{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T10:34:03Z","timestamp":1770892443190,"version":"3.50.1"},"reference-count":20,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,12,8]],"date-time":"2025-12-08T00:00:00Z","timestamp":1765152000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,12,8]],"date-time":"2025-12-08T00:00:00Z","timestamp":1765152000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diagnostic Cytopathology"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Granular cell tumor (GCT) is a rare mesenchymal neoplasm that is believed to originate from Schwann\u2010like mesenchymal cells. It affects more women than men with an F:M ratio of 5:4 and can involve various body sites such as peripheral soft tissues, trunk, and head and neck. Multiple lesions can be seen in up to 15% patients. Most of GCT are benign with indolent behavior. Rare cases show cytological atypia and considered histologically malignant; or show metastasis and considered clinically malignant. Endoscopic ultrasound\u2010guided fine needle aspiration (EUS\u2010FNA) is widely used nowadays for the diagnosis of epithelial malignancies of the gastrointestinal tract and pancreatobiliary tract. Its efficacy for submucosal and intramural mesenchymal lesions is focused primarily on gastrointestinal stromal tumors (GIST) because of their higher incidence compared with other mesenchymal lesions. Biliary tract GCT is rarely reported in the literature. Preoperative diagnosis of GCT has important therapeutic and prognostic value. Formulating such a diagnosis using cytologic smears alone is extremely challenging, but a definitive and accurate diagnosis is possible when cytomorphology is coupled with optimal cellularity and immunohistochemistry studies on the concurrent cellblock or tissue biopsy. Here we report the first case of biliary GCT diagnosed by EUS\u2010FNA cytology and concurrent biopsy without surgical resection, which endorses the clinical utility of EUS\u2010FNA cytology on evaluating biliary lesions and broaden our differential diagnosis of biliary neoplasms.<\/jats:p>","DOI":"10.1002\/dc.70062","type":"journal-article","created":{"date-parts":[[2025,12,8]],"date-time":"2025-12-08T09:05:22Z","timestamp":1765184722000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Granular Cell Tumor of the Bile Duct: A Challenging Cytologic Diagnosis on Endoscopic Ultrasound\u2010Guided Fine Needle Aspiration"],"prefix":"10.1002","volume":"54","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6022-7317","authenticated-orcid":false,"given":"Ujalla","family":"Sheikh","sequence":"first","affiliation":[{"name":"Department of Pathology Rush University Medical Center  Chicago Illinois USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7385-1242","authenticated-orcid":false,"given":"Lei","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Pathology Rush University Medical Center  Chicago Illinois USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paolo","family":"Gattuso","sequence":"additional","affiliation":[{"name":"Department of Pathology Rush University Medical Center  Chicago Illinois USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3248-093X","authenticated-orcid":false,"given":"Lin","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Pathology Rush University Medical Center  Chicago Illinois USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,12,8]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097\u20100142(196209\/10)15:5<936::aid\u2010cncr2820150509>3.0.co;2\u2010f"},{"key":"e_1_2_8_3_1","unstructured":"F.ObeidinandB.Alexiev Granular Cell Tumor. PathologyOutlines.com websiteaccessed May 22 2024 https:\/\/www.pathologyoutlines.com\/topic\/softtissuegranularcell.html."},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478\u2010199807000\u201000001"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/9576487"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jasc.2020.05.009"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1159\/000018858"},{"issue":"4","key":"e_1_2_8_8_1","first-page":"398","article-title":"Granular\u2010Cell Myoblastoma of Common Bile Duct; Report of a Case With Autopsy Findings","volume":"54","author":"Coggins R. P.","year":"1952","journal-title":"AMA Archives of Pathology"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.20524\/aog.2018.0275"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v18.i43.6324"},{"key":"e_1_2_8_11_1","first-page":"435","volume-title":"5\u2010Gastrointestinal and Liver Pathology: Foundations in Diagnostic Pathology","author":"Conner J.","year":"2020"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.14309\/crj.0000000000000193"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1159\/000326134"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nmni.2018.10.001"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijscr.2022.106921"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40792\u2010020\u201000899\u20106"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2021.701400"},{"issue":"3","key":"e_1_2_8_18_1","first-page":"247","article-title":"Granular Cell Tumour of the Bile Duct Mimicking Distal Cholangio\u2010Carcinoma: One Case Report and Review of the Literature","volume":"61","author":"Tonsi A.","year":"2006","journal-title":"Minerva Chirurgica"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diii.2012.10.019"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007890\u2010199907270\u201000030"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e3181e5af9d"}],"container-title":["Diagnostic Cytopathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/dc.70062","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/dc.70062","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/dc.70062","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T09:43:26Z","timestamp":1770889406000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/dc.70062"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,8]]},"references-count":20,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,3]]}},"alternative-id":["10.1002\/dc.70062"],"URL":"https:\/\/doi.org\/10.1002\/dc.70062","archive":["Portico"],"relation":{},"ISSN":["8755-1039","1097-0339"],"issn-type":[{"value":"8755-1039","type":"print"},{"value":"1097-0339","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,8]]},"assertion":[{"value":"2025-06-04","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-09-13","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-08","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}