{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T20:35:12Z","timestamp":1791318912935,"version":"4.3.1"},"reference-count":20,"publisher":"Wiley","issue":"S1","license":[{"start":{"date-parts":[[2014,11,8]],"date-time":"2014-11-08T00:00:00Z","timestamp":1415404800000},"content-version":"vor","delay-in-days":7,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Drug Development Research"],"published-print":{"date-parts":[[2014,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:table-wrap position=\"anchor\">\n\n<jats:table frame=\"hsides\">\n<jats:col\/>\n<jats:tbody>\n<jats:tr>\n<jats:td>Postmarketing Phase IV<\/jats:td>\n<\/jats:tr>\n<\/jats:tbody>\n<\/jats:table>\n\n<\/jats:table-wrap><\/jats:p><jats:p>Even if the existence of oral psoriasis has been suggested, it is still a debated issue. Indeed, oral inflammatory diseases may histologically resemble psoriasis\u2010related oral lesions. However, an increased prevalence of fissured tongue and geographic tongue has been associated with psoriatic patients, being a transitory and permanent lesion, respectively. Recently, it was hypothesized that gingivitis and periodontitis share the same underlying inflammatory pathogenetic process of psoriasis. Thus, in the present study, psoriatic patients were investigated for oral mucosa lesions prevalence as well as gum disease. Results displayed an increased association between gingivitis\/periodontitis and psoriasis, which may suggest common underlying pathogenic risk factors. However, large\u2010scale studies are needed to evaluate the real prevalence of gingivitis and periodontitis in these patients, to consider them a comorbidity of psoriasis.<\/jats:p>","DOI":"10.1002\/ddr.21194","type":"journal-article","created":{"date-parts":[[2014,11,8]],"date-time":"2014-11-08T08:02:04Z","timestamp":1415433724000},"source":"Crossref","is-referenced-by-count":19,"title":["Periodontal Disease: An Oral Manifestation of Psoriasis or an Occasional Finding?"],"prefix":"10.1002","volume":"75","author":[{"given":"Giulia","family":"Ganzetti","sequence":"first","affiliation":[{"name":"Clinic of Dermatology Polytechnic University of Marche Region  Ancona 60126 Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Campanati","sequence":"additional","affiliation":[{"name":"Clinic of Dermatology Polytechnic University of Marche Region  Ancona 60126 Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Santarelli","sequence":"additional","affiliation":[{"name":"Department of Clinical Specialistic and Stomatological Sciences Polytechnic University of Marche  Ancona 60126 Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentina","family":"Pozzi","sequence":"additional","affiliation":[{"name":"Department of Clinical Specialistic and Stomatological Sciences Polytechnic University of Marche  Ancona 60126 Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisa","family":"Molinelli","sequence":"additional","affiliation":[{"name":"Clinic of Dermatology Polytechnic University of Marche Region  Ancona 60126 Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilaria","family":"Minnetti","sequence":"additional","affiliation":[{"name":"Clinic of Dermatology Polytechnic University of Marche Region  Ancona 60126 Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valerio","family":"Brisigotti","sequence":"additional","affiliation":[{"name":"Clinic of Dermatology Polytechnic University of Marche Region  Ancona 60126 Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maurizio","family":"Procaccini","sequence":"additional","affiliation":[{"name":"Department of Clinical Specialistic and Stomatological Sciences Polytechnic University of Marche  Ancona 60126 Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monica","family":"Emanuelli","sequence":"additional","affiliation":[{"name":"Department of Clinical Specialistic and Stomatological Sciences Polytechnic University of Marche  Ancona 60126 Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annamaria","family":"Offidani","sequence":"additional","affiliation":[{"name":"Clinic of Dermatology Polytechnic University of Marche Region  Ancona 60126 Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,11,8]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2000.03765.x"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0733-8635(02)00065-7"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.2165\/1153424-S0-000000000-00000"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2012.10900.x"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1177\/1721727X1301100218"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-012-0678-9"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-013-0769-2"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-1373"},{"key":"e_1_2_7_10_1","first-page":"e371","article-title":"Oral lesions in 166 patients with cutaneous psoriasis: a controlled study","volume":"14","author":"Costa SC","year":"2009","journal-title":"Med Oral Patol Oral Cir Bucal"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-5945-4-16"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1517\/14712598.2013.848194"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.crohns.2012.05.023"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2010.10026.x"},{"key":"e_1_2_7_15_1","doi-asserted-by":"crossref","first-page":"307","DOI":"10.47102\/annals-acadmedsg.V33N3p307","article-title":"Salivary immunoglobulin A and lysozyme in patients with psoriasis","volume":"33","author":"Koh D","year":"2004","journal-title":"Ann Acad Med Singapore"},{"key":"e_1_2_7_16_1","first-page":"143","article-title":"The involvement of TGF\u2010\u03b21 and CTGF in regional gingival overgrowth","volume":"53","author":"Ni\u0163ulescu EA","year":"2012","journal-title":"Rom J Morphol Embryol"},{"issue":"5","key":"e_1_2_7_17_1","first-page":"s5","article-title":"Psoriasis and its comorbidities","volume":"11","author":"Onumah N","year":"2012","journal-title":"J Drugs Dermatol"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2011.10438.x"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2009.01408.x"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annder.2010.08.006"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.1995.tb01128.x"}],"container-title":["Drug Development Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fddr.21194","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ddr.21194","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T08:59:24Z","timestamp":1760345964000},"score":1,"resource":{"primary":{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/10.1002\/ddr.21194"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,11]]},"references-count":20,"journal-issue":{"issue":"S1","published-print":{"date-parts":[[2014,11]]}},"alternative-id":["10.1002\/ddr.21194"],"URL":"https:\/\/doi.org\/10.1002\/ddr.21194","archive":["Portico"],"relation":{},"ISSN":["0272-4391","1098-2299"],"issn-type":[{"value":"0272-4391","type":"print"},{"value":"1098-2299","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,11]]}}}