{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T12:07:09Z","timestamp":1788955629381,"version":"build-2803163510"},"reference-count":17,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T00:00:00Z","timestamp":1788912000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T00:00:00Z","timestamp":1788912000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diagnostic Cytopathology"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Sclerosing polycystic adenoma (SPA) is a rare benign salivary gland neoplasm composed of a lobular proliferation of ducts lined by cuboidal, columnar, apocrine, and foamy vacuolated cells, and acinar structures having large cells with intracytoplasmic bright eosinophilic granules in a collagenous stroma with lymphoid aggregates. Due to its rarity, its cytological features are not widely documented. The spectrum of cell types may lead to it being mistaken for malignancy on cytological examination. This 29\u2010year\u2010old male presented with a right parotid swelling measuring 4\u2009cm on ultrasonography. Fine needle aspirate showed tightly cohesive three\u2010dimensional papillaroid and acinar clusters along with flat sheets of large polygonal cells with abundant coarse granular to vacuolated cytoplasm in a dirty fluidy background. Oncocytoid and apocrine\u2010appearing cells were present. The background showed few lymphocytes and stromal fragments. A diagnosis of a malignant neoplasm, possibly oncocytic mucoepidermoid carcinoma, was given. Total conservative parotidectomy with selective neck dissection was performed. The resection specimen revealed features of SPA with loss of PTEN immunostaining in the ductal and acinar cells. SPA may mimic carcinomas like mucoepidermoid, salivary duct and acinic cell carcinoma on cytology, and may also be associated with an in\u00a0situ or invasive carcinoma. The diagnosis of SPA was not made on cytology in any of the eight prior cytology reports, and the possibility of malignancy was considered in three. Accurate cytologic diagnosis of SPA can obviate the need for neck dissection.<\/jats:p>","DOI":"10.1002\/dc.70209","type":"journal-article","created":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T11:20:45Z","timestamp":1788952845000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Sclerosing Polycystic Adenoma Masquerading as Malignancy on Fine Needle Aspiration Cytology"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9735-8882","authenticated-orcid":false,"given":"Priya","family":"Jayakumar","sequence":"first","affiliation":[{"name":"Department of Pathology All India Institute of Medical Sciences  New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-1237-0072","authenticated-orcid":false,"given":"Nivedhitha","family":"Murugesan","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology and Head\u2010Neck Surgery All India Institute of Medical Sciences  New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-7470-9846","authenticated-orcid":false,"given":"Sabari","family":"Sinehaa","sequence":"additional","affiliation":[{"name":"Department of Pathology All India Institute of Medical Sciences  New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9089-1721","authenticated-orcid":false,"given":"Archana","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Pathology All India Institute of Medical Sciences  New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6481-8093","authenticated-orcid":false,"given":"Chirom Amit","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology and Head\u2010Neck Surgery All India Institute of Medical Sciences  New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4303-1099","authenticated-orcid":false,"given":"Aanchal","family":"Kakkar","sequence":"additional","affiliation":[{"name":"Department of Pathology All India Institute of Medical Sciences  New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,9]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1007\/s12105-019-01088-0","article-title":"Sclerosing Polycystic \u201cAdenosis\u201d of Salivary Glands: A Neoplasm Characterized by PI3K Pathway Alterations More Correctly Named Sclerosing Polycystic Adenoma","volume":"14","author":"Bishop J. A.","year":"2020","journal-title":"Head and Neck Pathology"},{"key":"e_1_2_9_3_1","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1097\/PAS.0000000000001807","article-title":"Sclerosing Polycystic Adenoma of Salivary Glands: A Novel Neoplasm Characterized by PI3K\u2010AKT Pathway Alterations\u2010New Insights Into a Challenging Entity","volume":"46","author":"Sk\u00e1lov\u00e1 A.","year":"2022","journal-title":"American Journal of Surgical Pathology"},{"key":"e_1_2_9_4_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.anndiagpath.2022.151949","article-title":"Sclerosing Polycystic Adenoma\u2014A Review","volume":"59","author":"Petersson F.","year":"2022","journal-title":"Annals of Diagnostic Pathology"},{"key":"e_1_2_9_5_1","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1097\/00000478-200608000-00002","article-title":"Clonal Nature of Sclerosing Polycystic Adenosis of Salivary Glands Demonstrated by Using the Polymorphism of the Human Androgen Receptor (HUMARA) Locus as a Marker","volume":"30","author":"Skalova A.","year":"2006","journal-title":"American Journal of Surgical Pathology"},{"key":"e_1_2_9_6_1","doi-asserted-by":"crossref","first-page":"S27","DOI":"10.1038\/modpathol.2016.167","article-title":"Newly Described Salivary Gland Tumors","volume":"30","author":"Skalova A.","year":"2017","journal-title":"Modern Pathology"},{"key":"e_1_2_9_7_1","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1007\/s12105-022-01420-1","article-title":"Update From the 5th Edition of the World Health Organization Classification of Head and Neck Tumors: Salivary Glands","volume":"16","author":"Sk\u00e1lov\u00e1 A.","year":"2022","journal-title":"Head and Neck Pathology"},{"key":"e_1_2_9_8_1","first-page":"773","article-title":"Sclerosing Polycystic Adenoma: Conclusive Clinical and Molecular Evidence of Its Neoplastic Nature","volume":"34","author":"Hernandez\u2010Prera J.","year":"2021","journal-title":"Modern Pathology"},{"key":"e_1_2_9_9_1","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1159\/000326420","article-title":"Sclerosing Polycystic Adenosis of the Left Parotid Gland:Report of a Case With Fine Needle Aspiration Cytology","volume":"48","author":"Imamura Y.","year":"2004","journal-title":"Acta Cytologica"},{"key":"e_1_2_9_10_1","first-page":"189","article-title":"Sclerosing Polycystic Adenosis: A Case Report","volume":"2","author":"Kloppenborg R. P.","year":"2006","journal-title":"B\u2010ENT"},{"key":"e_1_2_9_11_1","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1097\/01.pas.0000186394.64840.1d","article-title":"Sclerosing Polycystic Adenosis of the Salivary Gland: A Report of 16 Cases","volume":"30","author":"Gnepp D. 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M.","year":"2021","journal-title":"Cancer Cytopathology"},{"key":"e_1_2_9_18_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.humpath.2025.105870","article-title":"BSND: An Emerging Immunohistochemical Marker That Reliably Distinguishes Benign From Malignant Oncocytic Salivary Gland Tumors","volume":"161","author":"Tandon A.","year":"2025","journal-title":"Human Pathology"}],"container-title":["Diagnostic Cytopathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/dc.70209","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/dc.70209","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/dc.70209","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T11:20:48Z","timestamp":1788952848000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/dc.70209"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,9]]},"references-count":17,"alternative-id":["10.1002\/dc.70209"],"URL":"https:\/\/doi.org\/10.1002\/dc.70209","archive":["Portico"],"relation":{},"ISSN":["8755-1039","1097-0339"],"issn-type":[{"value":"8755-1039","type":"print"},{"value":"1097-0339","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,9]]},"assertion":[{"value":"2026-07-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-20","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-09","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"dc.70209"}}