{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T03:20:24Z","timestamp":1761708024923},"reference-count":9,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2006,7,12]],"date-time":"2006-07-12T00:00:00Z","timestamp":1152662400000},"content-version":"vor","delay-in-days":4090,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostic Cytopathology"],"published-print":{"date-parts":[[1995,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The use of endocervical brushes has led to a generous sampling of both endocervical and \u201clower uterine segment\u201d (LUS) cells. to an unfamiliar eye, the large fragments of endometrial tissue from the LUS may lead to misinterpretation as endometriosis or glandular malignancy, as happened in our institution when the use of endocervical brush and recognition of LUS cells in cervical smears were limited. Eight cases, cytologically interpreted as such, were proven to be benign following cervical biopsy or endometrial curettage. the nature of LUS cells was recognized only on retrospective review of this cytologic material. However, in recent years, routine use of the endocervical brush resulted in an influx of similar cases referred by the cytotechnologists to the pathologist as glandular atypia. Thus, to get familiarized with the cytomorphology of LUS cells and its diagnostic pitfalls, a prospective study was undertaken. This entailed a review of 62,187 consecutive cervicovaginal smears (women of post\u2010hysterectomy status were excluded) received within a 12\u2010mo period (July 1, 1992\u2010June 30, 1993). A total of 344 smears (0.55%) showed large tissue fragments of branching tubular endometrial glands with and without surrounding stroma. Patients ranged from 14\u201382 yr of age. History of cervical cone biopsy was noted in nine patients (2.6%). Repeat cervical smear or concurrent endometrial or endocervical biopsy available in 84 patients (24.4%) were negative. LUS cells may be mistaken for endometriosis, epithelial glandular atypia, as well as carcinoma of both endocervical and endometrial origin. in addition to glandular abnormality, LUS cells may also be misinterpreted as that of squamous intraepithelial lesion. the characteristic presentation of LUS cells with long tubular branching glands embedded in a loose monomorphic stromal cells containing delicate capillaries is best appreciated at low power magnification. Familiarity with the cytomorphologic features of LUS and awareness of the diagnostic pitfalls may avoid interpretative errors and unnecessary surgical procedures. \u00a9 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/dc.2840120315","type":"journal-article","created":{"date-parts":[[2007,2,22]],"date-time":"2007-02-22T03:34:06Z","timestamp":1172115246000},"page":"263-268","source":"Crossref","is-referenced-by-count":51,"title":["Endometrial cells of the \u201cLower uterine segment\u201d (LUS) in cervical smears obtained by endocervical brushings: A source of potential diagnostic pitfall"],"prefix":"10.1002","volume":"12","author":[{"given":"Prabodh","family":"Gupta","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariza N.","family":"De Peralta\u2010Venturino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Jane Purslow","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sudha R.","family":"Kini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,12]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"1442","volume-title":"Gray's Anatomy","author":"Williams P","year":"1989"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/00003081-196606000-00006"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.1991.tb01452.x"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/dc.2840090121"},{"key":"e_1_2_1_6_2","first-page":"325","article-title":"The cytologic diagnosis of adenocarcinoma in situ of the cervix uteri and related lesions. III. Pitfalls in diagnosis","volume":"32","author":"Pacey F","year":"1988","journal-title":"Acta Cytol"},{"key":"e_1_2_1_7_2","first-page":"57A","article-title":"Tubal metaplasia of the endocervix (TEM): a prevalence study [abstract]","volume":"4","author":"Jonasson J","year":"1991","journal-title":"Mod Pathol"},{"key":"e_1_2_1_8_2","first-page":"1","article-title":"Tubal metaplasia. A frequent potential pitfall in the cytologic diagnosis of endocervical glandular dysplasia on cervical smears","volume":"36","author":"Novotny D","year":"1992","journal-title":"Acta Cytol"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.1993.tb00099.x"},{"key":"e_1_2_1_10_2","first-page":"705","article-title":"Atypical glandular cells in cervical smears from women who have undergone cone biopsy","volume":"37","author":"Lee K","year":"1993","journal-title":"Acta Cytol"}],"container-title":["Diagnostic Cytopathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fdc.2840120315","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/dc.2840120315","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,25]],"date-time":"2023-10-25T14:14:14Z","timestamp":1698243254000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/dc.2840120315"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1995,5]]},"references-count":9,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1995,5]]}},"alternative-id":["10.1002\/dc.2840120315"],"URL":"https:\/\/doi.org\/10.1002\/dc.2840120315","archive":["Portico"],"relation":{},"ISSN":["8755-1039","1097-0339"],"issn-type":[{"value":"8755-1039","type":"print"},{"value":"1097-0339","type":"electronic"}],"subject":[],"published":{"date-parts":[[1995,5]]}}}