{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:39:07Z","timestamp":1786977547735,"version":"build-2736575974"},"reference-count":22,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2006,8,18]],"date-time":"2006-08-18T00:00:00Z","timestamp":1155859200000},"content-version":"vor","delay-in-days":6073,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostic Cytopathology"],"published-print":{"date-parts":[[1990,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>We studied lymph node fine\u2010needle aspirations from 10 patients with primary Epstein\u2010Barr virus (EBV) infections (infectious mononucleosis). There were five males and five females, aged 15\u201054yr. The diagnoses were confirmed by blood morphology and heterophil antibody (HA) and EBV\u2010specific serologic studies. Nine patients were HA\u2010positive, nine were viral capsid antigen (VCA)\u2010IgM\u2010positive, and all 10 were VCA\u2010IgG\u2010positive and anti\u2010EBV nuclear antigen (EBNA)\u2010negative. Five patients were referred for fine\u2010needle aspiration biopsies for clinically suspected malignant lymphoma (ML). Four of these patients had been tested for HA prior to fine\u2010needle aspiration, with negative results in three cases. The heterophil\u2010positive patient was referred for fine\u2010needle aspiration due to very impressive unilateral cervical adenopathy. Cytologically, all cases showed atypia consisting of greater numbers of large immunoblastic lymphocytes than are usually seen in the reactive lymph node. Two cases were cytologically suspicious for malignant lymphoma but included a considerable background of polymorphic immunoblasts. We suggest that polymorphic immunoblastic proliferations in lymph node cytology are suggestive of infectious mononucleosis. Since several reactive and neoplastic processes mimic this pattern, cases not followed by both confirmatory serologic studies and resolution of adenopathy should be pursued by excisional lymph node biopsy.<\/jats:p>","DOI":"10.1002\/dc.2840060507","type":"journal-article","created":{"date-parts":[[2007,2,21]],"date-time":"2007-02-21T20:47:13Z","timestamp":1172090833000},"page":"323-329","source":"Crossref","is-referenced-by-count":26,"title":["Fine\u2010needle aspiration of lymph nodes in patients with acute infectious mononucleosis"],"prefix":"10.1002","volume":"6","author":[{"given":"Michael W.","family":"Stanley","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theresa A.","family":"Steeper","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles A.","family":"Horwitz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda G.","family":"Burton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John G.","family":"Strickler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stuart","family":"Borken","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,8,18]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-198307000-00005"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0046-8177(74)80005-5"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197105)27:5<1029::AID-CNCR2820270505>3.0.CO;2-W"},{"key":"e_1_2_1_5_2","first-page":"122","article-title":"Infectious mononucleosis","volume":"11","author":"Childs CC","year":"1987","journal-title":"The spectrum of morphologic changes simulating lymphoma in lymph nodes and tonsils. Am J Surg Pathol"},{"key":"e_1_2_1_6_2","first-page":"317","article-title":"Reactive immunoblastic proliferations","volume":"5","author":"Nathwani BN","year":"1988","journal-title":"Semin Diagn Pathol"},{"key":"e_1_2_1_7_2","first-page":"722","article-title":"Cytology and immunocytology of infectious mononucleosis in fine needle aspirates of lymph nodes","volume":"32","author":"Kardos TF","year":"1988","journal-title":"Acta Cytol"},{"key":"e_1_2_1_8_2","first-page":"680","article-title":"Infectious mononucleosis","volume":"109","author":"O'Brien A","year":"1985","journal-title":"Appendiceal lymphoid tissue involvement parallels characteristic lymph node changes. Arch Pathol Lab Med"},{"key":"e_1_2_1_9_2","first-page":"441","volume-title":"Diagnostic procedures for viral, rickettsial and chlamydial infections","author":"Henle W","year":"1979"},{"key":"e_1_2_1_10_2","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1128\/jcm.17.4.619-624.1983","article-title":"Limitations of available tests for diagnosis of infectious mononucleosis","volume":"17","author":"Fleisher GR","year":"1983","journal-title":"J Clin Microbiol"},{"key":"e_1_2_1_11_2","first-page":"807","article-title":"Persistent falsely positive rapid tests for infectious mononucleosis","volume":"72","author":"Horwitz CA","year":"1979","journal-title":"Report of five cases with 4\u20106 year follow\u2010up data. Am J Clin Pathol"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197003)25:3<626::AID-CNCR2820250318>3.0.CO;2-T"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197007)26:1<176::AID-CNCR2820260123>3.0.CO;2-I"},{"key":"e_1_2_1_14_2","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1093\/ajcp\/58.6.607","article-title":"\u201cReed\u2010Sternberg cells\u201d in infectious mononucleosis?","volume":"58","author":"Tindle BH","year":"1972","journal-title":"Am J Clin Pathol"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/85.3.283"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0046-8177(88)80148-5"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(77)90550-2"},{"key":"e_1_2_1_18_2","first-page":"631","article-title":"Horse agglutinins in infectious mononucleosis","volume":"21","author":"Lee CL","year":"1968","journal-title":"III. Criterion for differential diagnosis. J Clin Pathol"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0046-8177(74)80006-7"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/130.3.231"},{"key":"e_1_2_1_21_2","first-page":"954","article-title":"Application of a modified Diff\u2010Quik stain to fine needle aspiration smears: rapid staining with improved cytologic detail","volume":"31","author":"Henry MJ","year":"1987","journal-title":"Acta Cytol"},{"key":"e_1_2_1_22_2","first-page":"554","article-title":"Fine needle aspiration cytology of benign lymph node hyperplasia","volume":"29","author":"O'Dowd GJ","year":"1985","journal-title":"Diagnostic significance of lymphohistiocytic aggregates. Acta Cytol"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(88)92783-3"}],"container-title":["Diagnostic Cytopathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fdc.2840060507","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/dc.2840060507","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,22]],"date-time":"2023-10-22T18:27:27Z","timestamp":1697999247000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/dc.2840060507"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1990,1]]},"references-count":22,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1990,1]]}},"alternative-id":["10.1002\/dc.2840060507"],"URL":"https:\/\/doi.org\/10.1002\/dc.2840060507","archive":["Portico"],"relation":{},"ISSN":["8755-1039","1097-0339"],"issn-type":[{"value":"8755-1039","type":"print"},{"value":"1097-0339","type":"electronic"}],"subject":[],"published":{"date-parts":[[1990,1]]}}}