{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T15:29:25Z","timestamp":1786116565412,"version":"build-2736575974"},"reference-count":17,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T00:00:00Z","timestamp":1785974400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T00:00:00Z","timestamp":1785974400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diagnostic Cytopathology"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Intraductal tubulopapillary neoplasm (ITPN) is a rare pancreatic intraductal tumor and recognized precursor of pancreatic ductal adenocarcinoma, accounting for less than 1% of pancreatic exocrine neoplasms and about 3% of intraductal pancreatic neoplasms. Herein, we report an 82\u2010year\u2010old woman with a pancreatic head mass and miliary pulmonary nodules radiologically concerning for pancreatic adenocarcinoma, evaluated by endoscopic ultrasound\u2010guided fine\u2010needle aspiration. Cytology revealed a hypercellular specimen with papillary fronds and clusters of cells arranged in tubular formations with no extracellular as well as intracellular mucin identified; cell block sections showed tubular, cribriform, and papillary architecture with focal high\u2010grade dysplasia. Immunohistochemistry demonstrated diffuse MUC1 positivity with patchy CK7 and CK19 expression and negativity for MUC2, GATA3, and TTF\u20101, supporting a diagnosis of ITPN. This case highlights the cytomorphologic and immunophenotypic features of pancreatic ITPN on FNA and emphasizes the importance of distinguishing it from intraductal papillary mucinous neoplasm and other pancreatic neoplasms in limited cytology samples.<\/jats:p>","DOI":"10.1002\/dc.70192","type":"journal-article","created":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T10:48:03Z","timestamp":1786013283000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Endoscopic Ultrasound\u2010Guided Fine Needle Aspiration Diagnosis of Pancreatic Intraductal Tubulopapillary Neoplasm: A Cytology Case Report"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-2807-6330","authenticated-orcid":false,"given":"Ayesha","family":"Usman","sequence":"first","affiliation":[{"name":"Department of Pathology Montefiore Medical Center, Albert Einstein College of Medicine  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9608-7566","authenticated-orcid":false,"given":"Shweta","family":"Gera","sequence":"additional","affiliation":[{"name":"Department of Pathology Montefiore Medical Center, Albert Einstein College of Medicine  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4893-3873","authenticated-orcid":false,"given":"Amarpreet","family":"Bhalla","sequence":"additional","affiliation":[{"name":"Department of Pathology Montefiore Medical Center, Albert Einstein College of Medicine  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8339-2219","authenticated-orcid":false,"given":"Antonio","family":"Cajigas","sequence":"additional","affiliation":[{"name":"Department of Pathology Montefiore Medical Center, Albert Einstein College of Medicine  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,6]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"304","volume-title":"WHO Classification of Tumours of the Digestive System","author":"Bosman F. T.","year":"2010"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.mpa.0000148513.69873.4b"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/pas.0b013e3181a162e5"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2023.02.006"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/pas.0000000000000782"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.25259\/cytojournal_71_2023"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.5858\/133.3.423"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1159\/000448386"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/dc.20880"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/dc.22890"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/dc.23083"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/dc.23366"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440\u20101827.2012.02791.x"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.pas.0000213376.09795.9f"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/his.14698"},{"key":"e_1_2_7_17_1","doi-asserted-by":"crossref","first-page":"1760","DOI":"10.1038\/modpathol.2017.60","article-title":"Pancreatic Intraductal Tubulopapillary Neoplasm Is Genetically Distinct From Intraductal Papillary Mucinous Neoplasm and Ductal Adenocarcinoma","volume":"30","author":"Basturk O.","year":"2017","journal-title":"Modern Pathology"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41379\u2010022\u201001143\u20102"}],"container-title":["Diagnostic Cytopathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/dc.70192","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/dc.70192","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/dc.70192","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T10:48:05Z","timestamp":1786013285000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/dc.70192"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,6]]},"references-count":17,"alternative-id":["10.1002\/dc.70192"],"URL":"https:\/\/doi.org\/10.1002\/dc.70192","archive":["Portico"],"relation":{},"ISSN":["8755-1039","1097-0339"],"issn-type":[{"value":"8755-1039","type":"print"},{"value":"1097-0339","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,6]]},"assertion":[{"value":"2026-03-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-30","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-06","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"dc.70192"}}