{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T09:40:26Z","timestamp":1760348426969,"version":"build-2065373602"},"reference-count":7,"publisher":"Wiley","issue":"S1","license":[{"start":{"date-parts":[[2014,11,8]],"date-time":"2014-11-08T00:00:00Z","timestamp":1415404800000},"content-version":"vor","delay-in-days":7,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Drug Development Research"],"published-print":{"date-parts":[[2014,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:table-wrap position=\"anchor\">\n\n<jats:table frame=\"hsides\">\n<jats:col\/>\n<jats:col\/>\n<jats:tbody>\n<jats:tr>\n<jats:td>Clinical Development Phases I\u2010III Regulatory, Quality, Manufacturing<\/jats:td>\n<jats:td>Postmarketing Phase IV<\/jats:td>\n<\/jats:tr>\n<\/jats:tbody>\n<\/jats:table>\n\n<\/jats:table-wrap><\/jats:p><jats:p>Thalassemic trait (<jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>hal) is associated with rheumatic disease, particularly a mild form of seronegative polyarthritis resembling rheumatoid arthritis (<jats:styled-content style=\"fixed-case\">RA<\/jats:styled-content>), but not with other rheumatic diseases. The aim of this study was to estimate the frequency of Thal in patients with psoriatic arthritis (<jats:styled-content style=\"fixed-case\">PsA<\/jats:styled-content>) and to evaluate the efficacy of anti\u2010tumor necrosis factor alpha (<jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content>\u2010\u03b1) therapy in patients with <jats:styled-content style=\"fixed-case\">PsA<\/jats:styled-content> and Thal. We performed a retrospective study in 321 patients with <jats:styled-content style=\"fixed-case\">PsA<\/jats:styled-content> who started therapy with <jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content>\u2010\u03b1 blockers. For all patients included in the study, at baseline and every 3\u2009months for the 1\u2009year of follow up, data concerning <jats:styled-content style=\"fixed-case\">PsA<\/jats:styled-content> activity and ferritin levels were registered. In our group of <jats:styled-content style=\"fixed-case\">PsA<\/jats:styled-content> patients, a total of 27 (8%) with concomitant Thal were identified and included in the study. In patients without Thal, all variables improved significantly after 6\u2009months of therapy, while in patients with Thal, the same variables showed a significant decrease after 12\u2009months.: Our study shows that PsA is significantly associated with Thal, but further studies are needed to address this issue. The presence of Thal could be a negative predictor of achieving remission during treatment with <jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content>\u2010\u03b1\u2010blockers.<\/jats:p>","DOI":"10.1002\/ddr.21188","type":"journal-article","created":{"date-parts":[[2014,11,8]],"date-time":"2014-11-08T08:02:04Z","timestamp":1415433724000},"source":"Crossref","is-referenced-by-count":2,"title":["Thalassemic Trait Prevalence in Patients Affected by Psoriatic Arthritis in Anti\u2010<scp>TNF<\/scp> Treatment"],"prefix":"10.1002","volume":"75","author":[{"given":"Mariangela","family":"Atteno","sequence":"first","affiliation":[{"name":"Rheumatology Unit Department of Clinical Medicine and Surgery University Federico II  Naples Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luisa","family":"Costa","sequence":"additional","affiliation":[{"name":"Rheumatology Unit Department of Clinical Medicine and Surgery University Federico II  Naples Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Vitiello","sequence":"additional","affiliation":[{"name":"Rheumatology Unit Department of Clinical Medicine and Surgery University Federico II  Naples Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco","family":"Caso","sequence":"additional","affiliation":[{"name":"Rheumatology Unit Department of Medicine DIMED University of Padova  Padova Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanni","family":"Sarnelli","sequence":"additional","affiliation":[{"name":"Gastroenterology Unit Department of Clinical Medicine and Surgery University Federico II  Naples Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio","family":"Del Puente","sequence":"additional","affiliation":[{"name":"Rheumatology Unit Department of Clinical Medicine and Surgery University Federico II  Naples Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raffaele","family":"Scarpa","sequence":"additional","affiliation":[{"name":"Rheumatology Unit Department of Clinical Medicine and Surgery University Federico II  Naples Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,11,8]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"265","article-title":"Carrier screening for inherited hemoglobin disorders among secondary school students and young adults in Italy","volume":"5","author":"Amato A","year":"2014","journal-title":"J Community Genet"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(94)92585-2"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1568-9972(02)00143-X"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/739010"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1080\/088800102753356194"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/38.10.1021"},{"key":"e_1_2_6_8_1","first-page":"538","article-title":"Abnormal hemoglobins: detection and characterization","volume":"134","author":"Wajcman H","year":"2011","journal-title":"Indian J Med Res"}],"container-title":["Drug Development Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fddr.21188","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ddr.21188","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T08:59:14Z","timestamp":1760345954000},"score":1,"resource":{"primary":{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/10.1002\/ddr.21188"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,11]]},"references-count":7,"journal-issue":{"issue":"S1","published-print":{"date-parts":[[2014,11]]}},"alternative-id":["10.1002\/ddr.21188"],"URL":"https:\/\/doi.org\/10.1002\/ddr.21188","archive":["Portico"],"relation":{},"ISSN":["0272-4391","1098-2299"],"issn-type":[{"type":"print","value":"0272-4391"},{"type":"electronic","value":"1098-2299"}],"subject":[],"published":{"date-parts":[[2014,11]]}}}