{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T12:57:13Z","timestamp":1785589033356,"version":"3.56.0"},"reference-count":25,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T00:00:00Z","timestamp":1780012800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T00:00:00Z","timestamp":1780012800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diagnostic Cytopathology"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>High\u2010risk human papillomavirus (hrHPV) is a well\u2010established etiological agent in the development of cervical cancer. As molecular HPV testing becomes increasingly integrated into cervical cancer screening protocols, the correlation between cytomorphologic features and specific hrHPV types warrants further investigation. This study aimed to assess the predictive value of cytological features in cases with concurrent positive PAP smear results and detection of a single hrHPV category (HPV16, HPV18\/45, or other pooled hrHPV types).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>In this retrospective study, 490 cases with abnormal Pap smear findings and a single hrHPV category (HPV16, HPV18\/45, or other pooled hrHPV types) were evaluated. hrHPV detection was performed using a real\u2010time PCR\u2013based assay (Aptima HPV). Liquid\u2010based cytology slides were systematically reviewed for a spectrum of cytomorphologic features, and their associations with hrHPV categories were analyzed using appropriate statistical methods, including false discovery rate (FDR) correction.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Initial analyses demonstrated a statistically significant association between classical koilocytosis and other pooled hrHPV types (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), as well as associations between HPV16 positivity and nuclear hyperchromasia (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.047) and nuclear membrane irregularity (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.017). However, following Benjamini\u2013Hochberg FDR adjustment, only the association between classical koilocytosis and other pooled hrHPV types remained statistically significant (adjusted\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.011). No significant correlations were identified between hrHPV categories and other evaluated cytomorphologic features.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our findings indicate that while cytomorphology alone is not fully adequate for precise hrHPV typing, it may offer supportive value, particularly in settings where HPV testing is not readily available.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/dc.70153","type":"journal-article","created":{"date-parts":[[2026,5,30]],"date-time":"2026-05-30T05:26:47Z","timestamp":1780118807000},"page":"637-643","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Cytomorphologic Findings Associated With High\u2010Risk\n                    <scp>HPV<\/scp>\n                    Categories in\n                    <scp>PAP<\/scp>\n                    Smears"],"prefix":"10.1002","volume":"54","author":[{"given":"Berfin Ekin","family":"Yildiz","sequence":"first","affiliation":[{"name":"Department of Pathology, Haydarpasa Numune Training and Research Hospital University of Health Sciences Turkey  Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nermin","family":"Ko\u00e7","sequence":"additional","affiliation":[{"name":"Department of Pathology, Haydarpasa Numune Training and Research Hospital University of Health Sciences Turkey  Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,29]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096\u20109896(199909)189:1<12::AID\u2010PATH431>3.0.CO;2\u2010F"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijgo.13865"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2026.1304"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11606\u2010016\u20103772\u20105"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/v10120729"},{"key":"e_1_2_10_7_1","volume-title":"National Cancer Control Program: Cervical Cancer Screening in Turkey","author":"Republic of Turkey Ministry of Health","year":"2022"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.23736\/S0026\u20104784.19.04468\u2010X"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1080\/13697137.2018.1439917"},{"key":"e_1_2_10_10_1","unstructured":"Kamu Hastaneleri Genel M\u00fcd\u00fcrl\u00fc\u011f\u00fc Kamu Sa\u011fl\u0131k Hizmetleri Fiyat Tarifesi 26.07.2023 [Internet]. Fiyat Tarifeleri(2023) https:\/\/khgmfinansalanalizdb.saglik.gov.tr\/TR\u201040231\/fiyat\u2010tarifeleri.html."},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-11074-5"},{"key":"e_1_2_10_12_1","volume-title":"World Cancer Report","author":"Boyle P.","year":"2008"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1067\/mob.2003.164"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1159\/000332452"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.2008.059881"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.24875\/ciru.22000400"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.25775"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/978\u20103\u2010031\u201006573\u20106_16"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/dc.23941"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13402\u2010015\u20100252\u20106"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1006\/gyno.2001.6336"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc2050"},{"issue":"6","key":"e_1_2_10_23_1","first-page":"477","article-title":"A Comparison Between Real\u2010Time Polymerase Chain Reaction and Hybrid Capture 2 for Human Papillomavirus DNA Quantitation","volume":"12","author":"Gravitt P. 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