{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T08:03:38Z","timestamp":1775203418270,"version":"3.50.1"},"reference-count":32,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T00:00:00Z","timestamp":1770940800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T00:00:00Z","timestamp":1770940800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diagnostic Cytopathology"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Fine\u2010needle aspiration cytology (FNAC) is the primary screening test for thyroid nodules. The Bethesda System for Reporting Thyroid Cytopathology (TBSRTC) provides six diagnostic categories, each with an implied risk of malignancy (ROM). This study evaluated the performance of thyroid FNAC and the application of TBSRTC categories in a tertiary anatomical pathology service in South Africa.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective laboratory\u2010based audit included all 1703 thyroid FNACs processed between January 2016 and December 2021. Procedural details such as palpation versus ultrasound\u2010guided aspiration were not captured in the laboratory data set. TBSRTC category distribution was assessed, cytology\u2013histology correlation was performed for 315 cases with histology, and ROM was calculated. Diagnostic accuracy metrics, including sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and overall accuracy, were calculated using dichotomized cytology and histology results.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The mean proportion of FNAC reports that included a Bethesda category was 74.9%, and 854 (50.1%) cases were non\u2010diagnostic (Category I). The overall ROM, including category I and category II, was 7.4% if cases of low\u2010risk neoplasms were considered non\u2010malignant. The ROM for Categories I to V was within the published TBSRTC ranges, while the ROM for Category VI was lower (81.8% vs. 86%\u2013100%). The diagnostic accuracy was 54.8%, specificity 41.9%, sensitivity 73.4%, PPV 46.6%, and NPV 69.5%.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The rate of non\u2010diagnostic FNACs was higher than published estimates, suggesting the need for provider\u2010training on ultrasound\u2010guided FNAC, with rapid on\u2010site evaluation for specimen adequacy. There is a need to explore the factors that impact FNAC test performance in our setting.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/dc.70096","type":"journal-article","created":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T09:46:06Z","timestamp":1770975966000},"page":"359-370","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Correlation of Fine Needle Aspiration Cytology and Histopathology in Thyroid Nodules: A Six\u2010Year Study at a Tertiary Public Laboratory in the Western Cape Province, South Africa"],"prefix":"10.1002","volume":"54","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2999-7655","authenticated-orcid":false,"given":"Raymond","family":"Chimatira","sequence":"first","affiliation":[{"name":"Division of Anatomical Pathology University of Cape Town  Cape Town Western Cape South\u00a0Africa"},{"name":"Department of Anatomical Pathology National Health Laboratory Services, Groote Schuur Hospital  Cape Town Western Cape South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brendon","family":"Price","sequence":"additional","affiliation":[{"name":"Division of Anatomical Pathology University of Cape Town  Cape Town Western Cape South\u00a0Africa"},{"name":"Department of Anatomical Pathology National Health Laboratory Services, Groote Schuur Hospital  Cape Town Western Cape South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,2,13]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/cyt.12739"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/JCLINPATH\u20102016\u2010204022"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003\u20104819\u2010126\u20103\u2010199702010\u201000009"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.3109\/08958378.2014.955932"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-031-28046-7"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2023.0141"},{"key":"e_1_2_12_8_1","first-page":"1","volume-title":"Cellular Pathology Audit Template: An Audit of Reporting of Thyroid Cytology Specimens and Their Correlation With Thyroid Histology","author":"The Royal College of Pathologists (UK)","year":"2019"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.5604\/01.3001.0012.4712"},{"issue":"8","key":"e_1_2_12_10_1","first-page":"1347","article-title":"The Association Between Cytology and Histopathology in Thyroid Nodules Over a 6\u2010Year Period in an Urban Hospital in South Africa","volume":"113","author":"Chetty M.","year":"2023","journal-title":"South African Medical Journal"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1159\/000339959"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.4103\/CYTOJOURNAL.CYTOJOURNAL_32_17"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/J.1365\u20102303.2006.00335.X"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncy.22618"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.21037\/gs\u20102019\u2010catp\u201022"},{"key":"e_1_2_12_16_1","volume-title":"Guidance on the Reporting of Thyroid Cytology","author":"Cross P.","year":"2022"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13000\u2010019\u20100924\u2010z"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jnci.2015.06.001"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1186\/1755\u20107682\u20107\u201046\/TABLES\/3"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/dc.20731"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/CNCY.22201"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncy.21605"},{"key":"e_1_2_12_23_1","volume-title":"WHO Classification of Tumours Editorial Board Endocrine and Neuroendocrine Tumours","author":"Asa S. L.","year":"2022"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.4103\/cytojournal.cytojournal_53_17"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.4061\/2010\/379051"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamasurg.2022.4989"},{"key":"e_1_2_12_27_1","volume-title":"Diagnostic Yield of Ultrasound\u2010Guided Fine Needle Aspiration Biopsy (US\u2010Guided FNAB) and Post\u2010Surgical Histopathological Correlation of Thyroid Nodules in the Department of Radiology, Groote Schuur Hospital, Cape Town, South Africa Over a Two\u2010Year Period","author":"Matimati B.","year":"2022"},{"key":"e_1_2_12_28_1","volume-title":"Diagnostic Accuracy of Ultrasound\u2010Guided Fine Needle Aspiration Cytology of Thyroid Nodules at University Academic Hospital, Bloemfontein","author":"Ahmad F.","year":"2020"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.7196\/SAMJ.2022.v112i1.15906"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13044\u2010023\u201000169\u20101"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12902\u2010019\u20100429\u20105"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.4102\/SAJR.V23I1.1749"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2006.16.55"}],"container-title":["Diagnostic Cytopathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/dc.70096","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/dc.70096","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/dc.70096","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T05:57:56Z","timestamp":1775195876000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/dc.70096"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,13]]},"references-count":32,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,5]]}},"alternative-id":["10.1002\/dc.70096"],"URL":"https:\/\/doi.org\/10.1002\/dc.70096","archive":["Portico"],"relation":{},"ISSN":["8755-1039","1097-0339"],"issn-type":[{"value":"8755-1039","type":"print"},{"value":"1097-0339","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,13]]},"assertion":[{"value":"2025-04-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-01","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-13","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}