{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T14:54:45Z","timestamp":1772981685502,"version":"3.50.1"},"reference-count":29,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T00:00:00Z","timestamp":1769990400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T00:00:00Z","timestamp":1769990400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diagnostic Cytopathology"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Atypia of undetermined significance (AUS) represents one of the most controversial diagnostic categories in thyroid cytology, often subject to interpretive bias. This study evaluates whether perceived knowledge of a \u201cpositive molecular test\u201d influences the cytologic interpretation of thyroid fine\u2010needle aspiration (FNA) specimens diagnosed as AUS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Twenty thyroid FNA cases diagnosed as AUS with benign histologic follow\u2010up following thyroidectomy were selected: eight with nuclear atypia (AUS\u2010N), eight with architectural atypia (AUS\u2010A), and four with oncocytic features. Representative slides (Papanicolaou and Diff Quik stained smears) were chosen and participants were instructed to evaluate the cases based on morphologic evaluation. Randomly selected 10 cases in two groups were presented to 10 participants as having \u201cpositive ThyroSeq test\u201d or \u201cno molecular testing information.\u201d No molecular testing was performed in reality, as the aim was to measure the effects of \u201cperceived positive testing.\u201d<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Analysis of 200 responses showed AUS remained the predominant diagnosis (64%) in both groups. When informed of a presumed positive molecular test, participants were more likely to assign a neoplastic or malignant diagnosis (24% vs. 12%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.023). This trend was most pronounced in AUS\u2010N cases (11 vs. 1 reclassified as suspicious\/malignant). For AUS\u2010A cases, more were reclassified as follicular neoplasm under presumed molecular positivity (12 vs. 8). Overall interobserver agreement was poor (Fleiss' kappa\u2009=\u20090.046).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Awareness of a presumed positive molecular test result increases the likelihood of pathologists reclassifying AUS cases as suspicious or malignant. Recognizing and mitigating such cognitive biases is critical for maintaining diagnostic objectivity and ensuring accurate, evidence\u2010based cytologic evaluation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/dc.70092","type":"journal-article","created":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T06:50:44Z","timestamp":1770101444000},"page":"307-314","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Diagnostic Bias in\n                    <scp>AUS<\/scp>\n                    Thyroid Cytology: Role of Perceived Molecular Testing"],"prefix":"10.1002","volume":"54","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2621-339X","authenticated-orcid":false,"given":"Olcay","family":"Kurtulan","sequence":"first","affiliation":[{"name":"Department of Pathology Hacettepe University Faculty of Medicine  Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irem","family":"Kilic","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Loyola University Healthcare System  Maywood Illinois USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hanife","family":"Avc\u0131","sequence":"additional","affiliation":[{"name":"Department of Biostatistics Hacettepe University Faculty of Medicine  Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1825-4637","authenticated-orcid":false,"given":"G\u00fcliz A.","family":"Barkan","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Loyola University Healthcare System  Maywood Illinois USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,2,2]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4684-0201-8"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1309\/AJCPPHLWMI3JV4LA"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-031-28046-7"},{"key":"e_1_2_8_5_1","volume-title":"The Bethesda System for Reporting Thyroid Cytopathology: Definitions, Criteria, and Explanatory Notes","author":"Ali S. 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