{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T18:09:20Z","timestamp":1793729360022,"version":"4.6.1"},"reference-count":42,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,9,19]],"date-time":"2025-09-19T00:00:00Z","timestamp":1758240000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diagnostic Cytopathology"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Imaging\u2010driven detection of thyroid nodules has expanded the role of fine\u2010needle aspiration (FNA) while demanding integration of molecular data into routine cytologic assessment. We present four illustrative cases spanning the contemporary diagnostic spectrum: (1) an Atypia of Undetermined Significance (AUS) nodule with dual low\u2010level\n                    <jats:italic>PTEN<\/jats:italic>\n                    mutations managed by active surveillance; (2) an oncocytic follicular neoplasm upgraded to total thyroidectomy by concurrent\n                    <jats:italic>HRAS<\/jats:italic>\n                    and\n                    <jats:italic>TERT<\/jats:italic>\n                    promoter mutations; (3) an oncocytic subtype poorly differentiated thyroid carcinoma (O\u2010PDTC) highlighting subtle high\u2010grade cytologic cues and a distinct genomic profile; and (4) a pediatric poorly differentiated carcinoma harboring a\n                    <jats:italic>DICER1<\/jats:italic>\n                    hotspot mutation, underscoring age\u2010specific biology and the need for genetic consideration. These cases emphasize that morphology remains foundational, but mutation context, single versus co\u2010alterations, allelic burden, and patient age ultimately direct management. Harmonized reporting that clearly conveys molecular findings is essential to translate limited cytology material into precise, patient\u2010specific care.\n                  <\/jats:p>","DOI":"10.1002\/dc.70022","type":"journal-article","created":{"date-parts":[[2025,9,19]],"date-time":"2025-09-19T10:06:54Z","timestamp":1758276414000},"page":"597-603","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Diagnosing Thyroid Lesions Through A Morphology\u2013Molecular Lens: Four Case\u2010Based Lessons From 22nd International Congress of Cytology\u2014Florence 2025"],"prefix":"10.1002","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3736-1323","authenticated-orcid":false,"given":"Sule","family":"Canberk","sequence":"first","affiliation":[{"name":"RISE\u2010Health, Department of Pathology, Faculty of Medicine University of Porto, Alameda Professor Hern\u00e2ni Monteiro  Porto Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3280-0534","authenticated-orcid":false,"given":"N. Paul","family":"Ohori","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Pittsburgh and UPMC\u2010Presbyterian  Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rita","family":"Luis","sequence":"additional","affiliation":[{"name":"Department of Pathology Unidade Local de Sa\u00fade S\u00e3o Jos\u00e9  Lisbon Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Vigliar","sequence":"additional","affiliation":[{"name":"Department of Public Health University of Naples Federico II  Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vivian","family":"Weiss","sequence":"additional","affiliation":[{"name":"Department of Pathology, Microbiology, and Immunology Vanderbilt University Medical Center  Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9342-3069","authenticated-orcid":false,"given":"Zubair","family":"Baloch","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine University of Pennsylvania  Philadelphia Pennsylvania 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