{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T04:17:03Z","timestamp":1783743423185,"version":"3.55.0"},"reference-count":14,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T00:00:00Z","timestamp":1769990400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T00:00:00Z","timestamp":1769990400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diagnostic Cytopathology"],"published-print":{"date-parts":[[2026,5]]},"abstract":"ABSTRACT<\/jats:title>\n \n Background<\/jats:title>\n \n Accessory spleens result from failure of splenic fusion during development and are occasionally located in the pancreatic tail, radiographically appearing as solid or solid\/cystic lesions. Fine needle aspiration (\n FNA<\/jats:styled-content>\n ) easily identifies accessory spleens in most samples based on architecture and using\n CD8<\/jats:styled-content>\n to highlight splenic sinusoidal cells. However, in small samples, the architecture is not readily appreciated, and cross\u2010reactivity with\n CD8<\/jats:styled-content>\n + T\u2010cells can create diagnostic challenges. The purpose of the study is to evaluate the utility of steroidogenic factor 1 (\n SF1<\/jats:styled-content>\n ) immunohistochemical (\n IHC<\/jats:styled-content>\n ) staining in identifying accessory spleens.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n A retrospective search of\n FNA<\/jats:styled-content>\n samples from 2010 to 2023 was performed to collect cases signed out as or consistent with intrapancreatic accessory spleen or splenule. Comparison tissue was collected from the regional lymph nodes. Tissues with no or hypocellular cell blocks were excluded from the study.\n IHC<\/jats:styled-content>\n stains\n CD8<\/jats:styled-content>\n and\n SF1<\/jats:styled-content>\n (\n EP434<\/jats:styled-content>\n ) Rabbit Monoclonal Primary Antibody were performed on the cell blocks.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n The intrapancreatic accessory spleens (13 cases) were universally positive for both cytoplasmic\n CD8<\/jats:styled-content>\n and nuclear\n SF1<\/jats:styled-content>\n in a sinusoidal pattern. The regional lymph nodes (15 cases) showed positivity for\n CD8<\/jats:styled-content>\n in background lymphocytes (scattered) and were universally negative for\n SF1.<\/jats:styled-content>\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n While\n CD8<\/jats:styled-content>\n and\n SF1<\/jats:styled-content>\n are comparable in their sensitivity,\n SF1<\/jats:styled-content>\n has benefits in cytologic samples. As a nuclear stain,\n SF1<\/jats:styled-content>\n is more easily interpreted and better suited for cell transfers.\n SF1<\/jats:styled-content>\n also eliminates the background\n CD8<\/jats:styled-content>\n + T cell staining that can be present in lymphoid tissue. Overall, utilization of\n SF1<\/jats:styled-content>\n can be beneficial in the cytologic workup of an intrapancreatic accessory spleen.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/dc.70093","type":"journal-article","created":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T06:48:54Z","timestamp":1770101334000},"page":"327-331","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Steroidogenic Factor 1 (\n SF1<\/scp>\n ) Immunohistochemical Stain Is Sensitive and Specific for the Cytopathologic Identification of Intrapancreatic Ectopic Splenic Tissue"],"prefix":"10.1002","volume":"54","author":[{"given":"Adeyinka","family":"Akinsanya","sequence":"first","affiliation":[{"name":"Department of Pathology Indiana University School of Medicine Indianapolis Indiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9622-8688","authenticated-orcid":false,"given":"Jessica L.","family":"Muldoon","sequence":"additional","affiliation":[{"name":"Department of Pathology Indiana University School of Medicine Indianapolis Indiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed","family":"Mustafa","sequence":"additional","affiliation":[{"name":"Department of Pathology Indiana University School of Medicine Indianapolis Indiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6217-6402","authenticated-orcid":false,"given":"Bin","family":"Yang","sequence":"additional","affiliation":[{"name":"Diagnostic Institute, Cleveland Clinic Lerner College of Medicine Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1833-4642","authenticated-orcid":false,"given":"Hector","family":"Mesa","sequence":"additional","affiliation":[{"name":"University of Maryland School of Medicine Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4584-9222","authenticated-orcid":false,"given":"Omer","family":"Saeed","sequence":"additional","affiliation":[{"name":"Department of Pathology Indiana University School of Medicine Indianapolis Indiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,2,2]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI73186"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1210\/me.2009\u20100519"},{"issue":"5","key":"e_1_2_8_4_1","first-page":"1586","article-title":"Structural and Functional Abnormalities in the Spleen of an mFtz\u2010F1 Gene\u2010Disrupted Mouse","volume":"93","author":"Morohashi 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Cytopathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/dc.70093","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/dc.70093","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/dc.70093","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T15:56:49Z","timestamp":1777391809000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/dc.70093"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,2]]},"references-count":14,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,5]]}},"alternative-id":["10.1002\/dc.70093"],"URL":"https:\/\/doi.org\/10.1002\/dc.70093","archive":["Portico"],"relation":{},"ISSN":["8755-1039","1097-0339"],"issn-type":[{"value":"8755-1039","type":"print"},{"value":"1097-0339","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,2]]},"assertion":[{"value":"2025-10-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication 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