{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T14:20:15Z","timestamp":1787062815678,"version":"build-2736575974"},"reference-count":9,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T00:00:00Z","timestamp":1761696000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T00:00:00Z","timestamp":1761696000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diagnostic Cytopathology"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    <jats:italic>CIC<\/jats:italic>\n                    \u2010rearranged sarcomas (CDS) are rare, aggressive undifferentiated small round cell tumors recently classified as a distinct entity by the World Health Organization. These tumors are defined by\n                    <jats:italic>CIC<\/jats:italic>\n                    gene fusions, most commonly\n                    <jats:italic>CIC::DUX4<\/jats:italic>\n                    , and are associated with poor prognoses and diagnostic challenges, particularly in limited cytological samples. We report the case of a 37\u2010year\u2010old male who presented with respiratory symptoms and was found to have mediastinal lymphadenopathy. Fine\u2010needle aspiration (FNA) of a right paratracheal lymph node revealed hypercellular smears of dyscohesive tumor cells with high nuclear\u2010to\u2010cytoplasmic ratios, prominent nucleoli, and cytoplasmic vacuoles. Immunohistochemistry showed positivity for WT1, CD99, and vimentin, while RNA sequencing confirmed a\n                    <jats:italic>CIC::DUX4<\/jats:italic>\n                    fusion, establishing the diagnosis of CDS. This case highlights the critical role of integrating cytopathology, immunohistochemistry, and molecular diagnostics in identifying CDS, particularly in atypical anatomical sites. Early and accurate diagnosis is essential for guiding clinical management in this rare and aggressive sarcoma subtype.\n                  <\/jats:p>","DOI":"10.1002\/dc.70038","type":"journal-article","created":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T08:58:42Z","timestamp":1761728322000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["A Rare Case of\n                    <i>CIC\u2010DUX4<\/i>\n                    Sarcoma in a Mediastinal Lymph Node Diagnosed by Fine Needle Aspiration Cytology"],"prefix":"10.1002","volume":"54","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0408-8436","authenticated-orcid":false,"given":"Fnu","family":"Mahjabin","sequence":"first","affiliation":[{"name":"Department of Pathology, Immunology and Laboratory Medicine, College of Medicine University of Florida  Gainesville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tara J.","family":"Hajarat","sequence":"additional","affiliation":[{"name":"Department of Pathology, Immunology and Laboratory Medicine, College of Medicine University of Florida  Gainesville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra","family":"De Leo","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, College of Medicine University of Florida  Gainesville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elham","family":"Nasri","sequence":"additional","affiliation":[{"name":"Department of Pathology, Immunology and Laboratory Medicine, College of Medicine University of Florida  Gainesville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine A.","family":"Gonsalves","sequence":"additional","affiliation":[{"name":"Department of Pathology, Immunology and Laboratory Medicine, College of Medicine University of Florida  Gainesville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,10,29]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.32074\/1591\u2010951x\u2010784"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2022.1018992"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2014.83"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/cup.14748"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/dc.24027"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncy.21685"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pathol.2019.09.015"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/his.15341"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.5858\/arpa.2024\u20100407\u2010OA"}],"container-title":["Diagnostic Cytopathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/dc.70038","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/dc.70038","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/dc.70038","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T09:01:18Z","timestamp":1772960478000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/dc.70038"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,29]]},"references-count":9,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1002\/dc.70038"],"URL":"https:\/\/doi.org\/10.1002\/dc.70038","archive":["Portico"],"relation":{},"ISSN":["8755-1039","1097-0339"],"issn-type":[{"value":"8755-1039","type":"print"},{"value":"1097-0339","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,29]]},"assertion":[{"value":"2025-03-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-10-08","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-10-29","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}