{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T08:03:41Z","timestamp":1775203421014,"version":"3.50.1"},"reference-count":43,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T00:00:00Z","timestamp":1773014400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T00:00:00Z","timestamp":1773014400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diagnostic Cytopathology"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Pericardial effusion frequently complicates the clinical course of patients with malignancy; however, progression to cardiac tamponade is uncommon and may be life\u2010threatening. Lymphoma constitutes an important etiology, particularly diffuse large B\u2010cell lymphoma (DLBCL), whereas T\u2010cell variants are exceedingly rare.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case Presentation<\/jats:title>\n                    <jats:p>A 26\u2010year\u2010old Syrian male presented with dyspnea, fatigue, and B symptoms. Radiologic evaluation demonstrated massive pericardial and pleural effusions, extensive lymphadenopathy, skeletal deposits, and bilateral renal involvement. Laboratory findings revealed anemia, thrombocytopenia, and marked hepatic enzyme elevation. Emergency echocardiography\u2010guided pericardiocentesis drained 1000\u2009mL of hemorrhagic exudate containing immature lymphoid cells. PET\u2010CT demonstrated disseminated disease, and flow cytometry of the pericardial fluid confirmed peripheral T\u2010cell lymphoma, not otherwise specified (PTCL\u2010NOS). Because of progressive hemodynamic deterioration, systemic chemotherapy was initiated immediately based on flow\u2010cytometric results without awaiting final lymph\u2010node histopathology. CHOEP therapy led to rapid and marked clinical improvement within 24\u2009h and complete effusion resolution after the first cycle.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>A literature search (2021\u20132025) identified 34 cases of lymphoma\u2010associated cardiac tamponade, 94% of which were B\u2010cell derived. Only two involved T\u2010cell lymphoma, and none described concurrent renal infiltration. The present case is, to our knowledge, the first report of PTCL presenting simultaneously with pericardial tamponade and renal involvement and highlights the life\u2010saving importance of prompt, flow\u2010cytometry\u2010guided chemotherapy initiation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Peripheral T\u2010cell lymphoma may rarely manifest with acute cardiac tamponade and multiorgan dissemination. Urgent drainage followed by early chemotherapy\u2014sometimes initiated before histopathologic confirmation\u2014can be lifesaving. Recognition of such patterns may aid timely diagnosis and improve outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/dc.70110","type":"journal-article","created":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T04:19:47Z","timestamp":1773116387000},"page":"388-398","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["When Lymphoma Reaches the Heart: A Narrative Review of Cardiac Tamponade Presentations"],"prefix":"10.1002","volume":"54","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5244-3733","authenticated-orcid":false,"given":"Veysel","family":"Erol","sequence":"first","affiliation":[{"name":"Department of Hematology Kahramanmara\u015f Necip Faz\u0131l City Hospital  Kahramanmara\u015f 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