{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T03:31:36Z","timestamp":1774582296426,"version":"3.50.1"},"reference-count":12,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2006,7,12]],"date-time":"2006-07-12T00:00:00Z","timestamp":1152662400000},"content-version":"vor","delay-in-days":4667,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostic Cytopathology"],"published-print":{"date-parts":[[1993,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>This report details the cytologic features of primary localized amyloid tumor of the breast presenting as bilateral breast masses in a 72\u2010yr\u2010old woman. Clinically and radiographically, the masses simulated metastatic or multifocal carcinoma. Fine\u2010needle aspiration revealed irregular globules of acellular amorphous material and numerous multinucleated giant cells resembling granulomatous inflammation. Histology confirmed amyloid tumors with a foreign\u2010body giant cell reaction in response to amyloid and foci of osseous metaplasia. Subsequent clinical workup included a serum electrophoresis and immunofixation which showed a small IgG k monoclonal protein. Urine immunofixation was negative for Bence Jones protein. Bone marrow examination revealed no evidence of a plasma cell dyscrasia. To date the patient has not developed clinical or laboratory evidence of systemic amyloidosis or multiple myeloma. Amyloidosis involving the breast and specifically localized primary amyloid tumors of the breast are rare and infrequently reported entities. To our knowledge, osseous metaplasia within isolated primary amyloid tumors of the breast has not been reported. We present this unusual case to illustrate the intratumoral calcification patterns mimicking carcinoma and to characterize the cytologic features. Emphasis is placed on the inclusion of amyloidosis in the differential diagnosis of breast masses.<\/jats:p>","DOI":"10.1002\/dc.2840090521","type":"journal-article","created":{"date-parts":[[2007,2,22]],"date-time":"2007-02-22T03:01:03Z","timestamp":1172113263000},"page":"570-575","source":"Crossref","is-referenced-by-count":34,"title":["Localized primary amyloid tumor associated with osseous metaplasia presenting as bilateral breast masses: Cytologic and radiologic features"],"prefix":"10.1002","volume":"9","author":[{"given":"Lori A.","family":"Lynch","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ann T.","family":"Moriarty","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,12]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01881064"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198006053022305"},{"key":"e_1_2_1_4_2","first-page":"102","article-title":"Amyloid tumor of the breast","volume":"95","author":"Fernandez BB","year":"1973","journal-title":"Arch Pathol"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-197806000-00003"},{"key":"e_1_2_1_6_2","first-page":"7","article-title":"Primary amyloid tumor of the breast: case report and literature review","volume":"29","author":"Lew W","year":"1985","journal-title":"Acta Cytol"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-198608000-00003"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0009-9260(05)80512-4"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19870315)59:6<1201::AID-CNCR2820590628>3.0.CO;2-P"},{"key":"e_1_2_1_10_2","first-page":"43","article-title":"The potassium permanganate method: a reliable method for differentiating amyloid AA from other forms of amyloid in routine laboratory practice","volume":"97","author":"Van Rijswijk MH","year":"1979","journal-title":"Am J Pathol"},{"key":"e_1_2_1_11_2","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1093\/ajcp\/62.4.472","article-title":"Rheumatoid arthritis, bilateral amyloid tumors of the breast, and multiple cutaneous amyloid nodules","volume":"62","author":"Sadeghee SA","year":"1974","journal-title":"Am J Clin Pathol"},{"key":"e_1_2_1_12_2","first-page":"60","article-title":"Amyloid deposit in the carcinoma of breast","volume":"7","author":"Patil SD","year":"1970","journal-title":"Indian J Cancer"},{"key":"e_1_2_1_13_2","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1093\/ajcp\/58.3.231","article-title":"Tubular carcinoma of the breast: a clinicopathologic study of 35 cases","volume":"5","author":"Carsten PHB","year":"1972","journal-title":"Am J Clin Pathol"}],"container-title":["Diagnostic Cytopathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fdc.2840090521","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/dc.2840090521","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,25]],"date-time":"2023-10-25T15:46:10Z","timestamp":1698248770000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/dc.2840090521"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1993,10]]},"references-count":12,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1993,10]]}},"alternative-id":["10.1002\/dc.2840090521"],"URL":"https:\/\/doi.org\/10.1002\/dc.2840090521","archive":["Portico"],"relation":{},"ISSN":["8755-1039","1097-0339"],"issn-type":[{"value":"8755-1039","type":"print"},{"value":"1097-0339","type":"electronic"}],"subject":[],"published":{"date-parts":[[1993,10]]}}}