{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,23]],"date-time":"2023-10-23T13:10:37Z","timestamp":1698066637251},"reference-count":30,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2006,7,12]],"date-time":"2006-07-12T00:00:00Z","timestamp":1152662400000},"content-version":"vor","delay-in-days":5490,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostic Cytopathology"],"published-print":{"date-parts":[[1991,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Cytologic evaluation of cervical smears has been carried out in 3,374 women who used different modes of contraception (Lippes loop, copper T200, copper T220, copper devices containing higher copper content than the copper T200, Cu T380 Ag, levonorgestrel IUD, injections of noresthisterone oenanthate, and subdermal implants of levonorgestrel) under the Contraceptive Testing Programme of Indian Council of Medical Research for periods ranging from 6 months to 15 yr. While no case of severe dysplasia or malignancy was noticed with any type of contraceptive, 113 dysplastic smears (99 mild and 14 moderate) were encountered on follow\u2010up, giving an incidence of 3.3%, which was statistically insignificant compared with the pretreatment incidence of 1.4% (47 of 3,374). The highest incidence of dysplasia was seen with devices containing a high copper content (9.2%), followed by CuT200 (6.1%) and levonorgestrel implants (4.2%), and was lowest with Lippes loop (1.8%), injection of noresthisterone oenanthate (1.7%), and CuT380 Ag (1.5%), but statistics higher than the pretreatment incidence of 1.4% were seen only with CuT200 and devices containing high copper content. Retrogression of dysplasia was seen in 85 of the 94 posttreatment dysplasia cases and in all 47 pretreatment dysplasia cases, whereas in the remaining nine posttreatment cases of dysplasia the lesion persisted for 6\u201012 mo, necessitating discontinuation of contraception.<\/jats:p><jats:p>The accumulated follow\u2010up data indicate that the CuT380 Ag device is a promising IUD for the future in view of its low incidence of dysplasia determined during its use up to 5 yr. However, more prolonged follow\u2010up in larger numbers of subjects is required to confirm its innocuosness on long\u2010term retention.<\/jats:p>","DOI":"10.1002\/dc.2840070405","type":"journal-article","created":{"date-parts":[[2007,2,22]],"date-time":"2007-02-22T02:16:00Z","timestamp":1172110560000},"page":"346-352","source":"Crossref","is-referenced-by-count":4,"title":["Cervical carcinogenesis and contraception"],"prefix":"10.1002","volume":"7","author":[{"given":"Jata S.","family":"Misra","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amy D.","family":"Engineer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kalyani","family":"Das","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Prabha","family":"Tandon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,12]]},"reference":[{"key":"e_1_2_1_2_2","series-title":"WHO Monogr Ser","first-page":"3","volume-title":"Cytology of female genital tract","author":"W.H.O.","year":"1973"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.3181\/00379727-67-16195P"},{"key":"e_1_2_1_4_2","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/S0002-9378(16)34654-3","article-title":"Induction of subcutaneous tumors in rats by plastic loop and spirals","volume":"96","author":"Southarn EM","year":"1966","journal-title":"Am J Obstet Gynecol"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(67)90086-5"},{"key":"e_1_2_1_6_2","first-page":"1038","volume":"9","author":"Fujimori H","year":"1957","journal-title":"World Obstet Gynecol"},{"key":"e_1_2_1_7_2","first-page":"181","volume":"3","author":"Nakamura N","year":"1958","journal-title":"Japn J Fertil Steril"},{"key":"e_1_2_1_8_2","first-page":"8","article-title":"Clinical studies on intrauterine rings especially the present state of contraception in Japan and experiences with use of intrauterine rings","volume":"10","author":"Ishihama A","year":"1959","journal-title":"Med J"},{"key":"e_1_2_1_9_2","first-page":"315","article-title":"Intrauterine contraception: A long new approach","volume":"24","author":"Morguiles LC","year":"1964","journal-title":"Obstet Gynaecol"},{"key":"e_1_2_1_10_2","first-page":"1403","article-title":"Contraception by intrauterine devices","volume":"96","author":"Teitz C","year":"1966","journal-title":"Am J Obstet Gynecol"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(67)90081-6"},{"key":"e_1_2_1_12_2","first-page":"456","article-title":"Pilot study with Lippes loop in La Paz, Bolivia","volume":"23","author":"Tichauer RW","year":"1968","journal-title":"J Am Med Women Assoc"},{"key":"e_1_2_1_13_2","first-page":"393","article-title":"Human precarcinogenic cell manifestation associated with polyethylene contraceptive device","volume":"34","author":"Ayre JE","year":"1965","journal-title":"Ind Med Surg"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1097\/00007611-196709000-00020"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(15)33390-1"},{"key":"e_1_2_1_16_2","first-page":"35","article-title":"Cytological and histological studies after long insertions of intrauterine devices","volume":"14","author":"Ishihama A","year":"1970","journal-title":"Acta Cytol"},{"key":"e_1_2_1_17_2","first-page":"35","article-title":"Vaginal cytology with silicon polymer intrauterine devices","volume":"7","author":"Schwartz T","year":"1967","journal-title":"Cancer Cytol"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1080\/00224496709550548"},{"key":"e_1_2_1_19_2","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/S0002-9378(16)34389-7","article-title":"Contraception with Grafenberg ring","volume":"103","author":"Hill AM","year":"1969","journal-title":"Am J Obstet Gynecol"},{"key":"e_1_2_1_20_2","first-page":"58","article-title":"Cytology of intrauterine contraceptive devices","volume":"14","author":"Sagiroglu N","year":"1970","journal-title":"Acta Cytol"},{"key":"e_1_2_1_21_2","unstructured":"TatumHJ. In: Marchesi M ed.Schering postgraduate symposium. Genoa 1972."},{"key":"e_1_2_1_22_2","first-page":"165","article-title":"Studies on the mode of action of CuT device","volume":"71","author":"Hagenfeldt K","year":"1972","journal-title":"Acta Endocrinol (Suppl)"},{"key":"e_1_2_1_23_2","first-page":"1787","article-title":"Surveillance for carcinogenesis in women using Cu\u2010IUD for contraception","volume":"63","author":"Luthra UK","year":"1975","journal-title":"Indian J Med Res"},{"key":"e_1_2_1_24_2","first-page":"23","article-title":"Comparative cervical cytology in women using different types of copper IUDs","volume":"74","author":"Engineer AD","year":"1981","journal-title":"Indian J Med Res"},{"key":"e_1_2_1_25_2","first-page":"350","article-title":"Longterm cytological studies of copper IUD users","volume":"25","author":"Engineer AD","year":"1981","journal-title":"Acta Cytol"},{"key":"e_1_2_1_26_2","doi-asserted-by":"publisher","DOI":"10.1002\/dc.2840050302"},{"key":"e_1_2_1_27_2","first-page":"88","article-title":"Cytological studies in women using different types of hormonal contraceptives","volume":"5","author":"Engineer AD","year":"1980","journal-title":"J Ind Med Assoc"},{"key":"e_1_2_1_28_2","first-page":"190","article-title":"Cervico\u2010vaginal cytological evaluation in women receiving injections of noresthisterone oenanthate for contraception","volume":"38","author":"Engineer AD","year":"1988","journal-title":"J Obstet Gynaecol India"},{"key":"e_1_2_1_29_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(196404)17:4<508::AID-CNCR2820170412>3.0.CO;2-S"},{"key":"e_1_2_1_30_2","first-page":"629","article-title":"Cervical dysplasia: Biologic behavior","volume":"54","author":"Luthra UK","year":"1969","journal-title":"Indian J Med Res"},{"key":"e_1_2_1_31_2","doi-asserted-by":"publisher","DOI":"10.1097\/00003081-197012000-00005"}],"container-title":["Diagnostic Cytopathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fdc.2840070405","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/dc.2840070405","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,22]],"date-time":"2023-10-22T21:08:54Z","timestamp":1698008934000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/dc.2840070405"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1991,7]]},"references-count":30,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1991,7]]}},"alternative-id":["10.1002\/dc.2840070405"],"URL":"https:\/\/doi.org\/10.1002\/dc.2840070405","archive":["Portico"],"relation":{},"ISSN":["8755-1039","1097-0339"],"issn-type":[{"value":"8755-1039","type":"print"},{"value":"1097-0339","type":"electronic"}],"subject":[],"published":{"date-parts":[[1991,7]]}}}