{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T19:31:13Z","timestamp":1783020673631,"version":"3.54.6"},"reference-count":12,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T00:00:00Z","timestamp":1778457600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T00:00:00Z","timestamp":1778457600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diagnostic Cytopathology"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Serous cystadenoma (SCA), pancreas is a rare benign neoplasm comprising &lt;\u20091% of primary pancreatic lesions. Although preoperative imaging and biochemical cyst fluid analysis have been described for SCA, the pathognomic features are appreciable only in a handful of cases. Endoscopic ultrasound guided fine needle aspiration\/Biopsy (EUS FNA\/B) and cell block of SCA suffers from low cellular yield and nonspecific diagnosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material and Methods<\/jats:title>\n                    <jats:p>This was a combined retrospective and prospective study conducted during a period of 6\u2009years (January 2017\u2013December 2023) at a tertiary care referral centre. Clinical history, primary imaging and EUS characteristics were noted. Immunohistochemical (IHC) expression of alpha inhibin, Calponin, Glucose transporter 1 (GLUT 1), Synaptophysin and Chromogranin was evaluated in the cases of SCA and compared with expression of these immunomarkers in 20 cases of neuroendocrine tumour, pancreas (Grades I and II).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Fourteen cases of indeterminate SCA were identified over a period of 6\u2009years (January 2017\u2013December 2023). Cell block supplemented with immunohistochemistry(IHC) was able to provide a definitive diagnosis in 92.3% (12\/13) cases in this series. Thus, diagnostic certainty improved from 30.8% on the basis of morphology alone to 92.3% with FNA\/B and cell block and IHC.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Thus, EUS FNA\/B supplemented with cell block and IHC can provide an unequivocal preoperative diagnosis of SCA. IHC panel comprising alpha inhibin, GLUT 1, synaptophysin and chromogranin can provide a sufficient level of evidence to categorize the lesion as SCA.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/dc.70143","type":"journal-article","created":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T04:19:36Z","timestamp":1778559576000},"page":"582-596","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Endoscopic Ultrasound Guided Fine Needle Aspiration\/Biopsy and Cell Block in Indeterminate Serous Cyst Adenoma, Pancreas: Clinicoradiologic and Cytopathologic Study"],"prefix":"10.1002","volume":"54","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8952-1595","authenticated-orcid":false,"given":"Thakur","family":"Abha","sequence":"first","affiliation":[{"name":"Department of Cytopathology Medanta\u2010The Medicity  Gurgaon Haryana India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarin","family":"Haimanti","sequence":"additional","affiliation":[{"name":"Department of Cytopathology Medanta\u2010The Medicity  Gurgaon Haryana India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Panchal","family":"Hitesh","sequence":"additional","affiliation":[{"name":"Institute of Digestive and Hepatobiliary Sciences, Medanta\u2010The Medicity  Gurgaon Haryana India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pandey","family":"Arvind","sequence":"additional","affiliation":[{"name":"Department of Radiology and Imaging Medanta\u2010The Medicity  Gurgaon Haryana India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lipi","family":"Lipika","sequence":"additional","affiliation":[{"name":"Department of Histopathology Medanta\u2010The Medicity  Gurgaon Haryana India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Puri","family":"Rajesh","sequence":"additional","affiliation":[{"name":"Institute of Digestive and Hepatobiliary Sciences, Medanta\u2010The Medicity  Gurgaon Haryana India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,11]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.5858\/arpa.2017-0195-RS"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.23346"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.4103\/eus.eus_11_19"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diii.2016.08.005"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.suronc.2010.12.002"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0040-1721293"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.semdp.2014.08.009"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm12237306"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.21911"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncy.21347"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAI.0b013e3181f5023d"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1159\/000452471"}],"container-title":["Diagnostic Cytopathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/dc.70143","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/dc.70143","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/dc.70143","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T18:09:23Z","timestamp":1783015763000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/dc.70143"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,11]]},"references-count":12,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["10.1002\/dc.70143"],"URL":"https:\/\/doi.org\/10.1002\/dc.70143","archive":["Portico"],"relation":{},"ISSN":["8755-1039","1097-0339"],"issn-type":[{"value":"8755-1039","type":"print"},{"value":"1097-0339","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,11]]},"assertion":[{"value":"2026-01-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-02","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-11","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}