{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,24]],"date-time":"2025-09-24T10:32:22Z","timestamp":1758709942405},"reference-count":32,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2006,7,12]],"date-time":"2006-07-12T00:00:00Z","timestamp":1152662400000},"content-version":"vor","delay-in-days":6342,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostic Cytopathology"],"published-print":{"date-parts":[[1989,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>This study investigated whether the analysis of T cell subsets and of activation markers on T cells in pleural fluids can be helpful for diagnostic purposes in tuberculous pleurisy and other lymphocyte\u2010rich pleural effusions. Pleural effusion fluids were obtained from 18 patients with tuberculous pleurisy (TB), 21 with effusions following radiotherapy (RT) for a malignant disease, and 11 with congestive heart failure (CHF). Lymphocyte subsets were analyzed by a battery of monoclonal antibodies using an immunoperoxidase method. The majority of the lymphocytes were CD3\u2010positive T cells (TB, 86 \u00b1 7% of lymphocytes; RT, 81 \u00b1 8%; CHF, 84 \u00b1 12%). The ratios of CD4\u2010positive helper\u2010inducer to CD8\u2010positive suppressor\u2010cytotoxic T cells were higher than those reported for the peripheral blood but not significantly different between the study groups (TB, 3.3 \u00b1 1.9; RT, 2.8 \u00b1 1.1). The activation marker studies revealed that only a few pleural T cells were positive for CD38, CD25 (interleukin\u20102 receptor), HLA\u2010DR antigen, and OKT9 (transferrin receptor), the proportion of CD25\u2010positive T cells being higher in TB and in RT than in CHF and the proportion of HLA\u2010DR\u2010positive T cells being higher in TB than in CHF (P &lt; 0.05). Significant differences were not observed relative to the natural killer\u2010cytotoxic phenotypes staining positive for Leu\u20107 or for CD16. Thus, we concluded that phenotypic analysis of lymphocytes is of limited diagnostic usefulness to differentiate tuberculous from other nonmalignant effusions.<\/jats:p>","DOI":"10.1002\/dc.2840050206","type":"journal-article","created":{"date-parts":[[2007,2,22]],"date-time":"2007-02-22T01:50:53Z","timestamp":1172109053000},"page":"139-144","source":"Crossref","is-referenced-by-count":14,"title":["Tuberculous pleural effusions: Lymphocyte phenotypes in comparison with other lymphocyte\u2010rich effusions"],"prefix":"10.1002","volume":"5","author":[{"given":"Josune","family":"Guzman","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Klaus 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