{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T15:00:18Z","timestamp":1770822018073,"version":"3.50.1"},"reference-count":36,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2006,7,12]],"date-time":"2006-07-12T00:00:00Z","timestamp":1152662400000},"content-version":"vor","delay-in-days":4940,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostic Cytopathology"],"published-print":{"date-parts":[[1993,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We have reviewed the effusion cytology of 51 cases of histologically proven malignant mesothelioma of the pleura (49 cases) and the peritoneum (2 cases). The patient group included 45 males and 6 females, aged 45\u201083 yr. A cytological diagnosis of malignancy had been rendered on 43 cases, and in 30 of them it was consistent with, or at least suggestive of, a mesothelioma. Diagnostic clues, especially evident in epithelial and biphasic tumors were hypercellularity and\/or morular aggregates of malignant cells showing scalloped borders and nuclei with dense chromatin and evident nucleoli. Cytomegaly with multinucleation was also frequently observed. Reactive mesothelial cells were often present along with other non specific features such as red blood cells, fibrin, necrotic debris. In 13 cases, a diagnosis of malignancy was entertained but mesothelioma, although considered, was not reported out because of scantiness of material. In four cases, adenocarcinoma was erroneously diagnosed for the presence of deceptive cell vacuoles. In eight cases, no diagnostic cells were recovered in repeated effusions. The first diagnosis was a cytologic one in 37 patients. Tissue study was performed on autopsy (35 patients) and surgical material. The latter was the only source of histology in six cases. Immunocytochemical investigation was negative for carcinoembryonic antigen in all but one tested cases (1\/21) and positive for human milk fat globulin in about one\u2010half of the epithelial and biphasic tumors. In 18 of 21 cases, positivity for combined high\u2010and low\u2010molecular\u2010weight keratins was detected. The results of our survey indicate that conventional cytology permits accurate identification of either reactive and neoplastic mesothelial cells. The distinction between mesothelioma and adenocarcinoma may be further attempted using immunocytochemistry, combining a few commonly available markers, although the results should be carefully evaluated in view of their lack of specificity.<\/jats:p>","DOI":"10.1002\/dc.2840090106","type":"journal-article","created":{"date-parts":[[2007,2,22]],"date-time":"2007-02-22T03:11:32Z","timestamp":1172113892000},"page":"25-31","source":"Crossref","is-referenced-by-count":34,"title":["Cytopathology of malignant mesothelioma: A study of its patterns and histological bases"],"prefix":"10.1002","volume":"9","author":[{"given":"Luigi","family":"Dibonito","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanni","family":"Falconieri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isabella","family":"Colautti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniela Bonifacio","family":"Gori","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandra","family":"Dudine","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luigi","family":"Giarelli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,12]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19861001)58:7<1540::AID-CNCR2820580727>3.0.CO;2-5"},{"key":"e_1_2_1_3_2","volume-title":"Tumors and Pseudotumors of the serous Membranes","author":"McCaughey WTE","year":"1985"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.1800570903"},{"key":"e_1_2_1_5_2","first-page":"427","article-title":"The clinical aspects of mesothelioma","volume":"45","author":"Elmes PC","year":"1976","journal-title":"Q J Med"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.37.11.1215"},{"key":"e_1_2_1_7_2","first-page":"807","article-title":"Immunohistochemical differentiation of malignant mesothelioma, mesothelial hyperplasia and metastatic adenocarcinoma in serous effusions, utilizing staining for carcinoembryonic antigen, keratin and vimentin","volume":"31","author":"Duggan MA","year":"1987","journal-title":"Acta Cytol"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-198706000-00005"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/88.5.610"},{"key":"e_1_2_1_10_2","first-page":"103","article-title":"Discrimination between primary pleural and primary peritoneal mesotheliomas by morphometry and analysis of the vacuolization pattern of the exfoliated mesothelial cells","volume":"26","author":"Boon ME","year":"1982","journal-title":"Acta Cytol"},{"key":"e_1_2_1_11_2","first-page":"196","article-title":"The cytologic diagnosis of mesothelioma","volume":"3","author":"Ehya H","year":"1986","journal-title":"Semin Diagn Pathol"},{"key":"e_1_2_1_12_2","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1177\/29.4.6166661","article-title":"Use of Avidin\u2010Biotin\u2010Peroxidase Complex (ABC) in immunoperoxdase techniques","volume":"29","author":"Hsu S","year":"1981","journal-title":"J Histochem Cytochem"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000372-198602000-00006"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajim.4700160405"},{"key":"e_1_2_1_15_2","unstructured":"GiarelliL Bianchi GrandiGMalignant mesothelioma of the pleura in Trieste.Am J Ind Med In press."},{"key":"e_1_2_1_16_2","first-page":"329","article-title":"The positive pleural effusion: A retrospective study of cytopathologic diagnoses with autopsy confirmation","volume":"36","author":"Di Bonito L","year":"1992","journal-title":"Acta Cytol"},{"key":"e_1_2_1_17_2","first-page":"591","article-title":"Intracranial metastases from malignant pleural mesothelioma. Report of three autopsy cases and review of the literature","volume":"115","author":"Falconieri G","year":"1991","journal-title":"Arch Pathol Lab Med"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19820601)49:11<2431::AID-CNCR2820491134>3.0.CO;2-W"},{"key":"e_1_2_1_19_2","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1016\/S0022-5223(19)40189-X","article-title":"Malignant pleural mesothelioma. Report of 19 cases","volume":"71","author":"Shearin JC","year":"1976","journal-title":"J Thorac Cardiovasc Surg"},{"key":"e_1_2_1_20_2","first-page":"845","article-title":"Effusion cytology in the diagnosis of malignant epithelioid and biphasic pleural mesothelioma","volume":"114","author":"Sherman ME","year":"1990","journal-title":"Arch Palhol Lab Med"},{"key":"e_1_2_1_21_2","first-page":"37","article-title":"Malignant mesothelioma. Cytopathology of 75 cases seen in a New Jersey community hospital","volume":"28","author":"Triol JH","year":"1984","journal-title":"Acta Cytol"},{"key":"e_1_2_1_22_2","first-page":"209","article-title":"The cytopathology of mesothelioma","volume":"23","author":"Tao L","year":"1979","journal-title":"Acta Cytol"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(196207\/08)15:4<691::AID-CNCR2820150403>3.0.CO;2-L"},{"key":"e_1_2_1_24_2","doi-asserted-by":"publisher","DOI":"10.1136\/thx.33.1.26"},{"key":"e_1_2_1_25_2","first-page":"541","volume-title":"Comprehensive cytopathology","author":"Naylor B","year":"1991"},{"key":"e_1_2_1_26_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19900115)65:2<292::AID-CNCR2820650218>3.0.CO;2-W"},{"key":"e_1_2_1_27_2","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.25.7.577"},{"key":"e_1_2_1_28_2","unstructured":"KweeWS VeldhuizenRW AlousCA MorawetzF BoonMEQuantitative and qualitative differences between benign and maliognant mesothelial cells in pleural fluid.Acta Cytol1982:401\u2013406."},{"key":"e_1_2_1_29_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-198601000-00005"},{"key":"e_1_2_1_30_2","doi-asserted-by":"publisher","DOI":"10.1002\/path.1700860204"},{"key":"e_1_2_1_31_2","doi-asserted-by":"publisher","DOI":"10.1002\/path.1711430303"},{"key":"e_1_2_1_32_2","first-page":"288","article-title":"An unusual cytologic presentation of mesothelioma in serous effusions","volume":"27","author":"Spriggs AI","year":"1983","journal-title":"Acta Cytol"},{"key":"e_1_2_1_33_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-198404000-00004"},{"key":"e_1_2_1_34_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19850415)55:8<1679::AID-CNCR2820550812>3.0.CO;2-C"},{"key":"e_1_2_1_35_2","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.42.11.1184"},{"key":"e_1_2_1_36_2","first-page":"625","article-title":"Oncofetal antigens as tumor markers in the cytologic diagnosis of effusions","volume":"27","author":"Orell SR","year":"1983","journal-title":"Acta Cytol"},{"key":"e_1_2_1_37_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19840901)54:5<951::AID-CNCR2820540536>3.0.CO;2-A"}],"container-title":["Diagnostic Cytopathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fdc.2840090106","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/dc.2840090106","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,25]],"date-time":"2023-10-25T16:47:03Z","timestamp":1698252423000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/dc.2840090106"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1993,1]]},"references-count":36,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1993,1]]}},"alternative-id":["10.1002\/dc.2840090106"],"URL":"https:\/\/doi.org\/10.1002\/dc.2840090106","archive":["Portico"],"relation":{},"ISSN":["8755-1039","1097-0339"],"issn-type":[{"value":"8755-1039","type":"print"},{"value":"1097-0339","type":"electronic"}],"subject":[],"published":{"date-parts":[[1993,1]]}}}