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This problem was clinically thought to represent gynecomastia, but a mammary fine\u2010needle aspiration biopsy demonstrated a malignant epithelial neoplasm composed of large granular amphophilic cells. Bile pigment was visualized in the tumor on aspirate smears and cell block preparations; immunostains showed reactivity for cytokeratin and alpha\u2010fetoprotein, but there was no positivity for epithelial membrane antigen, gross cystic disease fluid protein\u201015, vimentin, estrogen receptors, progesterone receptors, or S100 protein. These results indicated a diagnosis of metastatic HCC, which was subsequently confirmed by computed tomography of the abdomen. \u00a9 1992 wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/dc.2840080610","type":"journal-article","created":{"date-parts":[[2007,2,22]],"date-time":"2007-02-22T02:23:33Z","timestamp":1172111013000},"page":"588-592","source":"Crossref","is-referenced-by-count":10,"title":["Metastatic hepatocellular carcinoma of the breast, simulating gynecomastia: Diagnosis by fine\u2010needle aspiration biopsy"],"prefix":"10.1002","volume":"8","author":[{"given":"Oscar","family":"Nappi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerardo","family":"Ferrara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Lanniello","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark 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