{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T11:21:56Z","timestamp":1778844116139,"version":"3.51.4"},"reference-count":25,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2014,4,15]],"date-time":"2014-04-15T00:00:00Z","timestamp":1397520000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Drug Development Research"],"published-print":{"date-parts":[[2014,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:table-wrap position=\"anchor\">\n\n<jats:table frame=\"hsides\">\n<jats:col\/>\n<jats:tbody>\n<jats:tr>\n<jats:td>Preclinical Research<\/jats:td>\n<\/jats:tr>\n<\/jats:tbody>\n<\/jats:table>\n\n<\/jats:table-wrap><\/jats:p><jats:p>A series pf novel (7<jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>, 11<jats:styled-content style=\"fixed-case\">R<\/jats:styled-content>)\u2014substituted diphenyl\u20102,4,8,10\u2010tetraazaspiro [5.5] undecane\u20103\u2010thio\u20101,5,9\u2010triones 4<jats:styled-content style=\"fixed-case\">a\u2010j<\/jats:styled-content> and (7<jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>,11<jats:styled-content style=\"fixed-case\">R<\/jats:styled-content>)\u2010substituted diphenyl\u20102,4,8,10\u2010tetraazaspiro[5.5] undecane\u20103\u2010thio\u20101,5 dione, 9\u2010thiones 5<jats:styled-content style=\"fixed-case\">a\u2010j<\/jats:styled-content> were prepared using substituted aldehydes and urea\/thiourea in the presence of thiobarbituric acid under solvent free, thermal and microwave conditions catalyzed by ecofriendly <jats:styled-content style=\"fixed-case\">K<\/jats:styled-content>\u201010 clay. The antibacterial potency of these compounds in vitro on the gram negative strains <jats:styled-content style=\"fixed-case\"><jats:italic>E<\/jats:italic><\/jats:styled-content><jats:italic>scherichia coli<\/jats:italic> and <jats:styled-content style=\"fixed-case\"><jats:italic>P<\/jats:italic><\/jats:styled-content><jats:italic>seudomonas aeruginosa<\/jats:italic> and gram positive strains <jats:styled-content style=\"fixed-case\"><jats:italic>S<\/jats:italic><\/jats:styled-content><jats:italic>taphyllococcus aureus<\/jats:italic> and <jats:styled-content style=\"fixed-case\"><jats:italic>S<\/jats:italic><\/jats:styled-content><jats:italic>taphylococcus epidermidis<\/jats:italic> was evaluated.<\/jats:p>","DOI":"10.1002\/ddr.21172","type":"journal-article","created":{"date-parts":[[2014,4,15]],"date-time":"2014-04-15T13:14:57Z","timestamp":1397567697000},"page":"202-210","source":"Crossref","is-referenced-by-count":6,"title":["Synthesis of New Thiobarbituric Acid Derived Spiroheterobicyclic Compounds and Their Antimicrobial Activity"],"prefix":"10.1002","volume":"75","author":[{"given":"Gurpreet","family":"Kaur","sequence":"first","affiliation":[{"name":"Department of Applied Sciences PEC University of Technology  Chandigarh 160012 India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Parul","family":"Gupta","sequence":"additional","affiliation":[{"name":"Department of Microbiology Panjab University  Chandigarh 160014 India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kusum","family":"Harjai","sequence":"additional","affiliation":[{"name":"Department of Microbiology Panjab University  Chandigarh 160014 India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vasundhara","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Applied Sciences PEC University of Technology  Chandigarh 160012 India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,4,15]]},"reference":[{"key":"e_1_2_5_2_1","first-page":"933","article-title":"Studies on spiroheterocycles part\u20101: installation of biologically active heterocyclic nuclei into spiro compounds derived from cyclohexanone and diphenyl thiobarbituric acid","volume":"45","author":"Behera RK","year":"2006","journal-title":"Indian J Chem"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2005.06.004"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1021\/np070584j"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jfluchem.2012.06.032"},{"key":"e_1_2_5_6_1","unstructured":"FrankR ReichM JostockR BahrenbergG SchickH HenkelB SonnenscheinH.2008.Substituted spiro compounds and their use for producing pain relief medicaments. 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