{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T10:39:52Z","timestamp":1792492792187,"version":"4.5.0"},"reference-count":19,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T00:00:00Z","timestamp":1792454400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T00:00:00Z","timestamp":1792454400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diagnostic Cytopathology"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The International Academy of Cytology (IAC) recently introduced the Yokohama System (IAC\u2010YS) for reporting breast fine\u2010needle aspiration biopsy (FNAB) cytology. The Working Group on the Accuracy of Breast Fine\u2010Needle Aspiration Cytology of the Japanese Society of Clinical Cytology aimed to categorize breast FNAB specimens according to the IAC\u2010YS, assess the risk of malignancy (ROM) for each category, and evaluate the diagnostic yield of breast FNAB in Japan.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Breast FNAB specimens obtained between January 2010 and December 2019 from nine cooperating facilities were retrospectively reclassified following the IAC\u2010YS. The ROM for each category was calculated and compared with that using the conventional Japanese diagnostic system (CJS). Diagnostic yield was evaluated using a five\u2010category approach to distinguish benign from malignant samples.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In total, 1727 samples from 1722 patients were distributed as follows: Category 1 (insufficient material), 21.3%; Category 2 (benign), 38.9%; Category 3 (atypical), 6.9%; Category 4 (suspicious for malignancy), 10.0%; and Category 5 (malignant), 23.0%. Histological follow\u2010up was available for 856 cases (49.5%). The ROM was 13.1%, 4.8%, 26.9%, 84.3%, and 94.5% for Categories 1\u20135, respectively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>IAC\u2010YS showed a higher proportion of cases of Category 1 and a lower proportion of cases of Category 3 than the CJS. Despite these differences, both systems were equivalent in their impact on daily medical care, although ROM differed for the content of Categories 1 and 3. Quality assurance parameters for our data based on IAC\u2010YS are comparable to those of CJS.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/dc.70221","type":"journal-article","created":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T09:59:52Z","timestamp":1792490392000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Yokohama System for Breast Cytology in Japan: A Multicenter Comparison of the International Academy of Cytology Yokohama System and the Conventional Japanese System for Reporting Breast Fine\u2010Needle Aspiration Biopsy"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6343-2164","authenticated-orcid":false,"given":"Akiyoshi","family":"Hoshino","sequence":"first","affiliation":[{"name":"Department of Pathology Kitasato University Kitasato Institute Hospital  Minato Ward Tokyo Japan"},{"name":"Department of Pathology Kitasato University School of Medicine  Sagamihara Kanagawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4127-7287","authenticated-orcid":false,"given":"Ichiro","family":"Maeda","sequence":"additional","affiliation":[{"name":"Department of Pathology Kitasato University Kitasato Institute Hospital  Minato Ward Tokyo Japan"},{"name":"Department of Pathology Kitasato University School of Medicine  Sagamihara Kanagawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2388-290X","authenticated-orcid":false,"given":"Rieko","family":"Nishimura","sequence":"additional","affiliation":[{"name":"Department of Pathology Nagoya Medical Center  Nagoya Aichi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-4631-9304","authenticated-orcid":false,"given":"Eiji","family":"Abe","sequence":"additional","affiliation":[{"name":"Department of Pathology, Clinical Laboratory Kurume University Medical Center  Kurume Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1693-2852","authenticated-orcid":false,"given":"Yuji","family":"Kozuka","sequence":"additional","affiliation":[{"name":"Department of Pathology Mie University Hospital  Tsu Mie Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0361-8071","authenticated-orcid":false,"given":"Shinobu","family":"Masuda","sequence":"additional","affiliation":[{"name":"Division of Oncologic Pathology, Department of Pathology and Microbiology Nihon University School of Medicine  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-6383-8022","authenticated-orcid":false,"given":"Yasuyo","family":"Ohi","sequence":"additional","affiliation":[{"name":"Department of Pathology Sagara Hospital, Social Medical Corporation Hakuaikai  Kagoshima 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