{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T15:33:47Z","timestamp":1770824027214,"version":"3.50.1"},"reference-count":24,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2007,3,2]],"date-time":"2007-03-02T00:00:00Z","timestamp":1172793600000},"content-version":"vor","delay-in-days":5295,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostic Cytopathology"],"published-print":{"date-parts":[[1992,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Fine\u2010needle aspiration (FNA) cytology of lymph nodes in malignant lymphoma is fraught with difficulty. In certain clinical situations, cytology has been documented to be useful in patients with malignant lymphoma. The intent of our investigation was to determine the accuracy of a multiparameter approach in diagnosing lymphoma. We reviewed the results of FNA cytology combined with the immunocytochemistry and, in some cases, the Southern blots of aspirated cell suspensions obtained from 86 suspected lymphoma patients who subsequently underwent surgical biopsy of the aspirated site. In four cases, in which FNA was unable to retrieve sufficient material for diagnosis, the histology showed extensive fibrosis. When the FNA diagnoses were compared with the histologic diagnoses, the diagnosis concurred in 69 cases (56 malignant lymphomas, 12 reactive, 1 atypical lymphoid proliferation). There was one false\u2010positive, six false\u2010negatives, and eight cases diagnosed as atypical lymphoid proliferation. Overall accuracy was 91%. There were two types of false\u2010negative cases: those in which a diagnosis of another malignancy or unspecified malignant neoplasm was made and those that were diagnosed as reactive when the histology showed lymphoma. In seven cases, the DNA rearrangement studies of the antigen receptor genes were successfully performed on the aspirated cells and were useful in establishing lineage and clonality of both B and T lymphoid cells.<\/jats:p><jats:p>Our study indicated that the use of a multiparameter approach in the diagnosis of malignant lymphoma by FNA enhanced the accuracy of diagnosis of the non\u2010Hodgkin's lymphomas. In Hodgkin's disease, no benefit was derived from the approach. \u00a9 1992 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/dc.2840080506","type":"journal-article","created":{"date-parts":[[2007,2,22]],"date-time":"2007-02-22T02:08:19Z","timestamp":1172110099000},"page":"456-464","source":"Crossref","is-referenced-by-count":46,"title":["Accuracy of diagnosis of malignant lymphoma by combining fine\u2010needle aspiration cytomorphology with immunocytochemistry and in selected cases, southern blotting of aspirated cells: A tissue\u2010controlled study of 86 patients"],"prefix":"10.1002","volume":"8","author":[{"suffix":"Jr.","given":"Norberto","family":"Cartagena","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruth L.","family":"Katz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cheryl","family":"Hirsch\u2010Ginsberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Craig C.","family":"Childs","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nelson G.","family":"Ord\u00f3\u00f1ez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fernando","family":"Cabanillas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,3,2]]},"reference":[{"key":"e_1_2_1_2_2","volume-title":"Fine\u2010needle aspiration biopsy used as a direct adjunct in clinical diagnostic work","author":"Soderstrom N","year":"1966"},{"key":"e_1_2_1_3_2","volume-title":"Aspiration biopsy cytology, Part 1: Cytology of the supradiaphragmatic organs","author":"Zajicek J","year":"1974"},{"key":"e_1_2_1_4_2","volume-title":"Aspiration biopsy cytology, Part 2: Cytology of the supradiaphragmatic organs","author":"Zajicek J","year":"1979"},{"key":"e_1_2_1_5_2","first-page":"194","article-title":"The cytologic diagnosis of lymph node punctures","volume":"8","author":"Lopes Cardozo P","year":"1964","journal-title":"Acta Cytol (Baltimore)"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/22.3.255"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(86)90309-8"},{"key":"e_1_2_1_8_2","first-page":"848","article-title":"The role of FNA cytology in the diagnosis of lymphoma","volume":"32","author":"Carter T","year":"1988","journal-title":"Acta Cytol (Baltimore)"},{"key":"e_1_2_1_9_2","first-page":"329","article-title":"Fine needle aspiration biopsy of lymph nodes","volume":"23","author":"Pitts W","year":"1988","journal-title":"Pathol Annu"},{"key":"e_1_2_1_10_2","first-page":"337","article-title":"Limitations of aspiration cytology in the diagnosis of primary neoplasm","volume":"28","author":"Hajdu SI","year":"1984","journal-title":"Acta Cytol (Baltimore)"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19890215)63:4<703::AID-CNCR2820630418>3.0.CO;2-G"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19840201)53:3<553::AID-CNCR2820530330>3.0.CO;2-M"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1445-5994.1983.tb04482.x"},{"key":"e_1_2_1_14_2","first-page":"200","article-title":"Immunocytochemical analysis and cytomorphologic diagnosis on FNA of lymphoproliferative disease","volume":"32","author":"Tani E","year":"1988","journal-title":"Acta Cytol (Baltimore)"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/path.1711540306"},{"key":"e_1_2_1_16_2","first-page":"399","article-title":"Molecular genetic analysis in the diagnosis of lymphoma in fine needle aspiration biopsies. Part 2. Lymphomas vs non\u2010lymphoid malignant tumors","volume":"10","author":"Lubinski J","year":"1988","journal-title":"Anal Quant Cytol Histol"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/96.4.479"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1177\/29.4.6166661"},{"key":"e_1_2_1_19_2","first-page":"311","article-title":"Morphologic and immunocytochemical evaluation of 220 fine needle aspirates of malignant lymphoma and lymphoid hyperplasia","volume":"34","author":"Sneige N","year":"1990","journal-title":"Acta Cytol (Baltimore)"},{"key":"e_1_2_1_20_2","first-page":"31","volume-title":"Histochemistry in Pathologic Diagnosis","author":"Lee AK","year":"1987"},{"key":"e_1_2_1_21_2","first-page":"779","volume-title":"Manual of Clinical Laboratory Immunology","author":"Jaffe E","year":"1986"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.3109\/00313028209092117"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V65.5.1090.1090"},{"key":"e_1_2_1_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/0090-1229(88)90126-2"},{"key":"e_1_2_1_25_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/91.2.120"}],"container-title":["Diagnostic Cytopathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fdc.2840080506","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/dc.2840080506","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,23]],"date-time":"2023-10-23T12:57:40Z","timestamp":1698065860000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/dc.2840080506"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1992,9]]},"references-count":24,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1992,9]]}},"alternative-id":["10.1002\/dc.2840080506"],"URL":"https:\/\/doi.org\/10.1002\/dc.2840080506","archive":["Portico"],"relation":{},"ISSN":["8755-1039","1097-0339"],"issn-type":[{"value":"8755-1039","type":"print"},{"value":"1097-0339","type":"electronic"}],"subject":[],"published":{"date-parts":[[1992,9]]}}}