{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,6]],"date-time":"2025-12-06T07:07:20Z","timestamp":1765004840970},"reference-count":12,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2006,7,12]],"date-time":"2006-07-12T00:00:00Z","timestamp":1152662400000},"content-version":"vor","delay-in-days":5001,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostic Cytopathology"],"published-print":{"date-parts":[[1992,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>On fine\u2010needle aspiration (FNA), fibroadenomas have a characteristic cytological appearance, although occasional cases are misinterpreted as carcinomas and vice versa. In a review of 521 breast aspirates correlated with the subsequent histology, six of 87 fibroadenomas (7%) were malignant or suspicious of malignancy on FNA (false positives). Following cytological review, four were still suspicious of malignancy because of cellular dyscohesion and prominent nucleoli, while two were fibroadenomas. On FNA, four of 145 carcinomas (3%) were diagnosed as fibroadenomas (false negatives). On review, three were malignant or suspicious of malignancy, while one was consistent with a fibroadenoma. Three false negative diagnoses were due to underappreciation of single malignant cells present between epithelial groupings typical of a fibroadenoma, while one was due to undersampling of the carcinoma. Cytologically, some fibroadenomas are sufficiently atypical that histological confirmation is necessary to exclude a malignancy. Misinterpreting carcinomas as fibroadenomas could be avoided by careful study of the morphology of isolated cells.<\/jats:p>","DOI":"10.1002\/dc.2840080623","type":"journal-article","created":{"date-parts":[[2007,2,22]],"date-time":"2007-02-22T02:23:33Z","timestamp":1172111013000},"page":"643-647","source":"Crossref","is-referenced-by-count":46,"title":["Fibroadenoma of the breast: Diagnostic pitfalls of fine\u2010needle aspiration"],"prefix":"10.1002","volume":"8","author":[{"given":"Janine L","family":"Benoit","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosemin","family":"Kara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Elizabeth McGregor","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M\u00e1ire A.","family":"Duggan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,12]]},"reference":[{"issue":"2","key":"e_1_2_1_2_2","first-page":"23","article-title":"Fine needle aspiration in management of breast masses","volume":"24","author":"Layfield LI","year":"1989","journal-title":"Pathol Annu"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/89.6.707"},{"issue":"1","key":"e_1_2_1_4_2","first-page":"375","article-title":"Fine needle aspiration of the breast: diagnostic criteria","volume":"18","author":"Oertel YC","year":"1983","journal-title":"Pathol Annu"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/dc.2840060602"},{"key":"e_1_2_1_6_2","first-page":"156","article-title":"Fine needle aspiration cytology of breast masses: an evaluation of its accuracy and reasons for diagnostic failure","volume":"69","author":"Patel JJ","year":"1987","journal-title":"Ann R Coll Physicians Engl"},{"key":"e_1_2_1_7_2","first-page":"1217","volume-title":"Ackerman's surgical pathology","author":"Rosai JR","year":"1989"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.1800760424"},{"key":"e_1_2_1_9_2","first-page":"1200","volume-title":"Ackerman's surgical pathology","author":"Rosai JR","year":"1989"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/dc.2840060602"},{"key":"e_1_2_1_11_2","first-page":"590","article-title":"Occurrence of breast carcinoma within a fibroadenoma: a review","volume":"108","author":"Pick PW","year":"1984","journal-title":"Arch Pathol Lab Med"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19861001)58:7<1493::AID-CNCR2820580720>3.0.CO;2-F"},{"key":"e_1_2_1_13_2","first-page":"32","volume-title":"Guides to clinical aspiration Biopsy\u2010breast","author":"Kline TS","year":"1989"}],"container-title":["Diagnostic Cytopathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fdc.2840080623","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/dc.2840080623","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,25]],"date-time":"2023-09-25T21:59:34Z","timestamp":1695679174000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/dc.2840080623"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1992,11]]},"references-count":12,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1992,11]]}},"alternative-id":["10.1002\/dc.2840080623"],"URL":"https:\/\/doi.org\/10.1002\/dc.2840080623","archive":["Portico"],"relation":{},"ISSN":["8755-1039","1097-0339"],"issn-type":[{"value":"8755-1039","type":"print"},{"value":"1097-0339","type":"electronic"}],"subject":[],"published":{"date-parts":[[1992,11]]}}}