{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T08:52:00Z","timestamp":1791967920305,"version":"4.3.4"},"reference-count":8,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T00:00:00Z","timestamp":1791936000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T00:00:00Z","timestamp":1791936000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diagnostic Cytopathology"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Myeloid sarcoma is a rare extramedullary manifestation of acute myeloid leukemia, and primary involvement of the gastrointestinal tract and uterine cervix is particularly uncommon. Due to its low incidence and nonspecific clinical manifestations, the rates of clinical misdiagnosis and missed diagnosis remain high. Herein, we report two cases of myeloid sarcoma arising at rare sites. Case 1 was a 52\u2010year\u2010old male who presented with acute gastrointestinal obstruction. Intraoperative frozen section favored lymphoma, whereas touch imprint cytology of the tumor cut surface revealed numerous round to oval blasts with scant basophilic cytoplasm, finely granular nuclear chromatin, and small nucleoli, consistent with myeloid blast morphology and suggestive of myeloid sarcoma. Postoperative paraffin pathology confirmed the diagnosis of small intestinal myeloid sarcoma. Case 2 was a 63\u2010year\u2010old postmenopausal female who presented with unexplained vaginal discharge. Cervical liquid\u2010based cytology demonstrated scattered medium\u2010sized cells with finely dispersed nuclear chromatin and small nucleoli. Subsequent immunocytochemistry showed MPO and CD117 positivity, identifying myeloid blasts prior to tissue biopsy. Both cervical biopsy and bone marrow examination confirmed the diagnosis of cervical myeloid sarcoma. Cytological evaluation provided valuable morphological clues at different clinical stages, guided subsequent immunohistochemical workup, and shortened the diagnostic timeline in both cases. These cases demonstrate the cytomorphological features of MS at rare sites, and improving awareness of cytological manifestations of MS at atypical sites is helpful for early diagnosis and timely clinical intervention.<\/jats:p>","DOI":"10.1002\/dc.70218","type":"journal-article","created":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T08:26:09Z","timestamp":1791966369000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Two Cases of Myeloid Sarcoma at Rare Sites: Cytological Manifestations and Diagnostic Experience"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-4560-3924","authenticated-orcid":false,"given":"Jindu","family":"Wu","sequence":"first","affiliation":[{"name":"Department of Pathology Xiaogan Hospital Affiliated to Wuhan University of Science and Technology (Xiaogan Central Hospital)  Xiaogan Hubei China"},{"name":"Medical College Wuhan University of Science and Technology  Wuhan Hubei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-9978-0850","authenticated-orcid":false,"given":"Shuang","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Pathology Xiaogan Hospital Affiliated to Wuhan University of Science and Technology (Xiaogan Central Hospital)  Xiaogan Hubei China"},{"name":"Medical College Wuhan University of Science and Technology  Wuhan Hubei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-2250-4416","authenticated-orcid":false,"given":"Yin","family":"Liu","sequence":"additional","affiliation":[{"name":"Xiaonan District Maternal and Child Health Hospital  Xiaogan Hubei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-4739-0208","authenticated-orcid":false,"given":"Yan","family":"Chen","sequence":"additional","affiliation":[{"name":"Xiaonan District Maternal and Child Health Hospital  Xiaogan Hubei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-7499-1082","authenticated-orcid":false,"given":"Hanzhong","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Pathology Xiaogan Hospital Affiliated to Wuhan University of Science and Technology (Xiaogan Central Hospital)  Xiaogan Hubei China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,14]]},"reference":[{"issue":"1","key":"e_1_2_11_2_1","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1159\/000526635","article-title":"Myeloid Sarcoma: Features in Cytological Preparations and the Utility of Rapid On\u2010Site Evaluation (ROSE) in Triage","volume":"67","author":"Tariq H.","year":"2023","journal-title":"Acta Cytologica"},{"issue":"2","key":"e_1_2_11_3_1","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.jasc.2014.10.001","article-title":"Cytopathology of Myeloid Sarcoma: A Study of 16 Cases","volume":"4","author":"Singhal R. L.","year":"2015","journal-title":"Journal of the American Society of Cytopathology"},{"key":"e_1_2_11_4_1","doi-asserted-by":"crossref","first-page":"1262","DOI":"10.12659\/AJCR.911390","article-title":"A Case of Granulocytic Sarcoma or Extramedullary Acute Myelomonocytic Leukemia of the Gallbladder","volume":"19","author":"Holzwanger E. A.","year":"2018","journal-title":"American Journal of Case Reports"},{"issue":"6","key":"e_1_2_11_5_1","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.1038\/sj.leu.2402958","article-title":"Outcome in Patients With Nonleukemic Granulocytic Sarcoma Treated With Chemotherapy With or Without Radiotherapy","volume":"17","author":"Tsimberidou A. M.","year":"2003","journal-title":"Leukemia"},{"issue":"1","key":"e_1_2_11_6_1","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1186\/s12890-019-0975-7","article-title":"Primary Bronchial Myeloid Sarcoma Mimicking Bronchogenic Carcinoma: A Case Report","volume":"19","author":"Wang W.","year":"2019","journal-title":"BMC Pulmonary Medicine"},{"issue":"1","key":"e_1_2_11_7_1","doi-asserted-by":"crossref","first-page":"78","DOI":"10.31768\/2312-8852.2017.39(1):78-85","article-title":"Diagnostic Challenges With Intraoral Myeloid Sarcoma: Report of Two Cases and Review of World Literature","volume":"39","author":"Kumar P.","year":"2017","journal-title":"Experimental Oncology"},{"key":"e_1_2_11_8_1","doi-asserted-by":"crossref","first-page":"17","DOI":"10.4103\/1742-6413.117356","article-title":"Cytomorphology of Unusual Primary Tumors in the Pap Test","volume":"10","author":"Khalbuss W. E.","year":"2013","journal-title":"CytoJournal"},{"key":"e_1_2_11_9_1","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1002\/dc.23763","article-title":"Myeloid Sarcoma Identified on Liquid\u2010Based Cervical Cytology Samples: A Report of Two Cases","volume":"45","author":"Snider J.","year":"2017","journal-title":"Diagnostic Cytopathology"}],"container-title":["Diagnostic Cytopathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/dc.70218","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/dc.70218","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/dc.70218","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T08:26:10Z","timestamp":1791966370000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/dc.70218"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,14]]},"references-count":8,"alternative-id":["10.1002\/dc.70218"],"URL":"https:\/\/doi.org\/10.1002\/dc.70218","archive":["Portico"],"relation":{},"ISSN":["8755-1039","1097-0339"],"issn-type":[{"value":"8755-1039","type":"print"},{"value":"1097-0339","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,14]]},"assertion":[{"value":"2026-08-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-10-05","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-10-14","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"dc.70218"}}