{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T00:11:58Z","timestamp":1789171918451,"version":"build-2803163510"},"reference-count":14,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,8,24]],"date-time":"2025-08-24T00:00:00Z","timestamp":1755993600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2025,8,24]],"date-time":"2025-08-24T00:00:00Z","timestamp":1755993600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diagnostic Cytopathology"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Endobronchial ultrasound (EBUS) guided fine needle aspiration is a modality for diagnosing lung nodules as well as fungal organisms. One of the most frequently isolated fungal organisms from immunocompromised patients or immunocompetent patients with severe COPD is\n                    <jats:italic>Aspergillus<\/jats:italic>\n                    spp.\n                    <jats:italic>,<\/jats:italic>\n                    which is characterized by septate hyphae with progressive dichotomous branching. However, this finding is not entirely specific to\n                    <jats:italic>Aspergillus<\/jats:italic>\n                    spp. since it can be seen in non\u2010Aspergillus fungi. Nonetheless, the presence of fruiting bodies, background inflammation, and in correlation with the clinical and radiologic findings are supportive of\n                    <jats:italic>Aspergillus<\/jats:italic>\n                    infection. This case report describes a 73\u2010year\u2010old male smoker with severe COPD who presented with multiple lung nodules and hilar lymphadenopathy. An EBUS guided fine needle aspiration of the largest left lung cavitary nodule showed the presence of uniformly sized, septate hyphae with progressive dichotomous branching. There were randomly distributed fruiting bodies composed of a smooth stalk, a swollen vesicle at the terminal end of the stalk, and a single row of phialides occupying the upper two\u2010thirds of the vesicle. The background showed marked acute inflammation and singly dispersed conidia (spores). The GMS stain highlighted the presence of fruiting bodies, dichotomous branching septate hyphae, and singly dispersed conidia. The Fungal PCR result confirmed the presence of\n                    <jats:italic>Aspergillus fumigatus<\/jats:italic>\n                    . Hence, the presence of fruiting bodies is extremely helpful in the identification of the\n                    <jats:italic>Aspergillus<\/jats:italic>\n                    spp. over the other non\u2010Aspergillus fungi. While species identification is often performed in culture, the cytomorphology of the fruiting body could favor\n                    <jats:italic>Aspergillus<\/jats:italic>\n                    spp., which could facilitate prompt medical management.\n                  <\/jats:p>","DOI":"10.1002\/dc.70014","type":"journal-article","created":{"date-parts":[[2025,8,25]],"date-time":"2025-08-25T06:47:05Z","timestamp":1756104425000},"page":"576-579","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Fruiting Bodies of\n                    <i>Aspergillus<\/i>\n                    in a Cavitary Lung Mass: A Rare Finding on Fine Needle Aspiration"],"prefix":"10.1002","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0375-1964","authenticated-orcid":false,"given":"Maria Luisa C.","family":"Policarpio\u2010Nicolas","sequence":"first","affiliation":[{"name":"Department of Pathology Cleveland Clinic  Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacob","family":"Rattin","sequence":"additional","affiliation":[{"name":"Department of Pathology Cleveland Clinic  Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanjay","family":"Mukhopadhyay","sequence":"additional","affiliation":[{"name":"Department of Pathology Cleveland Clinic  Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,8,24]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2022.888452"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.4103\/0970\u20102113.120623"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/dc.23231"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1159\/000325131"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/dc.20267"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/dc.23658"},{"issue":"2","key":"e_1_2_6_8_1","first-page":"269","article-title":"Fungal Fruiting Heads in Papanicolaou Smears as Evidence of Spatula Contamination","volume":"36","author":"Rupp M.","year":"1992","journal-title":"Acta Cytologica"},{"key":"e_1_2_6_9_1","volume-title":"Nova Plantarum Genera Juxta Tournefortii Methodum Disposita","author":"Micheli P. A.","year":"1729"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2016.00043"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-323-44585-6.00008-4"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/dc.2027"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-323-44585-6.00008-4"},{"key":"e_1_2_6_14_1","first-page":"7","volume-title":"Aspergillosis: From Diagnosis to Prevention","author":"Guarro J.","year":"2010"},{"issue":"1","key":"e_1_2_6_15_1","first-page":"112","article-title":"Fungal Fruiting Bodies in a Pap Smear: Contamination or Infection?","volume":"50","author":"Riben M.","year":"2006","journal-title":"Acta Cytologica"}],"container-title":["Diagnostic Cytopathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/dc.70014","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/dc.70014","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/dc.70014","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T23:30:32Z","timestamp":1789169432000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/dc.70014"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,24]]},"references-count":14,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2025,11]]}},"alternative-id":["10.1002\/dc.70014"],"URL":"https:\/\/doi.org\/10.1002\/dc.70014","archive":["Portico"],"relation":{},"ISSN":["8755-1039","1097-0339"],"issn-type":[{"value":"8755-1039","type":"print"},{"value":"1097-0339","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,24]]},"assertion":[{"value":"2025-07-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-08-18","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-08-24","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}