{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T00:11:15Z","timestamp":1789171875710,"version":"build-2803163510"},"reference-count":21,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,8,23]],"date-time":"2025-08-23T00:00:00Z","timestamp":1755907200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,8,23]],"date-time":"2025-08-23T00:00:00Z","timestamp":1755907200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diagnostic Cytopathology"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Intrathyroidal thymic carcinoma (ITTC) is a rare malignant thyroid tumor that is similar to thymus epithelium\u2010related tumors. Herein, we report a case of ITTC diagnosed by fine\u2010needle aspiration cytology (FNA). A 55\u2010year\u2010old male presented with a slowly increasing cervical mass. Cervical ultrasonography revealed an irregular mass measuring 3.7\u2009\u00d7\u20092.5\u2009\u00d7\u20092.1\u2009cm. FNA was performed. Cytological findings showed that the tumor was highly cellular and tumor cells were arranged in islet\u2010like clusters accompanied by lymphocytes. The tumor cells had a high nuclear\u2010to\u2010cytoplasmic ratio. The nuclei were round to ovoid or spindle\u2010shaped. The fusiform tumor cells exhibited a regular streaming arrangement, similar to squamous cell carcinoma. Immunocytochemically, the tumor cells were positive for CD5 and c\u2010KIT. Pathological examination of the resected thyroid specimen revealed confluent cell nests of epithelioid and spindle cells with significant lymphocyte and plasma cell infiltration throughout the tumor. Immunohistochemically, the tumor cells were positive for cytokeratin, CD5, c\u2010KIT, and p63, and negative for TTF\u20101 and thyroglobulin. Therefore, the tumor was diagnosed as ITTC. Although ITTC is rare, it should be considered in the differential diagnosis of a mass in the lower pole of the thyroid gland that exhibits large cohesive islet\u2010like clusters with numerous lymphocytes and features resembling those of squamous cell carcinoma.<\/jats:p>","DOI":"10.1002\/dc.70011","type":"journal-article","created":{"date-parts":[[2025,8,23]],"date-time":"2025-08-23T18:39:42Z","timestamp":1755974382000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Preoperative Cytological Diagnosis of Intrathyroidal Thymic Carcinoma: A Case Report With Review of the Literature"],"prefix":"10.1002","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1237-083X","authenticated-orcid":false,"given":"Makoto","family":"Yamada","sequence":"first","affiliation":[{"name":"Department of Clinical Laboratory Seirei Hamamatsu General Hospital  Hamamatsu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shota","family":"Sezaki","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory Seirei Hamamatsu General Hospital  Hamamatsu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomonari","family":"Ikeya","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory Seirei Hamamatsu General Hospital  Hamamatsu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masatoshi","family":"Furuta","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory Seirei Hamamatsu General Hospital  Hamamatsu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shogo","family":"Mizuno","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory Seirei Hamamatsu General Hospital  Hamamatsu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshiro","family":"Otsuki","sequence":"additional","affiliation":[{"name":"Department of Pathology Seirei Hamamatsu General Hospital  Hamamatsu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,8,23]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0339(199805)18:5<377::AID-DC16>3.0.CO;2-F"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01656263"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0046-8177(91)90083-2"},{"key":"e_1_2_11_5_1","volume-title":"WHO Classification of Tumours, Pathology and Genetics, Tumours of Endocrine Organs","author":"DeLellis R. 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American Journal of Neuroradiology"},{"issue":"2","key":"e_1_2_11_12_1","first-page":"313","article-title":"Carcinoma Showing Thymuslike Element of the Thyroid","volume":"47","author":"Nassar A.","year":"2003","journal-title":"Acta Cytologica"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2005.15.1383"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.20237"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1827.2008.02310.x"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1607-551X(09)70020-8"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1507\/endocrj.K07E-147"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.4132\/KoreanJPathol.2012.46.3.302"},{"issue":"5","key":"e_1_2_11_19_1","first-page":"543","article-title":"Intrathyroid Epithelial Thymoma (ITET) and Carcinoma Showing Thymus\u2010Like Differentiation (CASTLE): CD5\u2010Positive Neoplasms Mimicking Squamous Cell Carcinoma of the Thyroid","volume":"28","author":"Kakudo K.","year":"2013","journal-title":"Histology and Histopathology"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2011.0415"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1159\/000448836"},{"issue":"2","key":"e_1_2_11_22_1","first-page":"259","article-title":"Histopathological Study of Carcinoma Showing Thymus\u2010Like Differentiation (CASTLE)","volume":"42","author":"Okubo Y.","year":"2020","journal-title":"Malaysian Journal of Pathology"}],"container-title":["Diagnostic Cytopathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/dc.70011","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/dc.70011","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/dc.70011","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T23:30:27Z","timestamp":1789169427000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/dc.70011"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,23]]},"references-count":21,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2025,11]]}},"alternative-id":["10.1002\/dc.70011"],"URL":"https:\/\/doi.org\/10.1002\/dc.70011","archive":["Portico"],"relation":{},"ISSN":["8755-1039","1097-0339"],"issn-type":[{"value":"8755-1039","type":"print"},{"value":"1097-0339","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,23]]},"assertion":[{"value":"2024-11-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-08-16","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-08-23","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}