{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T14:54:54Z","timestamp":1772981694375,"version":"3.50.1"},"reference-count":23,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T00:00:00Z","timestamp":1767657600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T00:00:00Z","timestamp":1767657600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diagnostic Cytopathology"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Lymphadenopathy is the enlargement of lymph nodes that can be caused by various factors, ranging from infectious to malignant. Fine\u2010needle aspiration cytology (FNAC) is a simple, minimally invasive, and cost\u2010effective diagnostic method for lymphadenopathy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study aimed to evaluate the cytopathological patterns and diagnostic accuracy of fine\u2010needle aspiration in patients presenting with lymphadenopathy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A retrospective, hospital\u2010based study was conducted at Hiwot Fana Comprehensive Specialized University Hospital in Eastern Ethiopia, from January 2019 to December 2022. Patients with lymphadenopathy and FNAC were included in this study. Data were collected by extracting information from cytopathology reports. Descriptive statistics were used to describe the independent variables. Bivariable and multivariable logistic regression analyses were performed to identify factors associated with cancerous lymphadenopathy. Sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) were assessed to evaluate the diagnostic accuracy of FNAC.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Result<\/jats:title>\n                    <jats:p>This study included a total of 741 patients with lymph node FNAC. Of those patients, 75.9% were under the age of 30, and 53.4% were male. Cervical lymphadenopathy accounted for 528 (71.3%) of the total lymphadenopathy cases. More than half were diagnosed with tuberculous lymphadenitis (386; 52.1%), followed by reactive lymphadenopathy (226; 30.5%), lymphomas (8.9%), and secondary metastasis (6.7%). The likelihood of malignant lymphadenopathy increased with age, male sex, and involvement of two or more lymph node regions. Lymph node FNAC had an overall diagnostic accuracy of 92.06% with a sensitivity of 86.44%, specificity of 93.78%, PPV of 80.95%, and NPV of 95.77% as compared with lymph node histopathology.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>FNAC remains a simple, valid, reliable, rapid, and cost\u2010effective method for diagnosis, treatment, or indicating further diagnostic work\u2010up in resource\u2010limited countries, such as Ethiopia. FNAC has high diagnostic accuracy, preventing unnecessary surgical removal of lymphadenopathy for diagnosis. However, clinicopathological correlation, repeating the FNAC, or performing an incisional lymph node biopsy is recommended for enhanced efficiency.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/dc.70076","type":"journal-article","created":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T12:09:28Z","timestamp":1767701368000},"page":"270-277","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Role of Fine\u2010Needle Aspiration Cytology in Evaluating Superficial Lymphadenopathy in a Resource\u2010Limited Setting, Eastern Ethiopia"],"prefix":"10.1002","volume":"54","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8219-6259","authenticated-orcid":false,"given":"Addisu","family":"Alemu","sequence":"first","affiliation":[{"name":"Department of Pathology, College of Health and Medical Sciences Haramaya University  Harar Ethiopia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-5586-2964","authenticated-orcid":false,"given":"Biniyam Tedla","family":"Mamo","sequence":"additional","affiliation":[{"name":"Department of Pathology, College of Health and Medical Sciences Haramaya University  Harar Ethiopia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-3864-0685","authenticated-orcid":false,"given":"Mehabuba","family":"Aliyou","sequence":"additional","affiliation":[{"name":"Department of Pathology, College of Health and Medical Sciences Haramaya University  Harar Ethiopia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-1132-4977","authenticated-orcid":false,"given":"Nebil","family":"Fuad","sequence":"additional","affiliation":[{"name":"Department of Radiology Karamara General Hospital  Jijiga Ethiopia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-3117-6233","authenticated-orcid":false,"given":"Yehenaw","family":"Tadele","sequence":"additional","affiliation":[{"name":"Department of Oncology, College of Health and Medical Sciences Haramaya University  Harar Ethiopia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-4606-9925","authenticated-orcid":false,"given":"Abel","family":"Tefera","sequence":"additional","affiliation":[{"name":"Department of Pathology, College of Health and Medical Sciences Haramaya University  Harar Ethiopia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,1,6]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.4103\/2229\u2010516X.205812"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1177\/2050312122113"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-023-43206-7"},{"key":"e_1_2_12_5_1","volume-title":"National Guideline for TB, Leprosy, and DR\u2010TB","author":"Ethiopia Ministry of Health","year":"2018"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jnci.2011.09.009"},{"key":"e_1_2_12_7_1","first-page":"1951","article-title":"Study on the Role of Fine Needle Aspiration Cytology in Cervical Lymphadenopathy","volume":"12","author":"Khan A. H.","year":"2011","journal-title":"World Applied Sciences Journal"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.5455\/2320\u20106012.ijrms20130822"},{"key":"e_1_2_12_9_1","first-page":"10","article-title":"Role of FNAC in Head and Neck Region Lymphadenopathy\u2014A Tertiary Care Centre Experience","volume":"19","author":"Kothari A.","year":"2022","journal-title":"International Archives of Integrated Medicine"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics13040728"},{"key":"e_1_2_12_11_1","volume-title":"WHO Classification of Tumors","author":"WHO Classification of Tumours Editorial Board","year":"2024"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyv284"},{"key":"e_1_2_12_13_1","unstructured":"Ethiopian Public Health Institute Ministry of Health and ICF \u201cEthiopia Service Provision Assessment 2021\u201322 Final Report \u201d2023."},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.18203\/2349-2902.isj20174499"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.21276\/SSR\u2010IIJLS.2019.5.6.4"},{"issue":"3","key":"e_1_2_12_16_1","first-page":"489","article-title":"Role of Fine Needle Aspiration Cytology to Analyze Various Causes of Lymphadenopathy","volume":"4","author":"Patel M. M.","year":"2013","journal-title":"National Journal of Community Medicine"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/tropej\/fmaa040"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.18203\/2320-6012.ijrms20162327"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hemonc.2020.10.002"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1200\/GO.20.00391"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.18231\/2394\u20106792.2017.0018"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncy.22936"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.18203\/2320\u20106012.ijrms20175442"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.3329\/bjmed.v26i2.25448"}],"container-title":["Diagnostic Cytopathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/dc.70076","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/dc.70076","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/dc.70076","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T08:27:20Z","timestamp":1772958440000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/dc.70076"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,6]]},"references-count":23,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,4]]}},"alternative-id":["10.1002\/dc.70076"],"URL":"https:\/\/doi.org\/10.1002\/dc.70076","archive":["Portico"],"relation":{},"ISSN":["8755-1039","1097-0339"],"issn-type":[{"value":"8755-1039","type":"print"},{"value":"1097-0339","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,6]]},"assertion":[{"value":"2025-04-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-30","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-06","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}