{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T09:44:13Z","timestamp":1785836653880,"version":"3.56.0"},"reference-count":8,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T00:00:00Z","timestamp":1780531200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T00:00:00Z","timestamp":1780531200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diagnostic Cytopathology"],"abstract":"ABSTRACT<\/jats:title>\n \n Background<\/jats:title>\n \n Primary pulmonary mesenchymal neoplasms with\n EWSR1::CREM<\/jats:italic>\n fusion are rare. These lesions are challenging to diagnose by morphology and immunohistochemistry alone.\n <\/jats:p>\n <\/jats:sec>\n \n Case<\/jats:title>\n \n A 66\u2010year\u2010old woman (ex\u2010smoker) was found to have a 1.3\u2010cm right lower lobe lung nodule that had grown very slowly over a 9\u2010year period. Fine\u2010needle aspiration and core biopsy demonstrated papillary fragments lined by epithelioid cells with underlying neoplastic stromal cells arranged in sheets, cords, and clusters. There was no significant atypia, necrosis, or mitotic activity. An extensive panel of immunostains was inconclusive. Wedge resection of the nodule showed a well\u2010circumscribed neoplasm with the same bland morphology seen in the biopsy. Lymph nodes were negative. Given the bland cytology and inconclusive immunophenotype, targeted next\u2010generation sequencing was performed, which revealed an\n EWSR1::CREM<\/jats:italic>\n gene fusion. Based on these findings, a low\u2010grade fusion\u2010driven mesenchymal neoplasm was favored.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n This case highlights the role of next\u2010generation sequencing in establishing the diagnosis in rare cytologically bland pulmonary mesenchymal neoplasms in which conventional cytomorphology and immunohistochemistry fail to reveal a specific diagnosis.<\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/dc.70156","type":"journal-article","created":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T04:02:47Z","timestamp":1780632167000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Primary Pulmonary Mesenchymal Neoplasm With\n EWSR1::CREM<\/i>\n Fusion: Cytologic Findings and Molecular Diagnosis"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6590-4084","authenticated-orcid":false,"given":"Priya","family":"Upadhyay","sequence":"first","affiliation":[{"name":"Integrative Pathobiology Graduate Program University of California, Davis Davis California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanjay","family":"Mukhopadhyay","sequence":"additional","affiliation":[{"name":"Department of Pathology Cleveland Clinic Foundation Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-6362-1043","authenticated-orcid":false,"given":"Swikrity U.","family":"Baskota","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine University of California Davis Medical Center Sacramento California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,4]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.21037\/jtd.2018.12.04"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000000788"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/pin.13030"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000001376"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12105-022-01476-z"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e318227e4d2"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e31814b18fb"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/jclinpath-2013-201857"}],"container-title":["Diagnostic Cytopathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/dc.70156","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/dc.70156","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/dc.70156","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T08:48:04Z","timestamp":1785833284000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/dc.70156"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,4]]},"references-count":8,"alternative-id":["10.1002\/dc.70156"],"URL":"https:\/\/doi.org\/10.1002\/dc.70156","archive":["Portico"],"relation":{},"ISSN":["8755-1039","1097-0339"],"issn-type":[{"value":"8755-1039","type":"print"},{"value":"1097-0339","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,4]]},"assertion":[{"value":"2026-04-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-28","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-04","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"dc.70156"}}