{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T15:07:26Z","timestamp":1780412846948,"version":"3.54.1"},"reference-count":16,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,12,29]],"date-time":"2025-12-29T00:00:00Z","timestamp":1766966400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,12,29]],"date-time":"2025-12-29T00:00:00Z","timestamp":1766966400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diagnostic Cytopathology"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Malignant mesothelioma (MM) is a rare yet aggressive neoplasm that arises from mesothelial cells lining the thoracic and abdominal cavities, the pericardium, and the tunica testis. Characterized by rapid progression, high invasiveness, and a poor prognosis, MM poses significant clinical challenges. SMARCB1, also referred to as INI\u20101, hSNF5, or BAF47, is located on chromosome 22q11.2 and serves as a critical subunit of the SWI\/SNF chromatin remodeling complex. INI\u20101 functions as a tumor suppressor and plays a vital role in DNA damage repair and regulation of cell growth. Case Presentation: A 37\u2010year\u2010old Chinese male with no history of asbestos exposure but a 10\u2010year smoking history (30 cigarettes per day) presented with a cough lasting one month and a fever persisting for one day. Computed tomography (CT) showed multiple enlarged supraclavicular lymph nodes measuring up to 30\u2009\u00d7\u200915\u2009mm bilaterally. An ultrasound\u2010guided fine\u2010needle aspiration (FNA) of the left supraclavicular lymph nodes was subsequently performed. The SurePath\u2010prepared liquid\u2010based cytopathology (LBC) using Papanicolaou\u2010staining revealed tumor cells organized in clusters with indistinct borders. The cells exhibited abundant cytoplasm and pleomorphic round nuclei, which displayed prominent nucleoli and mitotic activity. Additionally, scattered lymphoid fragments were observed in the background. The FNA sample was formalin\u2010fixed and paraffin\u2010embedded for cell block; 4\u2010\u03bcm thick sections were prepared. Histological examination using HE\u2010stained cell block revealed a solid sheet\u2010like tumor growth characterized by minimal stroma and the absence of fibrovascular cores. The neoplastic cells had well\u2010defined borders, abundant eosinophilic (partially clear) cytoplasm, and round\u2010to\u2010oval nuclei displaying focal atypia, finely dispersed chromatin, and prominent nucleoli. Immunohistochemistry (IHC) demonstrated positive staining for CK(pan), calretinin, D2\u201040, and SMARCA4, whereas NapsinA, TTF\u20101, P40, NUT, and WT\u20101 yielded negative results. The confirmed loss of INI\u20101 expression ultimately led to the diagnosis of metastatic INI\u20101 deficient MM. Conclusion: This case highlights the cytomorphological features and immunophenotype of INI\u20101 deficient MM diagnosed through FNA. An accurate diagnosis requires a thorough clinicopathological correlation and a comprehensive IHC panel.<\/jats:p>","DOI":"10.1002\/dc.70073","type":"journal-article","created":{"date-parts":[[2025,12,29]],"date-time":"2025-12-29T08:50:41Z","timestamp":1766998241000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Cytopathologic Features of Metastatic Malignant Mesothelioma With\n                    <scp>SMARCB1<\/scp>\n                    (\n                    <scp>INI<\/scp>\n                    \u20101) Deficient Diagnosed by Ultrasound\u2010Guided Fine\u2010Needle Aspiration: A Case Report"],"prefix":"10.1002","volume":"54","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2921-7372","authenticated-orcid":false,"given":"Jun","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Cytopathology Ningbo Clinical Pathology Diagnosis Center  Zhejiang China"},{"name":"Department of Pathology Ningbo Medical Center Lihuili Hospital  Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juandi","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Cytopathology Ningbo Clinical Pathology Diagnosis Center  Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Jin","sequence":"additional","affiliation":[{"name":"Department of Experimental Pathology Ningbo Clinical Pathology Diagnosis Center  Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deng","family":"Pan","sequence":"additional","affiliation":[{"name":"Department of Cytopathology Ningbo Clinical Pathology Diagnosis Center  Zhejiang China"},{"name":"Department of Pathology Ningbo Medical Center Lihuili Hospital  Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Shao","sequence":"additional","affiliation":[{"name":"Department of Cytopathology Ningbo Clinical Pathology Diagnosis Center  Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,12,29]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1912719"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21660"},{"issue":"6","key":"e_1_2_11_4_1","doi-asserted-by":"crossref","DOI":"10.36416\/1806-3756\/e20210129","article-title":"Malignant Pleural Mesothelioma: An Update","volume":"47","author":"Hajj G. 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M.","year":"2021","journal-title":"Jornal Brasileiro de Pneumologia"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41571-020-0357-3"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e31822b325b"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/cas.13173"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/28212"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000000236"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000000285"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.6278"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gore.2023.101294"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.30038"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12105-021-01338-0"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41379-022-01133-4"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/pin.12623"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2019.08.016"}],"container-title":["Diagnostic Cytopathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/dc.70073","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/dc.70073","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/dc.70073","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T08:27:13Z","timestamp":1772958433000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/dc.70073"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,29]]},"references-count":16,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,4]]}},"alternative-id":["10.1002\/dc.70073"],"URL":"https:\/\/doi.org\/10.1002\/dc.70073","archive":["Portico"],"relation":{},"ISSN":["8755-1039","1097-0339"],"issn-type":[{"value":"8755-1039","type":"print"},{"value":"1097-0339","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,29]]},"assertion":[{"value":"2025-07-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-15","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-29","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}