{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T18:38:13Z","timestamp":1760121493413},"reference-count":18,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2006,7,12]],"date-time":"2006-07-12T00:00:00Z","timestamp":1152662400000},"content-version":"vor","delay-in-days":4151,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostic Cytopathology"],"published-print":{"date-parts":[[1995,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The cytologic findings in 13 cases of cervical adenocarcinoma in situ (mean age 33.9 yr) were compared with those in 9 cases of cervical invasive adenocarcinoma (mean age 45.7 yr). All diagnoses were confirmed by biopsy. the major differences found were that a necrotic background (66% invasive vs. 0% in situ) and macronucleoli (77% invasive vs. 0% in situ) were more common in invasive cases, whereas associated squamous\u2010cell dysplasia (69% in situ vs. 0% invasive) was more common in in situ cases. Other differences included syncytial tissue fragments with irregular cell borders, frequent cell drop\u2010off, and markedly atypical single columnar cells (or markedly atypical naked nuclei) seen more commonly in invasive cases, whereas monolayer sheets and\/or syncytial tissue fragments with smooth borders and rare cell drop\u2010off were more common in in situ cases. Although none of these features is diagnostic individually, in combination they are helpful in distinguishing between in situ and invasive adenocarcinoma.<\/jats:p><jats:p>Nine of 13 of the in situ cases showed associated squamous\u2010cell dysplasia. in all nine of these cases, the glandular dysplasia was overlooked or underestimated in severity on original cytologic diagnosis. This suggests that the presence of a squamous lesion may lead to decreased detection of glandular lesions, perhaps because the features of squamous lesions are more well known; thus they are more easily recognized, at the expense of glandular lesions. All invasive adenocarcinomas were identified as carcinoma in the original diagnosis with seven specified as invasive adenocarcinomas. \u00a9 1995 Wiley\u2010 Liss, Inc.<\/jats:p>","DOI":"10.1002\/dc.2840120206","type":"journal-article","created":{"date-parts":[[2007,2,22]],"date-time":"2007-02-22T03:34:11Z","timestamp":1172115251000},"page":"120-125","source":"Crossref","is-referenced-by-count":16,"title":["Comparative cytologic findings of in situ and invasive adenocarcinoma of the uterine cervix"],"prefix":"10.1002","volume":"12","author":[{"given":"S.","family":"Keyhani\u2010Rofagha","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Brewer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patricia","family":"Prokorym","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,12]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197412)34:6<2018::AID-CNCR2820340621>3.0.CO;2-B"},{"issue":"3","key":"e_1_2_1_3_2","first-page":"190","article-title":"Endocervical glandular dysplasia, adenocarcinoma in situ, and early invasive (microinvasive) adenocarcinoma of the uterine cervix","volume":"7","author":"Jaworski RC","year":"1990","journal-title":"Semin Diagn Pathol"},{"issue":"3","key":"e_1_2_1_4_2","first-page":"205","article-title":"Invasive adenocarcinoma and related tumors of the uterine cervix","volume":"7","author":"Young RH","year":"1990","journal-title":"Semin Diagn Pathol"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1097\/00006250-198906000-00015"},{"issue":"1","key":"e_1_2_1_6_2","first-page":"4","article-title":"Oral contraceptive use and risk of invasive cervical cancer","volume":"19","author":"Brinton LA","year":"1990","journal-title":"Acta Epiderm"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.1890310404"},{"issue":"1","key":"e_1_2_1_8_2","first-page":"127","article-title":"Cervicovaginal cytology in uterine adenocarcinoma and adenosquamous carcinoma: comparison of cytologic and histologic findings","volume":"35","author":"Costa MJ","year":"1991","journal-title":"Acta Cytol"},{"issue":"1","key":"e_1_2_1_9_2","first-page":"117","article-title":"Comparative cytologic features of adenocarcinoma in situ of the uterine cervix","volume":"35","author":"Lee KR","year":"1991","journal-title":"Acta Cytol"},{"issue":"1","key":"e_1_2_1_10_2","first-page":"109","article-title":"Morphology of adenocarcinoma in situ and microinvasive adenocarcinoma of the uterine cervix: a cytologic and ultrastructural study","volume":"35","author":"Kudo R","year":"1991","journal-title":"Acta Cytol"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19870215)59:4<862::AID-CNCR2820590434>3.0.CO;2-P"},{"issue":"3","key":"e_1_2_1_12_2","first-page":"325","article-title":"The cytologic diagnosis of adenocarcinoma in situ of the cervix uteri and related lesions. III. Pitfalls in diagnosis","volume":"32","author":"Pacey F","year":"1988","journal-title":"Acta Cytol"},{"issue":"4","key":"e_1_2_1_13_2","first-page":"397","article-title":"The cytologic diagnosis of adenocarcinoma in situ of the cervix uteri and related lesions. I. Adenocarcinoma in situ","volume":"31","author":"Ayer B","year":"1987","journal-title":"Acta Cytol"},{"issue":"2","key":"e_1_2_1_14_2","first-page":"115","article-title":"Early endocervical glandular neoplasia. I. Histomorphology and cytomorphology","volume":"30","author":"Betsill WL","year":"1986","journal-title":"Acta Cytol"},{"issue":"2","key":"e_1_2_1_15_2","first-page":"127","article-title":"Early endocervical glandular neoplasia. II. Morphometric analysis of the cells","volume":"30","author":"Clark AH","year":"1986","journal-title":"Acta Cytol"},{"issue":"4","key":"e_1_2_1_16_2","first-page":"461","article-title":"Exfoliative cytology of in situ and microinvasive adenocarcinoma of the uterine cervix","volume":"28","author":"Nguyen GK","year":"1984","journal-title":"Acta Cytol"},{"issue":"4","key":"e_1_2_1_17_2","first-page":"283","article-title":"Expanded cytologic criteria for the diagnosis of adenocarcinoma in situ of the cervix and related lesions","volume":"24","author":"Bousfield L","year":"1980","journal-title":"Acta Cytol"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0344-0338(11)80763-6"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/0090-8258(89)90602-1"}],"container-title":["Diagnostic Cytopathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fdc.2840120206","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/dc.2840120206","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,26]],"date-time":"2023-10-26T14:37:49Z","timestamp":1698331069000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/dc.2840120206"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1995,3]]},"references-count":18,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1995,3]]}},"alternative-id":["10.1002\/dc.2840120206"],"URL":"https:\/\/doi.org\/10.1002\/dc.2840120206","archive":["Portico"],"relation":{},"ISSN":["8755-1039","1097-0339"],"issn-type":[{"value":"8755-1039","type":"print"},{"value":"1097-0339","type":"electronic"}],"subject":[],"published":{"date-parts":[[1995,3]]}}}