{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T19:33:07Z","timestamp":1783020787218,"version":"3.54.6"},"reference-count":18,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T00:00:00Z","timestamp":1777334400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T00:00:00Z","timestamp":1777334400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diagnostic Cytopathology"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Patients who undergo total thyroidectomy for primary malignant neoplasms are routinely monitored for recurrence in the thyroid bed. Fine\u2010needle aspiration (FNA) cytology is often performed to evaluate suspicious thyroid bed lesions, but its diagnostic reliability and correlation with thyroglobulin (Tg) levels remain incompletely characterized.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A retrospective review was performed of thyroid bed FNAs diagnosed between 2008 and 2023 at Rush University Medical Center. Clinical data, cytologic findings, surgical pathology follow\u2010up, and serum Tg levels were analyzed. Cytologic diagnoses were classified using the Bethesda System for Reporting Thyroid Cytopathology (TBS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Forty\u2010one thyroid bed FNAs from 38 patients (32 females, six males; age 20\u201384\u2009years, mean 52) were identified. The original thyroidectomy specimens included 28 papillary thyroid carcinoma (PTC), two follicular carcinoma (FC), two medullary carcinomas (MC), two carcinoma NOS, one poorly differentiated carcinoma, and three multinodular goiters. Cytologic categories included TBS VI (10), V (4), IV (2), III (2), II (12), and I (11; 27% nondiagnostic). Sixteen patients underwent subsequent surgical biopsy\/resection; 12 had TBS III or higher cytology, all of which were malignant on histology (100% concordance). Of seven patients with available Tg levels in this group, 3 were normal (&lt;\u20091\u2009ng\/mL) and four were increased (&gt;\u20091\u2009ng\/mL). Among four patients with nondiagnostic cytology, one showed malignancy and elevated Tg.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Thyroid bed FNA is a reliable method for detecting recurrent thyroid carcinoma, showing 100% cytohistologic concordance for TBS III and above. Tg is not universally elevated in recurrent tumors (sensitivity 57%), but an increased Tg level in the setting of nondiagnostic FNA warrants further evaluation. The 27% rate of unsatisfactory specimens likely reflects postsurgical scarring, which can clinically mimic recurrence.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/dc.70133","type":"journal-article","created":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T04:51:49Z","timestamp":1777438309000},"page":"556-561","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Clinical and Cytological Features of Thyroid Bed Fine\u2010Needle Aspirations"],"prefix":"10.1002","volume":"54","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-6749-9235","authenticated-orcid":false,"given":"Sajjad","family":"Mohammedjoead","sequence":"first","affiliation":[{"name":"Department of Pathology Rush University Medical Center  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-9734-4454","authenticated-orcid":false,"given":"Aurora","family":"Zaccagnino","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Medicine University Hospital of Pisa  Pisa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-0597-185X","authenticated-orcid":false,"given":"Cosimo","family":"Custoza","sequence":"additional","affiliation":[{"name":"Pathological Anatomy Laboratory San Donato Hospital  Arezzo Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5491-552X","authenticated-orcid":false,"given":"Vijaya","family":"Reddy","sequence":"additional","affiliation":[{"name":"Department of Pathology Rush University Medical Center  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4588-6282","authenticated-orcid":false,"given":"Paolo","family":"Gattuso","sequence":"additional","affiliation":[{"name":"Department of Pathology Rush University Medical Center  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,28]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1309\/AJCPPHLWMI3JV4LA"},{"issue":"3","key":"e_1_2_10_3_1","first-page":"251","article-title":"Pitfalls in Thyroid Cytopathology","volume":"51","author":"Rossi E. D.","year":"2019","journal-title":"Pathology"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1309\/AJCPD60AHRUCMDPF"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncy.21202"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/1742-6413-2-12"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/aqaa127"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anndiagpath.2014.03.003"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jasc.2018.08.004"},{"issue":"12","key":"e_1_2_10_10_1","first-page":"895","article-title":"Ancillary Molecular Testing of Indeterminate Thyroid Nodules","volume":"126","author":"Rossi E. D.","year":"2018","journal-title":"Cancer Cytopathology"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1530\/EJE\u201014\u20100148"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1159\/000535907"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1159\/000339959"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2017.0500"},{"issue":"2","key":"e_1_2_10_15_1","first-page":"84","article-title":"Bethesda System for Reporting Thyroid Cytopathology\u2014An Updated Review","volume":"3","author":"Han M.","year":"2023","journal-title":"Journal of Clinical and Translational Pathology"},{"issue":"9","key":"e_1_2_10_16_1","first-page":"1039","article-title":"The 2023 Bethesda System for Reporting Thyroid Cytopathology","volume":"33","author":"Ali S. Z.","year":"2023","journal-title":"Thyroid"},{"issue":"9","key":"e_1_2_10_17_1","first-page":"939","article-title":"Diagnostic Accuracy of the Bethesda System for Reporting Thyroid Cytopathology (TBSRTC): An Institutional Experience","volume":"51","author":"Rai K.","year":"2023","journal-title":"Diagnostic Cytopathology"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/cyt.12062"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.12998\/wjcc.v4.i2.38"}],"container-title":["Diagnostic Cytopathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/dc.70133","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/dc.70133","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/dc.70133","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T18:09:41Z","timestamp":1783015781000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/dc.70133"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,28]]},"references-count":18,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["10.1002\/dc.70133"],"URL":"https:\/\/doi.org\/10.1002\/dc.70133","archive":["Portico"],"relation":{},"ISSN":["8755-1039","1097-0339"],"issn-type":[{"value":"8755-1039","type":"print"},{"value":"1097-0339","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,28]]},"assertion":[{"value":"2025-12-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-22","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-28","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}