{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T07:32:16Z","timestamp":1786433536019,"version":"build-2736575974"},"reference-count":17,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T00:00:00Z","timestamp":1786406400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T00:00:00Z","timestamp":1786406400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diagnostic Cytopathology"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Fluid overload\u2010associated B\u2010cell lymphoma (FO\u2010LBCL) is a B\u2010cell neoplasm that presents as serous effusions without detectable tumor masses and Kaposi sarcoma\u2010associated herpesvirus (KSHV)\/human herpesvirus 8 (HHV8) infection. Here, we report a case of an 81\u2010year\u2010old female patient with FO\u2010LBCL (Stage IVA) who presented with pericardial and pleural effusions. The patient had no underlying medical condition that could lead to fluid overload. Cytological examination of both effusions revealed medium\u2010 to large\u2010sized lymphoid cells with high nucleocytoplasmic ratios, irregular nuclei, dense chromatin, prominent nucleoli, mitotic figures, basophilic cytoplasm, and lymphoglandular bodies. A cell block of the pleural fluid effusion showed that atypical lymphoid cells were positive for CD20 and CD79a, and negative for CD3, KSHV\/HHV\u20108, and Epstein\u2013Barr virus. The Ki\u201067 labeling index was 95%. The patient underwent systemic chemotherapy and achieved complete remission without pleural or pericardial recurrence during the 3\u2010year follow\u2010up period. As FO\u2010LBCL is diagnosed based on cytological material, together with clinical and imaging findings, immunohistochemical analysis of the cell block is useful for confirming the diagnosis and selecting tailored therapies.<\/jats:p>","DOI":"10.1002\/dc.70198","type":"journal-article","created":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T07:19:36Z","timestamp":1786432776000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Diagnostic Usefulness of Cell Block Samples in Fluid Overload\u2010Associated Large B\u2010Cell Lymphoma"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-7190-4839","authenticated-orcid":false,"given":"Hiroyuki","family":"Okanishi","sequence":"first","affiliation":[{"name":"Division of Diagnostic Pathology Osaka Medical and Pharmaceutical University Hospital  Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7043-8820","authenticated-orcid":false,"given":"Hiroko","family":"Kuwabara","sequence":"additional","affiliation":[{"name":"Division of Diagnostic Pathology Osaka Medical and Pharmaceutical University Hospital  Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-0368-3799","authenticated-orcid":false,"given":"Hiroko","family":"Nakayama","sequence":"additional","affiliation":[{"name":"Division of Diagnostic Pathology Osaka Medical and Pharmaceutical University Hospital  Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-4047-2176","authenticated-orcid":false,"given":"Mayo","family":"Odaka","sequence":"additional","affiliation":[{"name":"Division of Diagnostic Pathology Osaka Medical and Pharmaceutical University Hospital  Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-6891-6041","authenticated-orcid":false,"given":"Kozue","family":"Ariga","sequence":"additional","affiliation":[{"name":"Division of Diagnostic Pathology Osaka Medical and Pharmaceutical University Hospital  Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-9838-9572","authenticated-orcid":false,"given":"Isako","family":"Kataoka","sequence":"additional","affiliation":[{"name":"Division of Diagnostic Pathology Osaka Medical and Pharmaceutical University Hospital  Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mari","family":"Tomiuka","sequence":"additional","affiliation":[{"name":"Division of Diagnostic Pathology Osaka Medical and Pharmaceutical University Hospital  Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-6565-8511","authenticated-orcid":false,"given":"Mayumi","family":"Uragami","sequence":"additional","affiliation":[{"name":"Division of Diagnostic Pathology Osaka Medical and Pharmaceutical University Hospital  Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-0980-0165","authenticated-orcid":false,"given":"Chihiro","family":"Deguchi","sequence":"additional","affiliation":[{"name":"Division of Diagnostic Pathology Osaka Medical and Pharmaceutical University Hospital  Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-2243-1536","authenticated-orcid":false,"given":"Shizuka","family":"Ono","sequence":"additional","affiliation":[{"name":"Division of Diagnostic Pathology Osaka Medical and Pharmaceutical University Hospital  Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-0362-2043","authenticated-orcid":false,"given":"Reika","family":"Takeda","sequence":"additional","affiliation":[{"name":"Division of Diagnostic Pathology Osaka Medical and Pharmaceutical University Hospital  Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-3955-701X","authenticated-orcid":false,"given":"Yoshitaka","family":"Kurisu","sequence":"additional","affiliation":[{"name":"Division of Diagnostic Pathology Osaka Medical and Pharmaceutical University Hospital  Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3860-0293","authenticated-orcid":false,"given":"Yoshinobu","family":"Hirose","sequence":"additional","affiliation":[{"name":"Division of Diagnostic Pathology Osaka Medical and Pharmaceutical University Hospital  Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6107-8918","authenticated-orcid":false,"given":"Yuuki","family":"Kinoshita","sequence":"additional","affiliation":[{"name":"Division of Hematology Osaka Medical and Pharmaceutical University Hospital  Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-3346-9453","authenticated-orcid":false,"given":"Taiji","family":"Yokote","sequence":"additional","affiliation":[{"name":"Division of Hematology Osaka Medical and Pharmaceutical University Hospital  Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,11]]},"reference":[{"key":"e_1_2_10_2_1","first-page":"503","volume-title":"WHO Classification of Tumours","author":"Jong D.","year":"2024"},{"key":"e_1_2_10_3_1","first-page":"541","volume-title":"WHO Classification of Tumours","author":"Said J. 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M.","year":"2019","journal-title":"Modern Pathology"},{"key":"e_1_2_10_14_1","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1002\/dc.2840120303","article-title":"Fine\u2010Needle Aspiration Biopsy and Imprint Cytology of Small Non\u2010Cleaved Cell (Burkitt's) Lymphoma","volume":"12","author":"Stastny J. F.","year":"1995","journal-title":"Diagnostic Cytopathology"},{"key":"e_1_2_10_15_1","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1002\/cncy.20160","article-title":"Cytopathology of \u201cDouble\u2010Hit\u201d Non\u2010Hodgkin Lymphoma","volume":"119","author":"Elkins C. T.","year":"2011","journal-title":"Cancer Cytopathology"},{"key":"e_1_2_10_16_1","first-page":"539","volume-title":"WHO Classification of Tumours","author":"Naresh K. N.","year":"2024"},{"key":"e_1_2_10_17_1","doi-asserted-by":"crossref","first-page":"24","DOI":"10.4103\/joc.joc_71_25","article-title":"Diagnostic Utility of Cytology and Cell Block With Immunohistochemistry in Detection of Peritoneal Metastasis in Gynecological Malignancies","volume":"43","author":"Kaur D.","year":"2026","journal-title":"Journal of Cytology"},{"key":"e_1_2_10_18_1","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1056\/NEJMoa2115304","article-title":"Polatuzumab Vedoin in Previously Untreated Diffuse Large B\u2010Cell Lymphoma","volume":"386","author":"Tilly H.","year":"2022","journal-title":"New England Journal of Medicine"}],"container-title":["Diagnostic Cytopathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/dc.70198","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/dc.70198","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/dc.70198","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T07:19:39Z","timestamp":1786432779000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/dc.70198"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,11]]},"references-count":17,"alternative-id":["10.1002\/dc.70198"],"URL":"https:\/\/doi.org\/10.1002\/dc.70198","archive":["Portico"],"relation":{},"ISSN":["8755-1039","1097-0339"],"issn-type":[{"value":"8755-1039","type":"print"},{"value":"1097-0339","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,11]]},"assertion":[{"value":"2026-05-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-05","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-11","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"dc.70198"}}