{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T18:05:19Z","timestamp":1758823519272},"reference-count":28,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2006,7,12]],"date-time":"2006-07-12T00:00:00Z","timestamp":1152662400000},"content-version":"vor","delay-in-days":5551,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostic Cytopathology"],"published-print":{"date-parts":[[1991,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>An 8\u2010mo (August 1988 through April 1989) study was performed to evaluate the efficacy of the modified Ayre spatula\/Zelsmyr Cytobrush versus the modified Ayre spatula\/bulb aspirator in the collection of cells, both normal and abnormal, from the uterine cervix. The majority (78%) of the 192 patients, ranging in age from 18 to 82 yr, were referred to the gynecologic\/oncologic clinic for follow\u2010up of an atypical Papanicolaou smear or of a previously diagnosed and treated cervical, vulvar, or endometrial lesion. Of the 192 patients, 149 were premenopausal (15 of whom were pregnant), 12 were perimenopausal, and 31 were postmenopausal. Patients were randomized into one of two groups based on the collection of samples for their cervical smears: 1) modified Ayre spatula (exocervix) plus Zelsmyr Cytobrush (endocervix; 90 cases) and 2) modified Ayre spatula (exocervix) plus bulb aspirator (endocervix; 102 cases). Of the smears prepared with the spatula\/Cytobrush (90 cases), only 2 (2.2%) lacked endocervical cells. Within this group, the smears of 5 of 5 pregnantpatients (100%) and 13 of 13 postmenopausal patients (100%) contained endocervical cells. Cytologic abnormalities were present in 15 of these cases: koilocytosis in 4, cervical intraepithelial neoplasia (CIN)\u2010I in 5, CIN\u2010II in 4, and CIN\u2010III in 2. Five of the 15 cytologically positive cases had histologic verification; the cytologic findings were predictive of the histologic findings in all. Of the smears prepared using the spatula\/bulb aspirator (102 cases), 26 (25.5%) lacked endocervical cells. Within this group, the smears of only 4 of 10 pregnant patients (40%) and 14 of 18 postmenopausal patients (78%) contained endocervical cells. Cytologic abnormalities were diagnosed in 23 of these 102 cases: koilocytosis in 6, CIN\u2010I in 12, CIN\u2010II in 3, and CIN\u2010III in 2. Fourteen of the 23 cytologically positive cases had histologic verification; cytologic underestimation of the severity of the lesion occurred in 5 cases (4 in CIN\u2010III and I in CIN\u2010II lesions). The results of this study indicate that the modified Ayre spatula\/Zelsmyr Cytobrush technique is more effective than the modified Ayre spatula\/bulb aspirator technique in obtaining an adequate cervical cell sample containing endocervical cells, particularly in pregnant and postmenopausal patients, and in may aid in predicting the histologic severity of the cervical lesion.<\/jats:p>","DOI":"10.1002\/dc.2840070322","type":"journal-article","created":{"date-parts":[[2007,2,22]],"date-time":"2007-02-22T02:20:47Z","timestamp":1172110847000},"page":"318-322","source":"Crossref","is-referenced-by-count":6,"title":["Sampling accuracy of the modified ayre spatula\/zelsmyr cytobrush versus the modified ayre spatula\/bulb aspirator in the collection of cells from the uterine cervix"],"prefix":"10.1002","volume":"7","author":[{"given":"Suzanne M.","family":"Selvaggi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vinay","family":"Malviya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,12]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.2105\/AJPH.68.2.125"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.252.11.1423"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(77)90223-X"},{"key":"e_1_2_1_5_2","first-page":"10","volume-title":"Cancer Facts and Figures\u20131988","year":"1988"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(74)90013-1"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(196511)18:11<1474::AID-CNCR2820181117>3.0.CO;2-V"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(70)90425-4"},{"key":"e_1_2_1_9_2","first-page":"576","article-title":"The false negative smear II. The trapping effect of collecting instruments","volume":"49","author":"Rubio CA","year":"1977","journal-title":"Obstet Gynecol"},{"key":"e_1_2_1_10_2","first-page":"251","article-title":"The influence of sample takers on the cellular composition of cervical smears","volume":"30","author":"Vooijs GP","year":"1986","journal-title":"Acta Cytol"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1097\/00006254-196907001-00019"},{"key":"e_1_2_1_12_2","first-page":"792","article-title":"Standards of adequacy of cytologic examination of the female genital tract: Conclusions of study group on cytology","volume":"43","author":"Koss LG","year":"1974","journal-title":"Obstet Gynecol"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(87)80004-2"},{"key":"e_1_2_1_14_2","first-page":"913","article-title":"Letters to the Editor: Replies to questions on quality assurance measures in cytopathology","volume":"32","year":"1988","journal-title":"Acta 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BW","year":"1988","journal-title":"Acta Cytol"},{"key":"e_1_2_1_20_2","first-page":"264","article-title":"Consequences of the introduction of combined spatula and cytobrush sampling for cervical cytology: Improvements in smear quality and detection rates","volume":"30","author":"Boone ME","year":"1986","journal-title":"Acta Cytol"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1002\/dc.2840030317"},{"key":"e_1_2_1_22_2","first-page":"801","article-title":"Diagnostic accuracy of squamous cervical lesions studied in spatula\u2010cytobrush smears","volume":"32","author":"Alons\u2010van Kordelaar JJM","year":"1988","journal-title":"Acta Cytol"},{"key":"e_1_2_1_23_2","first-page":"843","article-title":"Analysis of five sampling methods for the preparation of cervical smears","volume":"33","author":"Boone ME","year":"1989","journal-title":"Acta 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