzenstein AL","year":"1982"},{"key":"e_1_2_1_3_2","first-page":"74","volume-title":"Diagnostic respiratory cytopathology","author":"Johnston WW","year":"1979"},{"key":"e_1_2_1_4_2","first-page":"45","article-title":"Chemical analysis of the bronchoalveolar washing fluid in the diagnosis of liquid paraffin pneumonia","volume":"25","author":"Levade T","year":"1987","journal-title":"J Clin Chem Clin Biochem"},{"issue":"1","key":"e_1_2_1_5_2","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/S0272-5231(21)00463-9","article-title":"Clinical applications of bronchoalveolar lavage","volume":"8","author":"Turner\u2010Warwick M","year":"1987","journal-title":"Clin Chest Med"},{"issue":"1","key":"e_1_2_1_6_2","first-page":"250","article-title":"Bronchoalveolar lavage","volume":"135","author":"Reynolds HY","year":"1987","journal-title":"Am Rev Respir Dis"},{"issue":"5","key":"e_1_2_1_7_2","first-page":"293","article-title":"Bronchoalveolar lavage in the investigation of disorders of the lower respiratory tract","volume":"69","author":"Rossi GA","year":"1986","journal-title":"Eur J Respir Dis"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-102-1-93"},{"key":"e_1_2_1_9_2","first-page":"751","article-title":"Interstitial lung disease. 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