{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T23:48:52Z","timestamp":1787960932623,"version":"build-2784847793"},"reference-count":17,"publisher":"Wiley","license":[{"start":{"date-parts":[[2025,11,24]],"date-time":"2025-11-24T00:00:00Z","timestamp":1763942400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diagnostic Cytopathology"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>NUT carcinoma (NC) is a rare and highly aggressive type of poorly differentiated carcinoma that originates from undefined anatomical sites, primarily in midline structures of the upper respiratory tract. We report the case of a male patient in his fifth decade of life who is a non\u2010smoker. He presented with symptoms of dyspnea and cough, and had previously been treated for an atypical infectious process. A PET scan revealed a right pulmonary hilar mass alongside pathological lymphadenopathy. An endobronchial ultrasound\u2010guided fine needle aspiration (EBUS\u2010FNA) of the subcarinal lymph node was performed, followed by a cytomorphological evaluation in\u00a0situ (Rapid On\u2010Site Evaluation\u2014ROSE) for sample management. The smear showed high hypercellularity with loosely cohesive cells arranged mostly in a single\u2010cell pattern, exhibiting a poorly differentiated appearance. Immunohistochemical studies on the cell block indicated nuclear positivity for NUT expression, confirming the diagnosis of pulmonary NC. Poorly differentiated high\u2010grade neoplasms in middle\u2010aged patients present a significant challenge when the tumor sample is limited. The cytopathologist's role is to optimize the available material for a complete and accurate diagnosis, which is essential for appropriate treatment.<\/jats:p>","DOI":"10.1002\/dc.70054","type":"journal-article","created":{"date-parts":[[2025,11,24]],"date-time":"2025-11-24T11:06:30Z","timestamp":1763982390000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["A Case Report of Undifferentiated\n                    <scp>NUT<\/scp>\n                    Carcinoma of Lung Diagnosed by\n                    <scp>EBUS<\/scp>\n                    \u2010\n                    <scp>FNA<\/scp>\n                    : If You Hear Hoofbeats Do Not Assume They Are Horses"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0559-5296","authenticated-orcid":false,"given":"Tania","family":"Labiano","sequence":"first","affiliation":[{"name":"Department of Pathology Universitary Hospital of Navarra  Pamplona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mart\u00edn","family":"Fuentes","sequence":"additional","affiliation":[{"name":"Department of Pathology Hospital Civil de Culiac\u00e1n  Sinaloa M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yessica","family":"Rodriguez","sequence":"additional","affiliation":[{"name":"Department of Pathology Universitary Hospital of Navarra  Pamplona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Antonio","family":"Cascante Rodrigo","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Medicine Hospital Universitario de Navarra  Pamplona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6796-9380","authenticated-orcid":false,"given":"Mar\u00eda D.","family":"Lozano","sequence":"additional","affiliation":[{"name":"Department of Pathology University Clinic of Navarra  Pamplona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teresa","family":"Dot","sequence":"additional","affiliation":[{"name":"Department of Pathology Universitary Hospital of Navarra  Pamplona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hugo","family":"Arasanz","sequence":"additional","affiliation":[{"name":"Department of Oncology Hospital Universitario de Navarra  Pamplona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Jos\u00e9","family":"Garc\u00eda\u2010Velloso","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine University Clinic of Navarra  Pamplona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Almud\u00e9var","sequence":"additional","affiliation":[{"name":"Department of Pathology Universitary Hospital of Navarra  Pamplona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,11,24]]},"reference":[{"key":"e_1_2_9_2_1","first-page":"364","volume-title":"WHO Classification of Tumours Thoracic Tumours","author":"French C. A.","year":"2021"},{"issue":"11","key":"e_1_2_9_3_1","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1111\/pin.12727","article-title":"NUT Carcinoma: Clinicopathologic Features, Pathogenesis, and Treatment","volume":"68","author":"French C. A.","year":"2018","journal-title":"Pathology International"},{"key":"e_1_2_9_4_1","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1146\/annurev-pathol-011811-132438","article-title":"Pathogenesis of NUT Midline Carcinoma","volume":"7","author":"French C. A.","year":"2012","journal-title":"Annual Review of Pathology"},{"issue":"7","key":"e_1_2_9_5_1","doi-asserted-by":"crossref","first-page":"984","DOI":"10.1097\/PAS.0b013e318198d666","article-title":"Diagnosis of NUT Midline Carcinoma Using a NUT\u2010Specific Monoclonal Antibody","volume":"33","author":"Haack H.","year":"2009","journal-title":"American Journal of Surgical Pathology"},{"key":"e_1_2_9_6_1","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2022.914031","article-title":"NUT Carcinoma\u2010An Underdiagnosed Malignancy","volume":"12","author":"Lauer U. M.","year":"2022","journal-title":"Frontiers in Oncology"},{"key":"e_1_2_9_7_1","unstructured":"BlueBooksOnline \u201ccitado 1 de agosto de 2024 \u201dhttps:\/\/tumourclassification.iarc.who.int\/chaptercontent\/35\/243."},{"issue":"8","key":"e_1_2_9_8_1","doi-asserted-by":"crossref","first-page":"1222","DOI":"10.1097\/PAS.0b013e318258f03b","article-title":"Pathologic Characteristics of NUT Midline Carcinoma Arising in the Mediastinum","volume":"36","author":"Evans A. 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A.","year":"2016","journal-title":"Cancer Cytopathology"},{"issue":"1","key":"e_1_2_9_13_1","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1007\/s12105-013-0428-1","article-title":"The Importance of Diagnosing NUT Midline Carcinoma","volume":"7","author":"French C. A.","year":"2013","journal-title":"Head and Neck Pathology"},{"issue":"10","key":"e_1_2_9_14_1","doi-asserted-by":"crossref","first-page":"e176","DOI":"10.1016\/j.jtho.2020.07.017","article-title":"The Isoform Matters in NUT Carcinoma: A Diagnostic Pitfall of p40 Immunohistochemistry","volume":"15","author":"Matsuda K.","year":"2020","journal-title":"Journal of Thoracic Oncology: Official Publication of the International Association for the Study of Lung Cancer"},{"issue":"3","key":"e_1_2_9_15_1","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1097\/PAS.0b013e31824230a8","article-title":"NUT Midline Carcinoma: Report of 2 Cases Suggestive of Pulmonary Origin","volume":"36","author":"Tanaka M.","year":"2012","journal-title":"American Journal of Surgical Pathology"},{"issue":"3","key":"e_1_2_9_16_1","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1097\/01.pai.0000142160.52670.ce","article-title":"Expression of p63 in Diffuse Large B\u2010Cell Lymphoma","volume":"13","author":"Hedvat C. V.","year":"2005","journal-title":"Applied Immunohistochemistry & Molecular Morphology"},{"issue":"10","key":"e_1_2_9_17_1","doi-asserted-by":"crossref","first-page":"6807","DOI":"10.3390\/curroncol29100536","article-title":"Diagnosis, Treatment and Prognosis of Primary Pulmonary NUT Carcinoma: A Literature Review","volume":"29","author":"Yuan J.","year":"2022","journal-title":"Current Oncology"},{"issue":"7327","key":"e_1_2_9_18_1","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1038\/nature09504","article-title":"Selective Inhibition of BET Bromodomains","volume":"468","author":"Filippakopoulos P.","year":"2010","journal-title":"Nature"}],"container-title":["Diagnostic Cytopathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/dc.70054","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,24]],"date-time":"2025-11-24T11:06:34Z","timestamp":1763982394000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/dc.70054"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,24]]},"references-count":17,"alternative-id":["10.1002\/dc.70054"],"URL":"https:\/\/doi.org\/10.1002\/dc.70054","archive":["Portico"],"relation":{},"ISSN":["8755-1039","1097-0339"],"issn-type":[{"value":"8755-1039","type":"print"},{"value":"1097-0339","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,24]]},"assertion":[{"value":"2025-02-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-02","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-24","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"dc.70054"}}