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Intrathyroidal localization is exceedingly rare and may mimic malignancy both radiologically and cytologically\u2014particularly when squamous cells are identified and misinterpreted as malignant. Surgical resection is often required to achieve a definitive diagnosis. Our report highlights the diagnostic challenges of such lesions and underscores the importance of integrating clinical, cytological, and imaging data.<\/jats:p>","DOI":"10.1002\/dc.70047","type":"journal-article","created":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T07:12:54Z","timestamp":1762931574000},"page":"63-66","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Intrathyroidal Branchial Cleft Cyst Mimicking Malignancy: A Cytologic Pitfall in the Era of Incidental Imaging"],"prefix":"10.1002","volume":"54","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0230-0974","authenticated-orcid":false,"given":"Luca","family":"Giovanella","sequence":"first","affiliation":[{"name":"Department of Nuclear Medicine and Thyroid Center Gruppo Ospedaliero Moncucco, Clinica Moncucco  Lugano Switzerland"},{"name":"Clinic for Nuclear Medicine University Hospital of Z\u00fcrich  Z\u00fcrich 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