{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T00:11:58Z","timestamp":1789171918395,"version":"build-2803163510"},"reference-count":37,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,8,21]],"date-time":"2025-08-21T00:00:00Z","timestamp":1755734400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,8,21]],"date-time":"2025-08-21T00:00:00Z","timestamp":1755734400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diagnostic Cytopathology"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Endoscopic ultrasound\u2010guided fine\u2010needle aspiration (EUS\u2010FNA) and endoscopic ultrasound\u2010guided fine\u2010needle biopsy (EUS\u2010FNB) are widely used for the diagnosis of pancreatic tumors. The aim of our study was to compare the diagnostic performance of EUS\u2010FNA and EUS\u2010FNB for the diagnosis of pancreatic neuroendocrine (NE) neoplasms and to review tumors' cytopathology.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Patients who underwent EUS\u2010FNA and EUS\u2010FNB for pancreatic NE neoplasms were reviewed retrospectively. Sample adequacy, diagnostic yield (defined as percentage of definitive diagnosis) and sensitivity were compared between FNA and FNB. The common cytologic features of pancreatic NE neoplasms were reviewed and quantified.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 72 patients were diagnosed with pancreatic NE neoplasms at our institution by EUS\u2010FNA and EUS\u2010FNB. The mean age at diagnosis was 57.5\u2009years. The proportions of adequate samples were 68\/68 (100%) for EUS\u2010FNA and 57\/58 (98.3%) for EUS\u2010FNB. EUS\u2010FNB demonstrated a higher diagnostic yield than FNA, 57\/58 (98.3%) for EUS\u2010FNB and 61\/68 (89.7%) for EUS\u2010FNA. When concurrent EUS\u2010FNBs were performed, the diagnostic yield increased to 97.1% with an incremental increase of 5\/68 (7.4%) relative to EUS\u2010FNA alone. When sensitivity was defined as the ability to identify cytological atypia and above categories, the sensitivity for EUS\u2010FNA and EUS\u2010FNB was 98.5% and 91.4%, respectively. The grading of well\u2010differentiated neuroendocrine tumors was 32\/51 Grade 1 tumors (62.7%) and 19\/51 Grade 2 tumors (37.3%). Four patients were found to have poorly differentiated neuroendocrine carcinomas.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>EUS\u2010FNA and EUS\u2010FNB were comparable in sample adequacy for diagnosing pancreatic NE neoplasms. EUS\u2010FNA appeared to have higher sensitivity but lower diagnostic yield than EUS\u2010FNB in our study.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/dc.70012","type":"journal-article","created":{"date-parts":[[2025,8,21]],"date-time":"2025-08-21T12:00:17Z","timestamp":1755777617000},"page":"546-554","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Endoscopic Ultrasound\u2010Guided Fine\u2010Needle Aspiration and Biopsy in the Diagnosis of Pancreatic Neuroendocrine Neoplasms: A Series of 72 Cases"],"prefix":"10.1002","volume":"53","author":[{"given":"John","family":"Findley","sequence":"first","affiliation":[{"name":"Department of Pathology Rush University Medical Center  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hamideh","family":"Doozandeh","sequence":"additional","affiliation":[{"name":"Department of Pathology Rush University Medical Center  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucas","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Pathology Rush University Medical Center  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Pathology Rush University Medical Center  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7385-1242","authenticated-orcid":false,"given":"Lei","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Pathology Rush University Medical Center  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,8,21]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2007.15.4377"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.23648"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdn351"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000003478"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2016.03.1405"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1159\/000510755"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2012.03.1392"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1055\/s\u20100043\u2010101693"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1177\/0284185117725367"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11547\u2010021\u201001333\u2010z"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamcollsurg.2007.12.040"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00428\u2010004\u20101037\u2010x"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478\u2010200105000\u201000006"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.pas.0000184819.71752.ad"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078\u20100432.CCR\u201016\u20101113"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2011.08.049"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1055\/s\u20100042\u2010106958"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2017.07.010"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics14040427"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.igie.2025.01.009"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/dc.23870"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pan.2020.12.015"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1177\/2050640618804443"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dld.2019.03.025"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.giec.2013.08.003"},{"key":"e_1_2_8_27_1","first-page":"209","volume-title":"WHO Classification of Tumours of Endocrine Organs","author":"Lloyd R. 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