{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T12:07:27Z","timestamp":1788955647689,"version":"build-2803163510"},"reference-count":12,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T00:00:00Z","timestamp":1788912000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T00:00:00Z","timestamp":1788912000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diagnostic Cytopathology"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Epithelioid sarcoma (ES) is a rare, aggressive soft tissue malignancy with substantial morphologic overlap with other epithelioid neoplasms, creating diagnostic difficulty in cytology specimens. We report proximal\u2010type ES identified in cyst fluid from a lesion clinically interpreted as an epidermal inclusion cyst or abscess. A 43\u2010year\u2010old man presented with right thigh pain and a small cystic lesion on ultrasound. The fluid specimen was hypocellular and contained malignant epithelioid to rhabdoid cells with marked atypia, prominent nucleoli, and focal perinuclear clearing. Tumor cells expressed keratins and showed complete loss of INI1\/SMARCB1, while claudin\u20104, MOC31, desmin, and SOX10 were negative. A concurrent core biopsy confirmed proximal\u2010type ES. This case expands the recognized cytologic spectrum of proximal\u2010type ES and highlights that a hypocellular cyst fluid specimen may nevertheless provide diagnostically useful material when morphology is integrated with a focused immunohistochemical panel.<\/jats:p>","DOI":"10.1002\/dc.70210","type":"journal-article","created":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T11:24:36Z","timestamp":1788953076000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Epithelioid Enigma: Proximal\u2010Type Epithelioid Sarcoma in Cyst Fluid Cytology"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2716-4542","authenticated-orcid":false,"given":"Nathan","family":"McGrath","sequence":"first","affiliation":[{"name":"Department of Pathology University of Pittsburgh Medical Center  Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5321-190X","authenticated-orcid":false,"given":"Azfar","family":"Neyaz","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Pittsburgh Medical Center  Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5670-6254","authenticated-orcid":false,"given":"Samer","family":"Khader","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Pittsburgh Medical Center  Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,9]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAP.0000000000000102"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/dc.2018"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/dc.21818"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/dc.23294"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncy.22052"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/cyt.12528"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/dc.23494"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.5858\/135.2.268"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478\u2010200309000\u201000001"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAI.0000000000000097"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000000379"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/his.12460"}],"container-title":["Diagnostic Cytopathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/dc.70210","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/dc.70210","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/dc.70210","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T11:24:36Z","timestamp":1788953076000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/dc.70210"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,9]]},"references-count":12,"alternative-id":["10.1002\/dc.70210"],"URL":"https:\/\/doi.org\/10.1002\/dc.70210","archive":["Portico"],"relation":{},"ISSN":["8755-1039","1097-0339"],"issn-type":[{"value":"8755-1039","type":"print"},{"value":"1097-0339","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,9]]},"assertion":[{"value":"2026-08-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-04","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-09","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"dc.70210"}}