{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T22:50:11Z","timestamp":1785451811053,"version":"3.56.0"},"reference-count":19,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T00:00:00Z","timestamp":1769040000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T00:00:00Z","timestamp":1769040000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diagnostic Cytopathology"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The cytological characteristics of high\u2010grade medullary thyroid carcinoma (HG\u2010MTC) remain insufficiently defined. This study aimed to elucidate these features and assess their potential in estimating HG\u2010MTC.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Cytological and histological specimens from 12 patients with HG\u2010MTC and 36 patients with low\u2010grade (LG) MTC were analyzed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Amyloid was observed in 50.0% of LG\u2010MTC nodules but in only 8.3% of HG\u2010MTC nodules (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05). Necrotic materials were observed in only one HG\u2010MTC nodule. The frequencies of intracytoplasmic mucin (25.0%), pseudoinclusions (66.7%), mitotic figures (58.3%), and cannibalism (25.0%) in HG\u2010MTC nodules were significantly higher than those in LG\u2010MTC nodules (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05). Nuclear grooves, fine chromatin pattern, and irregularly shaped nuclei were observed in 41.7%, 41.7%, and 25.0% of HG\u2010MTC nodules, respectively. None of them were observed in LG\u2010MTC nodules (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05). When at least one of the six cytological features including mitotic figures, nuclear grooves, fine chromatin pattern, irregularly shaped nuclei, intracytoplasmic mucin, and cannibalism was present, the sensitivity and specificity for HG\u2010MTC diagnosis were 91.7% and 83.3%, respectively.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Mitotic figures, nuclear grooves, fine chromatin pattern, irregularly shaped nuclei, intracellular mucin, and cannibalism are cytological findings suggestive of HG\u2010MTC. Except for pseudoinclusions, PTC\u2010like nuclear features can be considered important diagnostic clues for HG\u2010MTC.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/dc.70086","type":"journal-article","created":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T08:58:41Z","timestamp":1769072321000},"page":"293-298","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Cytological Features of High\u2010Grade Medullary Thyroid Carcinoma: A Comparative Study With Low\u2010Grade Cases"],"prefix":"10.1002","volume":"54","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9925-9992","authenticated-orcid":false,"given":"Aki","family":"Tanaka","sequence":"first","affiliation":[{"name":"Department of Diagnostic Pathology and Cytology Kuma Hospital  Kobe Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5558-7142","authenticated-orcid":false,"given":"Mitsuyoshi","family":"Hirokawa","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Pathology and Cytology Kuma Hospital  Kobe Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0827-1580","authenticated-orcid":false,"given":"Ayana","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Pathology and Cytology Kuma Hospital  Kobe Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8262-2652","authenticated-orcid":false,"given":"Miyoko","family":"Higuchi","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Pathology and Cytology Kuma Hospital  Kobe Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8365-1372","authenticated-orcid":false,"given":"Risa","family":"Kanematsu","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Pathology and Cytology Kuma Hospital  Kobe Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0999-7420","authenticated-orcid":false,"given":"Naoki","family":"Yamao","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Pathology and Cytology Kuma Hospital  Kobe Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seiji","family":"Kuma","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Pathology and Cytology Kuma Hospital  Kobe Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshitetsu","family":"Hayashi","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Pathology and Cytology Kuma Hospital  Kobe Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0041-197X","authenticated-orcid":false,"given":"Akira","family":"Miyauchi","sequence":"additional","affiliation":[{"name":"Department of Surgery Kuma Hospital  Kobe Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4960-8271","authenticated-orcid":false,"given":"Takashi","family":"Akamizu","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Kuma Hospital  Kobe Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,1,22]]},"reference":[{"key":"e_1_2_11_2_1","first-page":"174","volume-title":"Endocrine and Neuroendocrine Tumours, WHO Classification of Tumours, Volume 10","author":"WHO Classification of Tumours Editorial Board","year":"2025"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncy.22778"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/dc.25243"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-031-28046-7"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1089\/ve.2018.0119"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.21.01329"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anndiagpath.2023.152112"},{"key":"e_1_2_11_9_1","first-page":"241","article-title":"Amyloid Goiter: Cytomorphological Features and Differential Diagnosis on Fine Needle Aspiration Cytology: A Case Report","volume":"36","author":"Ojha S. 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