{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T04:36:28Z","timestamp":1792470988958,"version":"4.5.0"},"reference-count":9,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,9,13]],"date-time":"2025-09-13T00:00:00Z","timestamp":1757721600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diagnostic Cytopathology"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Head and neck squamous cell carcinoma (HNSCC) frequently metastasizes to the cervical lymph nodes and is subjected to fine needle aspiration biopsy cytology (FNABC). The aim of this study was to describe the cytomorphological spectrum and explore the association with the primary site of origin and the short\u2010term outcome following radiation therapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A retrospective cytomorphological evaluation was performed on 338 cases of metastatic squamous cell carcinoma to cervical lymph nodes from HNSCC primaries. The clinical details including the age, sex, primary site of origin confirmed on histopathology, composite stage, and outcome at 1\u2010year follow\u2010up (86) were obtained from the records. An exploratory analysis was performed to derive any association of the cytomorphological features with the primary site of origin and short\u2010term outcome.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The patients' age ranged from 28 to 89\u2009years (mean, 56.6\u2009years) with marked male preponderance, and the majority in Stage IV. The primary site was the oral cavity (45.2%) followed by the oropharynx (37%), hypopharynx (8.5%), nasopharynx (6.2%) and larynx (3.1%). Cytomorphology revealed keratinization of any degree in 86% of cases. The background was necroinflammatory, fluidy, or reactive lymphocytic with granulomatous reaction in 5% of cases. The chromatin pattern (vesicular, coarse or dense hyperchromatic), presence of nucleoli, and reactive lymphocytic background showed site\u2010specific differences. However, no cytomorphological parameter showed any association with short\u2010term outcome.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Metastatic HNSCC to the cervical lymph nodes presents a broad cytomorphological spectrum with no specific association with outcome.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/dc.70019","type":"journal-article","created":{"date-parts":[[2025,9,13]],"date-time":"2025-09-13T10:04:42Z","timestamp":1757757882000},"page":"604-612","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Metastatic Head and Neck Squamous Cell Carcinoma: Cytomorphological Spectrum on Fine Needle Aspiration Biopsy Cytology and Its Relevance"],"prefix":"10.1002","volume":"53","author":[{"given":"Dipanwita","family":"Biswas","sequence":"first","affiliation":[{"name":"Department of Cytology &amp; Gynecological Pathology Postgraduate Institute of Medical Education and Research  Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aadya","family":"Kerkar","sequence":"additional","affiliation":[{"name":"Department of Cytology &amp; Gynecological Pathology Postgraduate Institute of Medical Education and Research  Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nuli Muni","family":"Kiran","sequence":"additional","affiliation":[{"name":"Department of Radiotherapy and Oncology Postgraduate Institute of Medical Education and Research  Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sushmita","family":"Ghoshal","sequence":"additional","affiliation":[{"name":"Department of Radiotherapy and Oncology Postgraduate Institute of Medical Education and Research  Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5520-8306","authenticated-orcid":false,"given":"Suvradeep","family":"Mitra","sequence":"additional","affiliation":[{"name":"Department of Histopathology Postgraduate Institute of Medical Education and Research  Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nalini","family":"Gupta","sequence":"additional","affiliation":[{"name":"Department of Cytology &amp; Gynecological Pathology Postgraduate Institute of Medical Education and Research  Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanjit","family":"Bal","sequence":"additional","affiliation":[{"name":"Department of Histopathology Postgraduate Institute of Medical Education and Research  Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1771-091X","authenticated-orcid":false,"given":"Radhika","family":"Srinivasan","sequence":"additional","affiliation":[{"name":"Department of Cytology &amp; Gynecological Pathology Postgraduate Institute of Medical Education and Research  Chandigarh India"},{"name":"Department of Histopathology Postgraduate Institute of Medical Education and Research  Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,9,13]]},"reference":[{"key":"e_1_2_8_2_1","unstructured":"World Health Organization \u201cGLOBOCAN 2020 Age Standardized (World) Incidence and Mortality Rates Lips Oral Cavity \u201d2020 https:\/\/gco.iarc.fr\/today\/data\/factsheets\/cancers\/1\u2010Lip\u2010oral\u2010cavity\u2010fact\u2010sheet.pdf."},{"key":"e_1_2_8_3_1","unstructured":"World Health Organization \u201cGLOBOCAN 2020 Age Standardized (World) Incidence and Mortality Rates Oropharynx \u201d2020 https:\/\/gco.iarc.fr\/today\/data\/factsheets\/cancers\/3\u2010Oropharynx\u2010fact\u2010sheet.pdf."},{"key":"e_1_2_8_4_1","unstructured":"World Health Organization \u201cGLOBOCAN 2020 Age Standardized (World) Incidence and Mortality Rates Hypopharynx \u201d2020 https:\/\/gco.iarc.fr\/today\/data\/factsheets\/cancers\/5\u2010Hypopharynx\u2010fact\u2010sheet.pdf."},{"key":"e_1_2_8_5_1","unstructured":"India Source \u201cGLOBOCAN 2020 Age Standardized (World) Incidence Mortality Rates and Prevalence by Cancer Site \u201d2021 https:\/\/gco.iarc.fr\/today\/data\/factsheets\/populations\/356\u2010india\u2010fact\u2010sheets.pdf."},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.31557\/APJCP.2019.20.11.3269"},{"key":"e_1_2_8_7_1","first-page":"258","article-title":"Cytodiagnosis of Squamous Cell Carcinoma. Malignant Squamous Cell Cytology","volume":"5","author":"Gupta P. K.","year":"1968","journal-title":"Indian Journal of Cancer"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1983.00800250029007"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0339(199809)19:3<168::AID-DC2>3.0.CO;2-9"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjoms.2022.07.009"}],"container-title":["Diagnostic Cytopathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/dc.70019","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T08:56:34Z","timestamp":1761987394000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/dc.70019"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,13]]},"references-count":9,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["10.1002\/dc.70019"],"URL":"https:\/\/doi.org\/10.1002\/dc.70019","archive":["Portico"],"relation":{},"ISSN":["8755-1039","1097-0339"],"issn-type":[{"value":"8755-1039","type":"print"},{"value":"1097-0339","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,9,13]]},"assertion":[{"value":"2025-04-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-09-06","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-09-13","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}