{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T15:00:20Z","timestamp":1770822020658,"version":"3.50.1"},"reference-count":36,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2006,7,12]],"date-time":"2006-07-12T00:00:00Z","timestamp":1152662400000},"content-version":"vor","delay-in-days":5612,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostic Cytopathology"],"published-print":{"date-parts":[[1991,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>After reviewing collection techniques and the cytology of normal and reactive hepatocytes, a systematic approach to the evaluation of fine\u2010needle aspiration biopsy smears of hepatic mass lesions is presented. One of the main problems facing the cytopathologist is the differentiation of cirrhosis from well\u2010differentiated hepatocel\u2010Mar carcinoma. Smears from patients with cirrhosis often contain clusters of bile duct epithelial cells and chronic inflammatory cells, while properly sampled hepatocellular carcinoma smears should contain no bile duct epithelial cells and few inflammatory cells. Key criteria which favor the diagnosis of hepatocellular carcinoma over cirrhosis are: increased nuclear to cytoplasmic ratio, trabecular pattern, and atypical naked hepatocytic nuclei. Key criteria which favor the diagnosis of primary hepatocellular carcinoma over metastatic disease include polygonal cells with centrally placed nuclei, cells separated by sinusoidal capillaries, and bile. This systematic approach to the evaluation of hepatic fine\u2010needle aspiration biopsies must be used with the realization that other uncommon mass lesions of the liver do exist vocal nodular hyperplasia, adenoma, hepatoblastoma, bile duct carcinoma, vascular tumors, mesenchymal tumors, and lymphomas).<\/jats:p>","DOI":"10.1002\/dc.2840070220","type":"journal-article","created":{"date-parts":[[2007,2,22]],"date-time":"2007-02-22T01:44:18Z","timestamp":1172108658000},"page":"204-210","source":"Crossref","is-referenced-by-count":41,"title":["An approach to fine\u2010needle aspiration biopsy diagnosis of hepatic masses"],"prefix":"10.1002","volume":"7","author":[{"given":"Kent","family":"Bottles","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael B.","family":"Cohen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,12]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.3109\/00365527109181138"},{"key":"e_1_2_1_3_2","first-page":"1","article-title":"Fine needle aspiration biopsy of the liver","volume":"520","author":"Lundquist A","year":"1971","journal-title":"Acta Med Scand"},{"key":"e_1_2_1_4_2","first-page":"25","volume-title":"Clinical aspiration cytology","author":"Salzman AJ","year":"1983"},{"key":"e_1_2_1_5_2","first-page":"1","volume-title":"Guides to clinical aspiration biopsy: liver and pancreas","author":"Neiman HL","year":"1988"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.154.1.2104689"},{"key":"e_1_2_1_7_2","first-page":"22","volume-title":"Aspiration biopsy: cytologic interpretation and histologic basis","author":"Rosenblatt R","year":"1984"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(86)90309-8"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/dc.2840010114"},{"key":"e_1_2_1_10_2","first-page":"1225","article-title":"Immunocytochemical evaluation of liver fine needle aspirations","volume":"113","author":"Bedrossian CWM","year":"1989","journal-title":"Arch Pathol Lab Med"},{"key":"e_1_2_1_11_2","first-page":"476","article-title":"Comparison of cytologic examination of smears and histologic examination of tissue cores obtained by fine needle aspiration biopsy of the liver","volume":"31","author":"Cochand\u2010Priollet B","year":"1987","journal-title":"Acta Cytol"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/jcu.1870110205"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-662-25530-8_26"},{"key":"e_1_2_1_14_2","volume-title":"Aspiration biopsy: cytologic interpretation and histologic basis","author":"Koss LG","year":"1984"},{"key":"e_1_2_1_15_2","first-page":"291","volume-title":"Practical cytopathology","author":"Chandrasoma P","year":"1990"},{"key":"e_1_2_1_16_2","volume-title":"Guides to clinical aspiration biopsy: liver and pancreas","author":"Frias\u2010Hidvegi D","year":"1988"},{"key":"e_1_2_1_17_2","volume-title":"Clinical aspiration cytology","author":"Linsk JA","year":"1983"},{"key":"e_1_2_1_18_2","volume-title":"Aspiration biopsy cytology. 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