{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T14:27:31Z","timestamp":1780324051332,"version":"3.54.1"},"reference-count":24,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T00:00:00Z","timestamp":1773878400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T00:00:00Z","timestamp":1773878400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diagnostic Cytopathology"],"published-print":{"date-parts":[[2026,7]]},"abstract":"ABSTRACT<\/jats:title>\n \n Hyalinizing clear cell carcinoma (HCCC) of the lung is an exceedingly rare salivary gland\u2010type neoplasm with limited cytomorphologic description. We report a case highlighting these features. A 3\u2009mm incidental left\u2010airway lesion enlarged to 7\u2009mm over 5 months, prompting radial endobronchial ultrasound (EBUS)\u2010guided transbronchial biopsy. Touch preparations revealed abundant bland tumor cells with small round to oval nuclei, smooth nuclear membranes, and scant slightly dense cytoplasm. Scattered cells showed clear or mucinous cytoplasm. The cells displayed round, columnar, or polygonal shapes and were arranged in nests, sheets, cohesive three\u2010dimensional clusters, and acinar or tubular structures within a homogeneous paucicellular fibrotic stroma. Histology demonstrated tumor cells in trabeculae, nests, and cords with occasional glands and mucinous microcysts set in hyalinized stroma. Most tumors cells had eosinophilic cytoplasm with scattered clear and mucinous cells. Immunohistochemically, tumor cells were positive for p40, DOG1, CK AE1\/AE3, CAM5.2, CK5\/6, CK7, EMA, and p63, and negative for TTF1; stromal cells were positive for SMA. Mucinous cells were mucicarmine\u2010positive, and the Ki\u201067 index was very low (~2%). Molecular analysis identified an\n EWSR1<\/jats:italic>\n ::\n ATF1<\/jats:italic>\n fusion and\n SUZ12<\/jats:italic>\n and\n WRN<\/jats:italic>\n mutations. The tumor mutational burden was 5.4 mutations per megabase. Segmentectomy confirmed HCCC with no nodal metastasis (stations 5, 9, 10, 11). Recognition of the cytomorphology, immunohistochemical profile, and characteristic\n EWSR1<\/jats:italic>\n ::\n ATF1<\/jats:italic>\n or\n EWSR1<\/jats:italic>\n ::\n CREM<\/jats:italic>\n fusions is essential for accurate diagnosis of primary pulmonary HCCC.\n <\/jats:p>","DOI":"10.1002\/dc.70114","type":"journal-article","created":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T03:49:52Z","timestamp":1773978592000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Cytomorphology and Molecular Profile of Hyalinizing Clear Cell Carcinoma of the Lung: A Case With Mucinous Differentiation"],"prefix":"10.1002","volume":"54","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-7497-5902","authenticated-orcid":false,"given":"Jeffrey Zijie","family":"Lin","sequence":"first","affiliation":[{"name":"Washington University in Saint Louis Saint Louis Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3000-3686","authenticated-orcid":false,"given":"Lucy","family":"Jager","sequence":"additional","affiliation":[{"name":"Department of Pathology Northwestern University, Feinberg School of Medicine, Northwestern Memorial Hospital Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,3,19]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13000-022-01200-z"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1177\/10668969221137516"},{"issue":"7","key":"e_1_2_8_4_1","first-page":"728","article-title":"Clinicopathological Features and Molecular Genetic Changes of Lung Salivary Gland\u2010Type Clear Cell Carcinoma","volume":"50","author":"Xue Q. Q.","year":"2021","journal-title":"Zhonghua Bing Li Xue Za Zhi"},{"issue":"3","key":"e_1_2_8_5_1","first-page":"509","article-title":"Primary Pulmonary Hyalinising Clear Cell Carcinoma: Two Cases and Literature Review","volume":"44","author":"Di J.","year":"2022","journal-title":"Malaysian Journal of Pathology"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/dc.24285"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000034101"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13000-022-01216-5"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/aqx048"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/his.14942"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAI.0b013e3182606f2d"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anndiagpath.2020.151698"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pathol.2016.04.011"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1080\/08998280.2017.11929633"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2016.06.029"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12105-017-0820-3"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41379-018-0025-7"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41379-022-01100-z"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lungcan.2021.07.011"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000002092"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e31825485c5"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/pin.13030"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12105-018-0953-z"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000000364"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2559.2000.00955-6.x"}],"container-title":["Diagnostic Cytopathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/dc.70114","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/dc.70114","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/dc.70114","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T13:50:40Z","timestamp":1780321840000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/dc.70114"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,19]]},"references-count":24,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["10.1002\/dc.70114"],"URL":"https:\/\/doi.org\/10.1002\/dc.70114","archive":["Portico"],"relation":{},"ISSN":["8755-1039","1097-0339"],"issn-type":[{"value":"8755-1039","type":"print"},{"value":"1097-0339","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,19]]},"assertion":[{"value":"2026-01-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-05","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-19","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}